Pancuronium Bromide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328501

CAS#: 15500-66-0 (bromide)

Description: Pancuronium Bromide, also known as Pavulon and NA-97, is a bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release.


Price and Availability

Size
Price

10mg
USD 190
Size
Price

20mg
USD 350
Size
Price

50mg
USD 750

Pancuronium Bromide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 328501
Name: Pancuronium Bromide
CAS#: 15500-66-0 (bromide)
Chemical Formula: C35H60Br2N2O4
Exact Mass:
Molecular Weight: 732.683
Elemental Analysis: C, 57.38; H, 8.25; Br, 21.81; N, 3.82; O, 8.73


Related CAS #: 16974-53-1 (cation)   15500-66-0 (bromide)   22189-36-2 (bromide hydrate)    

Synonym: Pancuronium Bromide; NA-97; Org-NA-97; NA97; OrgNA97; NA 97; Org NA 97; Pavulon

IUPAC/Chemical Name: 1,1'-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3,17-diacetoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-2,16-diyl)bis(1-methylpiperidin-1-ium) bromide

InChi Key: NPIJXCQZLFKBMV-YTGGZNJNSA-L

InChi Code: InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

SMILES Code: C[C@@]12[C@@H](OC(C)=O)[C@@H]([N+]3(C)CCCCC3)C[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H]([N+]6(C)CCCCC6)C[C@]5(C)[C@@]4([H])CC2.[Br-].[Br-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Grong K, Salminen PR, Stangeland L, Dahle GO. Haemodynamic differences between pancuronium and vecuronium in an experimental pig model. Vet Anaesth Analg. 2015 May;42(3):242-9. doi: 10.1111/vaa.12198. Epub 2014 Jul 2. PubMed PMID: 24985148.

2: Zayed SI. Flow injection potentiometric determination of pancuronium bromide in pharmaceutical preparation and urine samples using modified carbon paste electrodes. Chem Pharm Bull (Tokyo). 2011;59(2):254-9. PubMed PMID: 21297308.

3: Petrů K, Jáč P, Lužová V, Kuneš J, Polášek M. Determination of muscle relaxants pancuronium and vecuronium bromide by capillary electrophoresis with capacitively coupled contactless conductivity detection. Electrophoresis. 2011 Apr;32(8):890-5. doi: 10.1002/elps.201000456. Epub 2011 Mar 10. PubMed PMID: 21394728.

4: Murthy V, D'Costa W, Nicolaides K, Davenport M, Fox G, Milner AD, Campbell M, Greenough A. Neuromuscular blockade and lung function during resuscitation of infants with congenital diaphragmatic hernia. Neonatology. 2013;103(2):112-7. doi: 10.1159/000342332. Epub 2012 Nov 24. PubMed PMID: 23182955.

5: Arita-Morioka K, Yamanaka K, Mizunoe Y, Ogura T, Sugimoto S. Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK. Antimicrob Agents Chemother. 2015 Jan;59(1):633-41. doi: 10.1128/AAC.04465-14. Epub 2014 Nov 17. PubMed PMID: 25403660; PubMed Central PMCID: PMC4291377.

6: Ogboli-Nwasor E. Medication errors in anaesthetic practice: a report of two cases and review of the literature. Afr Health Sci. 2013 Sep;13(3):845-9. doi: 10.4314/ahs.v13i3.46. Review. PubMed PMID: 24250330; PubMed Central PMCID: PMC3824420.

7: Stankov-Jovanovic VP, Nikolic-Mandic SD, Mandic LjM, Mitic VD. A modification of the kinetic determination of pancuronium bromide based on its inhibitory effect on cholinesterase. J Clin Lab Anal. 2007;21(2):124-31. PubMed PMID: 17385680.

8: Diaz LL, Zhang J, Heerdt PM. Comparative pharmacodynamics of pancuronium, cisatracurium, and CW002 in rabbits. J Am Assoc Lab Anim Sci. 2014 May;53(3):283-9. PubMed PMID: 24827571; PubMed Central PMCID: PMC4128567.

9: Miyazaki Y, Sunaga H, Hobo S, Miyano K, Uezono S. Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors. J Anesth. 2016 Aug;30(4):671-6. doi: 10.1007/s00540-016-2178-1. Epub 2016 May 4. PubMed PMID: 27146658.

10: Carvalho VH, Braga Ade F, Braga FS, Potério GM, Santos FN, Junqueira FE. Association between levobupivacaine and pancuronium. Interference in neuromuscular transmission and blockade in rats. Acta Cir Bras. 2016 Jul;31(7):486-9. doi: 10.1590/S0102-865020160070000009. PubMed PMID: 27487284.