Galocitabine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326903

CAS#: 124012-42-6

Description: Galocitabine, also known as Neofrutulon; RO-091390; RO-09-1390, is a thymidylate synthase inhibitor potentially for the treatment of cancer.


Price and Availability

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Galocitabine is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 326903
Name: Galocitabine
CAS#: 124012-42-6
Chemical Formula: C19H22FN3O8
Exact Mass: 439.139
Molecular Weight: 439.3964
Elemental Analysis: C, 51.94; H, 5.05; F, 4.32; N, 9.56; O, 29.13


Synonym: Neofrutulon; RO-091390; RO 091390; RO091390; RO-09-1390; Galocitabine

IUPAC/Chemical Name: N-(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-3,4,5-trimethoxybenzamide

InChi Key: TVYPSLDUBVTDIS-FUOMVGGVSA-N

InChi Code: InChI=1S/C19H22FN3O8/c1-8-13(24)14(25)18(31-8)23-7-10(20)16(22-19(23)27)21-17(26)9-5-11(28-2)15(30-4)12(6-9)29-3/h5-8,13-14,18,24-25H,1-4H3,(H,21,22,26,27)/t8-,13-,14-,18-/m1/s1

SMILES Code: O=C(NC(C(F)=CN1[C@H]2[C@@H]([C@@H]([C@@H](C)O2)O)O)=NC1=O)C3=CC(OC)=C(OC)C(OC)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shindoh H, Kawashima A, Shishido N, Nakano K, Kobayashi K, Horii I.
Relationship between AUC of 5'-DFUR and toxicity of capecitabine,
fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats. J
Toxicol Sci. 2006 Aug;31(3):265-85. PubMed PMID: 16960436.

2: Funaki T, Onodera H, Ogawa K, Ichihara S, Fukazawa H, Kuruma I. Simultaneous
determination of a new anticancer drug galocitabine and its metabolites in blood
by high-performance liquid chromatography. J Pharm Biomed Anal. 1993
Apr-May;11(4-5):379-84. PubMed PMID: 8357875.