CAS#21668-77-9 | 36589-58-9

Eprodisate Sodium
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326900

CAS#: 36589-58-9 (Sodium)

Description: Eprodisate, also known as 3-PDS; NC-503; 3PDS, is an orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis.

Chemical Structure

Eprodisate Sodium

CAS# 36589-58-9 (Sodium)

Instruction

Theoretical Analysis

MedKoo Cat#: 326900
Name: Eprodisate Sodium
CAS#: 36589-58-9 (Sodium)
Chemical Formula: C3H6Na2O6S2
Exact Mass: 0.00
Molecular Weight: 248.175
Elemental Analysis: C, 14.52; H, 2.44; Na, 18.53; O, 38.68; S, 25.84

Price and Availability

Size	Price	Availability
1g	USD 150	2 weeks
2g	USD 250	2 weeks
5g	USD 450	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 21668-77-9 (free base) 36589-58-9 (Sodium) 36589-58-9 (Disodium)

Synonym: 3-PDS; NC-503; 3PDS; Eprodisate Sodium; Kiacta.

IUPAC/Chemical Name: 1,3-Propanedisulfonic acid, disodium salt

InChi Key: DKGJFKPIUSHDIT-UHFFFAOYSA-L

InChi Code: InChI=1S/C3H8O6S2.2Na/c4-10(5,6)2-1-3-11(7,8)9;;/h1-3H2,(H,4,5,6)(H,7,8,9);;/q;2*+1/p-2

SMILES Code: O=S(CCCS(=O)([O-])=O)([O-])=O.[Na+].[Na+]

Appearance: Solid powder

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 21668-77-9(Eprodisate) 36589-58-9(Eprodisate Sodium)

Instruction:

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Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Real de Asúa D, Costa R, Galván JM, Filigheddu MT, Trujillo D, Cadiñanos J. Systemic AA amyloidosis: epidemiology, diagnosis, and management. Clin Epidemiol. 2014 Oct 29;6:369-77. doi: 10.2147/CLEP.S39981. eCollection 2014. Review. PubMed PMID: 25378951; PubMed Central PMCID: PMC4218891.

2: Wang P, Ding K. Proteoglycans and glycosaminoglycans in misfolded proteins formation in Alzheimer's disease. Protein Pept Lett. 2014;21(10):1048-56. Review. PubMed PMID: 24975673.

3: Rumjon A, Coats T, Javaid MM. Review of eprodisate for the treatment of renal disease in AA amyloidosis. Int J Nephrol Renovasc Dis. 2012;5:37-43. doi: 10.2147/IJNRD.S19165. Epub 2012 Feb 24. PubMed PMID: 22427728; PubMed Central PMCID: PMC3304340.

4: Martínez-Valle F, Gironella-Mesa M, Solans-Laqué R. [New trends in the treatment of amyloidosis]. Med Clin (Barc). 2012 May 26;138(15):667-72. doi: 10.1016/j.medcli.2011.09.032. Epub 2011 Dec 22. Review. Spanish. PubMed PMID: 22197598.

5: Herrera GA, Teng J, Turbat-Herrera EA. Renal amyloidosis: current views on pathogenesis and impact on diagnosis. Contrib Nephrol. 2011;169:232-46. doi: 10.1159/000314795. Epub 2011 Jan 20. PubMed PMID: 21252523.

6: Zdrojewski Z. [Amyloidosis in rheumatic diseases]. Ann Acad Med Stetin. 2010;56 Suppl 1:7-15. Review. Polish. PubMed PMID: 21365934.

7: Blank N, Lorenz HM. [Diagnostics and therapy of AA amyloidosis]. Pathologe. 2009 May;30(3):219-25. doi: 10.1007/s00292-009-1140-5. Review. German. PubMed PMID: 19333604.

8: Manenti L, Tansinda P, Vaglio A. Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother. 2008 Aug;9(12):2175-80. doi: 10.1517/14656566.9.12.2175 . Review. PubMed PMID: 18671471.

9: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Apr;30(3):231-51. PubMed PMID: 18597009.

10: Pani A. [A new treatment of renal disease in AA amyloidosis...and not only that?]. G Ital Nefrol. 2008 Jan-Feb;25(1):12. Italian. PubMed PMID: 18264913.

11: Rule AD, Leung N. Eprodisate slows the progression of renal disease in patients with AA amyloidosis. Nat Clin Pract Nephrol. 2007 Nov;3(11):592-3. Epub 2007 Sep 18. PubMed PMID: 17876351.

12: Manenti L, Tansinda P, Vaglio A. Eprodisate in AA amyloidosis. N Engl J Med. 2007 Sep 13;357(11):1153; author reply 1153-4. PubMed PMID: 17855678.

13: Hazenberg BP, Bijzet J, Limburg PC, Skinner M, Hawkins PN, Butrimiene I, Livneh A, Lesnyak O, Nasonov EL, Filipowicz-Sosnowska A, Gül A, Merlini G, Wiland P, Ozdogan H, Gorevic PD, Maïz HB, Benson MD, Direskeneli H, Kaarela K, Garceau D, Hauck W, Van Rijswijk MH. Diagnostic performance of amyloid A protein quantification in fat tissue of patients with clinical AA amyloidosis. Amyloid. 2007 Jun;14(2):133-40. Erratum in: Amyloid. 2007 Dec;14(4):325. PubMed PMID: 17577686.

14: Rajkumar SV, Gertz MA. Advances in the treatment of amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2413-5. PubMed PMID: 17554124.

15: Dember LM, Hawkins PN, Hazenberg BP, Gorevic PD, Merlini G, Butrimiene I, Livneh A, Lesnyak O, Puéchal X, Lachmann HJ, Obici L, Balshaw R, Garceau D, Hauck W, Skinner M; Eprodisate for AA Amyloidosis Trial Group. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2349-60. PubMed PMID: 17554116.

16: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):231-45. PubMed PMID: 17520107.

17: Grateau G, Valleix S, Callard P. [Multisystemic amyloidosis in 2007]. Rev Med Interne. 2007 May;28(5):281-3. Epub 2007 Jan 26. Review. French. PubMed PMID: 17291633.

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