Fluparoxan HCl

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MedKoo CAT#: 326883

CAS#: 105226-30-0 (HCl)

Description: Fluparoxan, also known as GR-50360; GR-50360A, is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold). It was shown to possess central α2-adrenoceptor antagonist activity after oral doses in man and was patented as an antidepressant by Glaxo in the early 1980s, but its development was discontinued when the compound failed to show a clear clinical advantage over existing therapies.


Chemical Structure

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Fluparoxan HCl
CAS# 105226-30-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 326883
Name: Fluparoxan HCl
CAS#: 105226-30-0 (HCl)
Chemical Formula: C10H11ClFNO2
Exact Mass: 0.00
Molecular Weight: 231.651
Elemental Analysis: C, 51.85; H, 4.79; Cl, 15.30; F, 8.20; N, 6.05; O, 13.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GR-50360; GR50360; GR 50360; GR-50360A; Fluparoxan hydrochloride

IUPAC/Chemical Name: (3aS,9aS)-5-fluoro-2,3,3a,9a-tetrahydro-1H-benzo[5,6][1,4]dioxino[2,3-c]pyrrole hydrochloride

InChi Key: JNYKORXHNIRXSA-OZZZDHQUSA-N

InChi Code: InChI=1S/C10H10FNO2.ClH/c11-6-2-1-3-7-10(6)14-9-5-12-4-8(9)13-7;/h1-3,8-9,12H,4-5H2;1H/t8-,9-;/m0./s1

SMILES Code: FC1=C2O[C@]3([H])[C@](OC2=CC=C1)([H])CNC3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 105182-47-6 ((3aR, 9aR)-Fluparoxan) 105226-30-0 ((3aR, 9aR)-Fluparoxan hydrochloride)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 231.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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