Beloxepin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326881

CAS#: 135928-30-2

Description: Beloxepin, also known as ADL-6906; ORG-4428, is an oral dual selective serotonin and norepinephrine uptake inhibitor.


Price and Availability

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Beloxepin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 326881
Name: Beloxepin
CAS#: 135928-30-2
Chemical Formula: C19H21NO2
Exact Mass: 295.1572
Molecular Weight: 295.382
Elemental Analysis: C, 77.26; H, 7.17; N, 4.74; O, 10.83


Synonym: ADL-6906; ADL 6906; ADL6906; ORG-4428; ORG4428; ORG 4428; Beloxepin.

IUPAC/Chemical Name: cis-1,3,4,13b-Tetrahydro-2,10-dimethyldibenz(2,3:6,7)oxepino(4,5-c)pyridin-4a(2H)-ol

InChi Key: RPMDQAYGQBREBS-VQIMIIECSA-N

InChi Code: InChI=1S/C19H21NO2/c1-13-6-5-7-14-16-12-20(2)11-10-19(16,21)15-8-3-4-9-17(15)22-18(13)14/h3-9,16,21H,10-12H2,1-2H3/t16-,19-/m1/s1

SMILES Code: O[C@]12[C@](C3=CC=CC(C)=C3OC4=CC=CC=C42)([H])CN(C)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Fujimaki K, Morinobu S, Duman RS. Administration of a cAMP phosphodiesterase 4
inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus.
Neuropsychopharmacology. 2000 Jan;22(1):42-51. PubMed PMID: 10633490.

2: van Bemmel AL, Vermeeren MT, Ruigt G, Sennef C. The acute effects of the
noradrenaline reuptake inhibitor Org 4428 on EEG sleep in healthy volunteers.
Neuropsychobiology. 1999;40(2):107-14. PubMed PMID: 10474065.

3: Paanakker JE, de Jong J, Thio JM, van Hal HJ. Validation of an LC-MS assay for
the quantification of the enantiomers of Org 4428 in human plasma. J Pharm Biomed
Anal. 1998 Feb;16(6):981-9. PubMed PMID: 9547701.

4: Inoue T, Hashimoto S, Tsuchiya K, Izumi T, Ohmori T, Koyama T. Effect of
citalopram, a selective serotonin reuptake inhibitor, on the acquisition of
conditioned freezing. Eur J Pharmacol. 1996 Sep 5;311(1):1-6. PubMed PMID:
8884229.