Palonidipine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328110

CAS#: 96515-73-0 (free base)

Description: Palonidipine is a calcium channel antagonist potentially for the treatment of angina pectoris and hypertension.


Price and Availability

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Palonidipine is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 328110
Name: Palonidipine
CAS#: 96515-73-0 (free base)
Chemical Formula: C29H34FN3O6
Exact Mass: 539.2432
Molecular Weight: 539.6044
Elemental Analysis: C, 64.55; H, 6.35; F, 3.52; N, 7.79; O, 17.79


Related CAS #: 96515-73-0 (free base)   96515-74-1 (HCl)    

Synonym: Palonidipine; Palonidipine hydrochloride; TC-81; TC81; TC 81

IUPAC/Chemical Name: 3-(3-(benzyl(methyl)amino)-2,2-dimethylpropyl) 5-methyl 4-(2-fluoro-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: MUNSLZPCNUVWCH-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H34FN3O6/c1-18-24(27(34)38-6)26(22-14-21(33(36)37)12-13-23(22)30)25(19(2)31-18)28(35)39-17-29(3,4)16-32(5)15-20-10-8-7-9-11-20/h7-14,26,31H,15-17H2,1-6H3

SMILES Code: O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC([N+]([O-])=O)=CC=C2F)OCC(C)(C)CN(C)CC3=CC=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kishimoto T, Okamiya Y, Aoki K, Ota M, Hoshina K, Takeshita T. [Effect of palonidipine hydrochloride (TC-81), a new dihydropyridine derivative, on various myocardial ischemic models]. Nihon Yakurigaku Zasshi. 1993 Aug;102(2):85-100. Japanese. PubMed PMID: 8370558.

2: Okamiya Y, Kishimoto T, Aoki K, Sunakawa K, Hoshina K, Takeshita T. [Effect of palonidipine hydrochloride (TC-81), a novel calcium antagonist, on the canine coronary artery]. Nihon Yakurigaku Zasshi. 1993 Jul;102(1):23-33. Japanese. PubMed PMID: 8335285.

3: Aoki K, Kishimoto T, Sunakawa K, Okamiya Y, Hoshina K, Takeshita T. [Inhibitory effects of palonidipine hydrochloride (TC-81) on contractions induced by various vasoconstrictors in rat aorta]. Nihon Yakurigaku Zasshi. 1993 Apr;101(4):281-8. Japanese. PubMed PMID: 8514210.