Remetinostat

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 327021

CAS#: 946150-57-8

Description: Remetinostat, also known as SHP-141, is a topical formulation containing the histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Upon cutaneous administration, SHP-141 selectively binds to and inhibits HDAC, resulting in an accumulation of highly acetylated histones in the skin (dermis and epidermis), the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. These events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. Topical administration of SHP-141 allows for high concentrations of this agent locally while minimizing systemic toxicity.

Chemical Structure

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Remetinostat
CAS# 946150-57-8
Instruction

Theoretical Analysis

MedKoo Cat#: 327021
Name: Remetinostat
CAS#: 946150-57-8
Chemical Formula: C16H21NO6
Exact Mass: 323.14
Molecular Weight: 323.345
Elemental Analysis: C, 59.43; H, 6.55; N, 4.33; O, 29.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Remetinostat; SHP-141; SHP-141; SHP-141; SHAPE

IUPAC/Chemical Name: methyl 4-((8-(hydroxyamino)-8-oxooctanoyl)oxy)benzoate

InChi Key: XDZAHHULFQIBFE-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H21NO6/c1-22-16(20)12-8-10-13(11-9-12)23-15(19)7-5-3-2-4-6-14(18)17-21/h8-11,21H,2-7H2,1H3,(H,17,18)

SMILES Code: O=C(OC)C1=CC=C(OC(CCCCCCC(NO)=O)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 323.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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