PZM21
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MedKoo CAT#: 526831

CAS#: 1997387-43-5

Description: PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective μ-opioid receptor agonist which produces μ-opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less β-arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent than morphine or TRV130 as an analgesic, but also had significantly reduced adverse effects, with less constipation than morphine, and very little respiratory depression, even at high doses.


Price and Availability

Size
Price

10mg
USD 190
100mg
USD 950
1g
USD 3450
Size
Price

25mg
USD 350
200mg
USD 1650
2g
USD 5250
Size
Price

50mg
USD 550
500mg
USD 2250
5g
USD 8250

PZM21, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526831
Name: PZM21
CAS#: 1997387-43-5
Chemical Formula: C19H27N3O2S
Exact Mass: 361.1824
Molecular Weight: 361.504
Elemental Analysis: C, 63.13; H, 7.53; N, 11.62; O, 8.85; S, 8.87


Synonym: PZM21; PZM-21; PZM 21.

IUPAC/Chemical Name: 1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea

InChi Key: MEDBIJOVZJEMBI-YOEHRIQHSA-N

InChi Code: InChI=1S/C19H27N3O2S/c1-14(10-16-8-9-25-13-16)21-19(24)20-12-17(22(2)3)11-15-4-6-18(23)7-5-15/h4-9,13-14,17,23H,10-12H2,1-3H3,(H2,20,21,24)/t14-,17-/m0/s1

SMILES Code: O=C(N[C@@H](C)CC1=CSC=C1)NC[C@@H](N(C)C)CC2=CC=C(O)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling
RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan,
Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. Structure-based
discovery of opioid analgesics with reduced side effects. Nature. 2016 Sep
8;537(7619):185-190. doi: 10.1038/nature19112. PubMed PMID: 27533032; PubMed
Central PMCID: PMC5161585.

2: Link A, Müller CE. G-Protein-Coupled Receptors: Sustained Signaling via
Intracellular Megaplexes and Pathway-Specific Drugs. Angew Chem Int Ed Engl. 2016
Dec 23;55(52):15962-15964. doi: 10.1002/anie.201609015. PubMed PMID: 27775210.

3: Kostic M. Biasing Opioid Receptors and Cholesterol as a Player in
Developmental Biology. Cell Chem Biol. 2016 Sep 22;23(9):1039-40. doi:
10.1016/j.chembiol.2016.09.007. PubMed PMID: 27662248.