LY 235959
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525525

CAS#: 137433-06-8

Description: LY 235959 is a competitive NMDA receptor antagonist.

Chemical Structure

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LY 235959
CAS# 137433-06-8
Instruction

Theoretical Analysis

MedKoo Cat#: 525525
Name: LY 235959
CAS#: 137433-06-8
Chemical Formula: C11H20NO5P
Exact Mass: 277.11
Molecular Weight: 277.260
Elemental Analysis: C, 47.65; H, 7.27; N, 5.05; O, 28.85; P, 11.17

Price and Availability

Size Price Availability Quantity
10mg USD 310
50mg USD 920
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Synonym: LY 235959; LY235959; LY-235959.

IUPAC/Chemical Name: 3-Isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3S-(3alpha,4aalpha,6beta,8aalpha))-

InChi Key: STIRHCNEGQQBOY-QEYWKRMJSA-N

InChi Code: InChI=1S/C11H20NO5P/c13-11(14)10-4-9-3-7(6-18(15,16)17)1-2-8(9)5-12-10/h7-10,12H,1-6H2,(H,13,14)(H2,15,16,17)/t7-,8-,9+,10-/m0/s1

SMILES Code: O=C([C@H]1NC[C@]2([H])CC[C@H](CP(O)(O)=O)C[C@]2([H])C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 277.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rawls SM, Gomez T, Raffa RB. An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2). Pharmacol Biochem Behav. 2007 Mar;86(3):499-504. Epub 2007 Jan 20. PubMed PMID: 17306870.

2: Gasior M, Borowicz K, Kleinrok Z, Starownik R, Czuczwar SJ. Anticonvulsant and adverse effects of MK-801, LY 235959, and GYKI 52466 in combination with Ca2+ channel inhibitors in mice. Pharmacol Biochem Behav. 1997 Apr;56(4):629-35. PubMed PMID: 9130287.

3: Bhargava HN. Enhancement of morphine actions in morphine-naive and morphine-tolerant mice by LY 235959, a competitive antagonist of the NMDA receptor. Gen Pharmacol. 1997 Jan;28(1):61-4. PubMed PMID: 9112078.

4: Borowicz KK, Gasior M, Kleinrok Z, Czuczwar SJ. Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Epilepsia. 1996 Jul;37(7):618-24. PubMed PMID: 8681893.