Val-cit-PAB-OH (ADC peptide linker)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 620108

CAS#: 159857-79-1

Description: Val-cit-PAB-OH is an precursor for making MC-​Val-​Cit-​PAB, which is also known as MC-​Val-​Cit-​PAB-OH. Val-cit-PAB-OH is a cathepsin cleavable ADC peptide linker. MC-​Val-​Cit-​PAB is useful for making ADC conjugate (antibody-drug conjugate). FDA approved drugs such as brentuximab vedotin used this linker. **** Please also see similar products: #610235: MC-Val-Cit-PAB (ADC peptide linker) and #610234: MC-Val-Cit-PAB-PNP (ADC peptide linker); #620108 Val-cit-PAB-OH (ADC peptide linker).


Price and Availability

Size
Price

1g
USD 3250
10g
USD 9850
Size
Price

2g
USD 4350
20g
Ask price
Size
Price

5g
USD 7950

Val-cit-PAB-OH, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 620108
Name: Val-cit-PAB-OH (ADC peptide linker)
CAS#: 159857-79-1
Chemical Formula: C18H29N5O4
Exact Mass: 379.222
Molecular Weight: 379.461
Elemental Analysis: C, 56.98; H, 7.70; N, 18.46; O, 16.86


Related CAS #: 159857-79-1 (Val-cit-PAB-OH)   159857-80-4 (MC-Val-Cit-PAB)   159857-81-5 (MC-Val-Cit-PAB-PNP)    

Synonym: Val-cit-PAB-OH

IUPAC/Chemical Name: (S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide

InChi Key: VEGGTWZUZGZKHY-GJZGRUSLSA-N

InChi Code: InChI=1S/C18H29N5O4/c1-11(2)15(19)17(26)23-14(4-3-9-21-18(20)27)16(25)22-13-7-5-12(10-24)6-8-13/h5-8,11,14-15,24H,3-4,9-10,19H2,1-2H3,(H,22,25)(H,23,26)(H3,20,21,27)/t14-,15-/m0/s1

SMILES Code: NC(NCCC[C@H](NC([C@@H](N)C(C)C)=O)C(NC1=CC=C(CO)C=C1)=O)=O


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Please also see similar products:
#610235: MC-Val-Cit-PAB (ADC peptide linker)
#610234: MC-Val-Cit-PAB-PNP (ADC peptide linker); #
#620108 Val-cit-PAB-OH (ADC peptide linker).


References

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