BI605906
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526805

CAS#: 960293-88-3

Description: BI605906 is a IKKβ inhibitor. BI605906 inhibits TNFα-dependent IκB degradation and expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2.


Chemical Structure

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BI605906
CAS# 960293-88-3

Theoretical Analysis

MedKoo Cat#: 526805
Name: BI605906
CAS#: 960293-88-3
Chemical Formula: C17H22F2N4O3S2
Exact Mass: 432.11
Molecular Weight: 432.505
Elemental Analysis: C, 47.21; H, 5.13; F, 8.79; N, 12.95; O, 11.10; S, 14.83

Price and Availability

Size Price Availability Quantity
5mg USD 385 2 weeks
10mg USD 685 2 weeks
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Synonym: BI605906; BI-605906; BI 605906.

IUPAC/Chemical Name: 3-Amino-4-(1,1-difluoropropyl)-6-(4-methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxamide

InChi Key: IYHHRZBKXXKDDY-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H22F2N4O3S2/c1-3-17(18,19)10-8-11(23-6-4-9(5-7-23)28(2,25)26)22-16-12(10)13(20)14(27-16)15(21)24/h8-9H,3-7,20H2,1-2H3,(H2,21,24)

SMILES Code: O=C(C1=C(N)C2=C(C(F)(F)CC)C=C(N3CCC(S(=O)(C)=O)CC3)N=C2S1)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 432.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cameron AR, Morrison V, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD,
Balfour DJ, Savinko T, Wong AK, Viollet B, Sakamoto K, Fagerholm SC, Foretz M,
Lang CC, Rena G. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes
Status. Circ Res. 2016 Jul 14. pii: CIRCRESAHA.116.308445. [Epub ahead of print]
PubMed PMID: 27418629.


2: Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver
EG, Cohen P. Novel cross-talk within the IKK family controls innate immunity.
Biochem J. 2011 Feb 15;434(1):93-104. doi: 10.1042/BJ20101701. PubMed PMID:
21138416.