PD 132002

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525840

CAS#: 134452-04-3

Description: PD 132002 is a renin inhibitor. Studies with PD 132002 show that the dissociation sometimes observed in studies with renin inhibitors between changes in BP (blood pressure) and PRA (plasma renin activity) may be attributed to the assay used to determine PRA.

Chemical Structure

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PD 132002
CAS# 134452-04-3
Instruction

Theoretical Analysis

MedKoo Cat#: 525840
Name: PD 132002
CAS#: 134452-04-3
Chemical Formula: C31H50N4O9S
Exact Mass: 654.33
Molecular Weight: 654.815
Elemental Analysis: C, 56.86; H, 7.70; N, 8.56; O, 21.99; S, 4.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PD-132002; PD132002; PD 132002

IUPAC/Chemical Name: (2R)-methyl 3-amino-2-((2S)-N-((2S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl)-2-(morpholine-4-sulfonamido)-3-phenylpropanamido)-3-oxopropanoate

InChi Key: DUBBEKGYCZQJMR-QSKQZBQPSA-N

InChi Code: InChI=1S/C31H50N4O9S/c1-21(2)18-26(36)28(37)25(20-23-12-8-5-9-13-23)35(27(29(32)38)31(40)43-3)30(39)24(19-22-10-6-4-7-11-22)33-45(41,42)34-14-16-44-17-15-34/h4,6-7,10-11,21,23-28,33,36-37H,5,8-9,12-20H2,1-3H3,(H2,32,38)/t24-,25-,26-,27+,28?/m0/s1

SMILES Code: O=C(N)[C@H](C(OC)=O)N(C([C@H](CC1=CC=CC=C1)NS(=O)(N2CCOCC2)=O)=O)[C@@H](CC3CCCCC3)C(O)[C@@H](O)CC(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 654.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Palmer RK, Rapundalo ST, Batley BL, Barnes AE, Singh S, Ryan MJ, Taylor DG Jr. Disparity between blood pressure and PRA inhibition after administration of a renin inhibitor to anesthetized dogs: methodological considerations. Clin Exp Hypertens. 1993 Jul;15(4):663-81. PubMed PMID: 8374609.
2: Repine JT, Himmelsbach RJ, Hodges JC, Kaltenbronn JS, Sircar I, Skeean RW, Brennan ST, Hurley TR, Lunney E, Humblet CC, et al. Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate. J Med Chem. 1991 Jul;34(7):1935-43. PubMed PMID: 2066966.