PD 122860

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MedKoo CAT#: 525831

CAS#: 122576-86-7

Description: PD 122860 is a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wave. PD 122860 selectively relaxed potassium-contracted aortic rings and inhibited [3H]nitrendipine binding to rat brain membranes, suggesting that the vasodilator activity of PD 122860 is due to Ca++ channel blockade.

Chemical Structure

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PD 122860
CAS# 122576-86-7
Instruction

Theoretical Analysis

MedKoo Cat#: 525831
Name: PD 122860
CAS#: 122576-86-7
Chemical Formula: C23H20F3N3O4S
Exact Mass: 491.11
Molecular Weight: 491.483
Elemental Analysis: C, 56.21; H, 4.10; F, 11.60; N, 8.55; O, 13.02; S, 6.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PD122860; PD-122860; PD 122860

IUPAC/Chemical Name: ethyl 5-cyano-6-methyl-2-((pyridin-4-ylsulfonyl)methyl)-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate

InChi Key: ZUAWKQNJMCYABQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20F3N3O4S/c1-3-33-22(30)21-19(13-34(31,32)15-8-10-28-11-9-15)29-14(2)17(12-27)20(21)16-6-4-5-7-18(16)23(24,25)26/h4-11,20,29H,3,13H2,1-2H3

SMILES Code: O=C(C1=C(CS(=O)(C2=CC=NC=C2)=O)NC(C)=C(C#N)C1C3=CC=CC=C3C(F)(F)F)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 491.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Haleen SJ, Steffen RP, Sircar I, Major TC, Taylor MD, Pugsley TA, Weishaar RE.
PD 122860: a novel dihydropyridine with sodium channel stimulating and calcium
channel blocking properties. J Pharmacol Exp Ther. 1989 Jul;250(1):22-30. PubMed
PMID: 2473188.