PD 117588

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525824

CAS#: 99734-97-1

Description: PD 117588 is a new quinolone against bacterial isolates from cancer patients. PD 117558 was found to have a broad antimicrobial spectrum with excellent activity against all Gram-positive isolates (including methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus faecalis and Group JK-corynebacteria). It was also extremely active against Gram-negative bacilli with the exception of Pseudomonas aeruginosa against which ciprofloxacin was more active. PD 117558 also had lower minimal inhibitory concentrations for most organisms tested than either imipenem or ceftazidime.

Chemical Structure

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PD 117588
CAS# 99734-97-1
Instruction

Theoretical Analysis

MedKoo Cat#: 525824
Name: PD 117588
CAS#: 99734-97-1
Chemical Formula: C20H23F2N3O3
Exact Mass: 391.17
Molecular Weight: 391.412
Elemental Analysis: C, 61.37; H, 5.92; F, 9.71; N, 10.74; O, 12.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PD-117588; PD117588; PD 117588

IUPAC/Chemical Name: 1-cyclopropyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

InChi Key: WDBGUJBLPRXPIX-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23F2N3O3/c1-2-23-8-11-5-6-24(9-11)18-15(21)7-13-17(16(18)22)25(12-3-4-12)10-14(19(13)26)20(27)28/h7,10-12,23H,2-6,8-9H2,1H3,(H,27,28)

SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(CNCC)CC4)=C3F)C1=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 391.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rolston KV, LeBlanc B, Gooch G, Ho DH, Bodey GP. In-vitro activity of PD
117558, a new quinolone against bacterial isolates from cancer patients. J
Antimicrob Chemother. 1989 Mar;23(3):363-71. PubMed PMID: 2732120.