Levoprotiline hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525440

CAS#: 76496-69-0

Description: Levoprotiline hydrochloride is a new antidepressant.

Chemical Structure

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Levoprotiline hydrochloride
CAS# 76496-69-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 525440
Name: Levoprotiline hydrochloride
CAS#: 76496-69-0
Chemical Formula: C20H24ClNO
Exact Mass: 0.00
Molecular Weight: 329.868
Elemental Analysis: C, 72.82; H, 7.33; Cl, 10.75; N, 4.25; O, 4.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Levoprotiline hydrochloride; Levoprotiline HCl; CGP 12103 A; CGP-12 103 A.

IUPAC/Chemical Name: 9,10-Ethanoanthracene-9(10H)-ethanol, alpha-((methylamino)methyl)-, hydrochloride, (R)-

InChi Key: MUOSVLIKDZRWMP-DQBGKMJDSA-N

InChi Code: InChI=1S/C20H23NO.ClH/c1-21-13-14(22)12-20-11-10-15(16-6-2-4-8-18(16)20)17-7-3-5-9-19(17)20;/h2-9,14-15,21-22H,10-13H2,1H3;1H/t14-,15?,20?;/m1./s1

SMILES Code: O[C@@H](CNC)CC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Levoprotiline hydrochloride is a new antidepressant.
In vitro activity: TBD
In vivo activity: The effects of repeated administration of levoprotiline, a novel type of tetracyclic antidepressant on histamine H1, muscarinic acetylcholine and alpha 1-adrenergic receptors and the response of phosphoinositide hydrolysis (PI) stimulated by histamine in the cortex of the rat brain were investigated. This demonstrates that the repeated treatment with levoprotiline has prominent action on the regulation of histamine H1 receptors and PI response coupling to histamine H1 receptors in vivo. Reference: Jpn J Pharmacol. 1992 May;59(1):31-5. https://pubmed.ncbi.nlm.nih.gov/1324374/

Preparing Stock Solutions

The following data is based on the product molecular weight 329.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Noguchi S, Inukai T. Repeated treatment with levoprotiline, a novel antidepressant, up-regulates histamine H1 receptors and phosphoinositide hydrolysis response in vivo. Jpn J Pharmacol. 1992 May;59(1):31-5. doi: 10.1254/jjp.59.31. PMID: 1324374.
In vitro protocol: TBD
In vivo protocol: 1. Noguchi S, Inukai T. Repeated treatment with levoprotiline, a novel antidepressant, up-regulates histamine H1 receptors and phosphoinositide hydrolysis response in vivo. Jpn J Pharmacol. 1992 May;59(1):31-5. doi: 10.1254/jjp.59.31. PMID: 1324374.

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1: Noguchi S, Okada M, Inukai T. Pharmacological profile of the new antidepressant levoprotiline. Arzneimittelforschung. 1992 Jun;42(6):787-94. PubMed PMID: 1418032.