JNJ-39933673

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525401

CAS#: 1003005-29-5 (free)

Description: JNJ-39933673, also known as TA-1887, is a SGLT inhibitor. TA-1887 antagonizes diabetic cachexia and decreases mortality. TA-1887 treatment prevented pancreatic beta cell death, enhanced preservation of beta cell mass and endogenous insulin secretion, and increased insulin sensitivity. Moreover, TA-1887 treatment attenuated inflammation, oxidative stress, and cellular senescence, especially in visceral white adipose tissue, and antagonized endothelial dysfunction.

Chemical Structure

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JNJ-39933673
CAS# 1003005-29-5 (free)
Instruction

Theoretical Analysis

MedKoo Cat#: 525401
Name: JNJ-39933673
CAS#: 1003005-29-5 (free)
Chemical Formula: C24H26FNO5
Exact Mass: 427.18
Molecular Weight: 427.470
Elemental Analysis: C, 67.43; H, 6.13; F, 4.44; N, 3.28; O, 18.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1003005-29-5 (free)   1404307-42-1(hemihydrate)    

Synonym: JNJ-39933673; JNJ39933673; JNJ 39933673; JNJ-39933673 hemihydrate; TA 1887; TA-1887.

IUPAC/Chemical Name: (2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluoro-1H-indol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

InChi Key: PXRGAWZIQZMHTH-PFKOEMKTSA-N

InChi Code: InChI=1S/C24H26FNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/m1/s1

SMILES Code: O[C@H]1[C@H](N2C=C(CC3=CC=C(C4CC4)C=C3)C5=C2C=CC=C5F)O[C@H](CO)[C@@H](O)[C@@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 427.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shimada K, Kanasaki K, Kato M, Ogura Y, Takagaki Y, Monno I, Hirai T, Kitada M, Koya D. Adenosine/adenosine type 1 receptor signaling pathway did not play dominant roles on the influence of sodium-glucose cotransporter 2 inhibitor in the kidney of bovine serum albumin-overloaded streptozotocin-induced diabetic mice. J Diabetes Investig. 2022 Jun;13(6):955-964. doi: 10.1111/jdi.13760. Epub 2022 Mar 9. PMID: 35098679; PMCID: PMC9153834.


2: Li L, Konishi Y, Morikawa T, Zhang Y, Kitabayashi C, Kobara H, Masaki T, Nakano D, Hitomi H, Kobori H, Nishiyama A. Effect of a SGLT2 inhibitor on the systemic and intrarenal renin-angiotensin system in subtotally nephrectomized rats. J Pharmacol Sci. 2018 Jun;137(2):220-223. doi: 10.1016/j.jphs.2017.10.006. Epub 2017 Oct 28. PMID: 29983235; PMCID: PMC6050139.


3: Sugizaki T, Zhu S, Guo G, Matsumoto A, Zhao J, Endo M, Horiguchi H, Morinaga J, Tian Z, Kadomatsu T, Miyata K, Itoh H, Oike Y. Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality. NPJ Aging Mech Dis. 2017 Sep 8;3:12. doi: 10.1038/s41514-017-0012-0. PMID: 28900540; PMCID: PMC5591191.


4: Oguma T, Kuriyama C, Nakayama K, Matsushita Y, Hikida K, Tsuda-Tsukimoto M, Saito A, Arakawa K, Ueta K, Minami M, Shiotani M. Changes in glucose-induced plasma active glucagon-like peptide-1 levels by co-administration of sodium- glucose cotransporter inhibitors with dipeptidyl peptidase-4 inhibitors in rodents. J Pharmacol Sci. 2016 Dec;132(4):255-261. doi: 10.1016/j.jphs.2016.10.006. Epub 2016 Oct 28. PMID: 27889414.


5: Nomura S, Yamamoto Y, Matsumura Y, Ohba K, Sakamaki S, Kimata H, Nakayama K, Kuriyama C, Matsushita Y, Ueta K, Tsuda-Tsukimoto M. Novel Indole-N-glucoside, TA-1887 As a Sodium Glucose Cotransporter 2 Inhibitor for Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 Nov 13;5(1):51-5. doi: 10.1021/ml400339b. PMID: 24900773; PMCID: PMC4027614.