Indolapril hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525285

CAS#: 80828-32-6 (HCl)

Description: Indolapril hydrochloride is a novel nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor. The antihypertensive response to Indolapril hydrochloride (0.03-1.0 mg/kg p.o.) was found to correlate with inhibition of vascular tissue ACE.


Chemical Structure

img
Indolapril hydrochloride
CAS# 80828-32-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 525285
Name: Indolapril hydrochloride
CAS#: 80828-32-6 (HCl)
Chemical Formula: C24H35ClN2O5
Exact Mass: 0.00
Molecular Weight: 467.000
Elemental Analysis: C, 61.73; H, 7.55; Cl, 7.59; N, 6.00; O, 17.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 80828-32-6 (HCl)   80828-34-8 (diacid)   80876-01-3 (free base)  

Synonym: Indolapril hydrochloride; Indolapril HCl; CI 907; CI907; CI-907; REV 6000A(SS); Sch 31846 hydrochloride.

IUPAC/Chemical Name: (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, monohydrochloride

InChi Key: QNSWMJYOGMUVGO-PABIKWFMSA-N

InChi Code: InChI=1S/C24H34N2O5.ClH/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29;/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29);1H/t16-,18-,19-,20-,21-;/m0./s1

SMILES Code: O=C([C@H]1N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)[C@@]3([H])CCCC[C@@]3([H])C1)O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 467.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Blankley CJ, Kaltenbronn JS, DeJohn DE, Werner A, Bennett LR, Bobowski G, Krolls U, Johnson DR, Pearlman WM, Hoefle ML, et al. Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids. J Med Chem. 1987 Jun;30(6):992-8. PubMed PMID: 3035180.

2: La Rocca PT, Squibb RE, Powell ML, Szot RJ, Black HE, Schwartz E. Acute and subchronic toxicity of a nonsulfhydryl angiotensin-converting enzyme inhibitor. Toxicol Appl Pharmacol. 1986 Jan;82(1):104-11. PubMed PMID: 3003964.

3: Roark WH, Tinney FJ, Cohen D, Essenburg AD, Kaplan HR. Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme. J Med Chem. 1985 Sep;28(9):1291-5. PubMed PMID: 2993618.

4: Brunner HR, Nussberger J, Waeber B. The present molecules of converting enzyme inhibitors. J Cardiovasc Pharmacol. 1985;7 Suppl 1:S2-11. Review. PubMed PMID: 2580170.

5: Ryan MJ, Boucher DM, Cohen DM, Olszewski BJ, Singer RM, Smith RD, Kaplan HR. Antihypertensive profile of the angiotensin-converting enzyme inhibitors CI-906 and CI-907. Fed Proc. 1984 Apr;43(5):1330-2. PubMed PMID: 6323224.

6: Kaplan HR, Cohen DM, Essenburg AD, Major TC, Mertz TE, Ryan MJ. CI-906 and CI-907: new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors. Fed Proc. 1984 Apr;43(5):1326-9. PubMed PMID: 6323223.

7: Ryan MJ, Boucher DM, Cohen DM, Essenburg AD, Major TC, Mertz TE, Olszewski BJ, Randolph AE, Singer RM, Kaplan HR. Antihypertensive effects of CI-907 (indolapril): a novel nonsulfhydryl angiotensin converting enzyme inhibitor. J Pharmacol Exp Ther. 1984 Feb;228(2):312-8. PubMed PMID: 6319675.

8: Baum T, Sybertz EJ, Watkins RW, Ahn HS, Nelson S, Eynon E, Vander Vliet G, Pula KK, Sabin C, Desiderio DM, Becker FT, Vemulapalli S. Antihypertensive activity of SCH 31846, a non-sulfhydryl angiotensin-converting enzyme inhibitor. J Cardiovasc Pharmacol. 1983 Jul-Aug;5(4):655-67. PubMed PMID: 6193365.

9: Sybertz EJ, Baum T, Ahn HS, Nelson S, Eynon E, Desiderio DM, Pula K, Becker F, Sabin C, Moran R, Vander Vliet G, Kastner B, Smith E. Angiotensin-converting enzyme inhibitory activity of SCH 31846, a new non-sulfhydryl inhibitor. J Cardiovasc Pharmacol. 1983 Jul-Aug;5(4):643-54. PubMed PMID: 6193364.