JNJ-20788560

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525313

CAS#: 825649-28-3

Description: JNJ-20788560 is a delta opioid agonist analgesics, exhibited high DOR affinity, with K(i) values of 1.7 and 2.0nM, respectively. It is selective for DOR over the mu opioid receptor (MOPr or MOR), with 596- and 122-fold selectivity, respectively.


Price and Availability

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JNJ-20788560 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525313
Name: JNJ-20788560
CAS#: 825649-28-3
Chemical Formula: C25H28N2O2
Exact Mass: 388.21508
Molecular Weight: 388.5
Elemental Analysis: C, 77.29; H, 7.26; N, 7.21; O, 8.24


Synonym: JNJ-20788560; JNJ 20788560; JNJ20788560.

IUPAC/Chemical Name: 9-(8-Azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide

InChi Key: MISSUZBVOCUXTG-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28N2O2/c1-3-27(4-2)25(28)16-9-12-21-23(15-16)29-22-8-6-5-7-20(22)24(21)17-13-18-10-11-19(14-17)26-18/h5-9,12,15,18-19,26H,3-4,10-11,13-14H2,1-2H3

SMILES Code: O=C(C1=CC(OC2=C/3C=CC=C2)=C(C=C1)C3=C4CC(N5)CCC5C/4)N(CC)CC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Codd EE, Ma J, Zhang SP, Stone DJ Jr, Colburn RW, Brandt MR, Chevalier KM, Zhu Y, Peng S, Cai C, Acton PD, Flores CM. Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range. Pharmacol Biochem Behav. 2010 Aug;96(2):130-5. doi: 10.1016/j.pbb.2010.04.020. Epub 2010 May 12. PubMed PMID: 20438745.

2: Codd EE, Carson JR, Colburn RW, Stone DJ, Van Besien CR, Zhang SP, Wade PR, Gallantine EL, Meert TF, Molino L, Pullan S, Razler CM, Dax SL, Flores CM. JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. J Pharmacol Exp Ther. 2009 Apr;329(1):241-51. doi: 10.1124/jpet.108.146969. Epub 2009 Jan 16. PubMed PMID: 19151246.