JNJ-19567470

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525312

CAS#: 724471-26-5

Description: JNJ-19567470 is a selective, non-peptide CRF receptor 1 antagonist. It is a novel target for developing anti-panic drugs that are as effective as benzodiazepines in acute treatment of a panic attack which prevents sodium lactate-induced acute panic-like responses.


Price and Availability

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JNJ-19567470 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525312
Name: JNJ-19567470
CAS#: 724471-26-5
Chemical Formula: C22H27BrN4O
Exact Mass: 442.13682
Molecular Weight: 443.38
Elemental Analysis: C, 59.60; H, 6.14; Br, 18.02; N, 12.64; O, 3.61


Synonym: JNJ-19567470; JNJ 19567470; JNJ19567470.

IUPAC/Chemical Name: 4-Piperidinemethanol, 1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-

InChi Key: GGRHUOGLCCJDDN-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H27BrN4O/c1-13-9-18(23)10-14(2)20(13)27-11-15(3)19-21(24-16(4)25-22(19)27)26-7-5-17(12-28)6-8-26/h9-11,17,28H,5-8,12H2,1-4H3

SMILES Code: OCC1CCN(C2=C3C(N(C4=C(C)C=C(Br)C=C4C)C=C3C)=NC(C)=N2)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shekhar A, Johnson PL, Fitz SD, Nakazato A, Chaki S, Steckler T, Schmidt M. A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactate-induced acute panic-like responses. Int J Neuropsychopharmacol. 2011 Apr;14(3):355-65. doi: 10.1017/S1461145710001355. Epub 2010 Nov 19. PubMed PMID: 21087553.