JNJ-10329670

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525302

CAS#: 400797-24-2

Description: JNJ-10329670 represents a novel class of immunosuppressive compounds. JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S. The properties of JNJ 10329670 make it a candidate for immunosuppressive therapy of allergies and autoimmune diseases.


Price and Availability

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JNJ-10329670 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525302
Name: JNJ-10329670
CAS#: 400797-24-2
Chemical Formula: C30H34ClF3N6O3S
Exact Mass: 650.20537
Molecular Weight: 651.14
Elemental Analysis: C, 55.34; H, 5.26; Cl, 5.44; F, 8.75; N, 12.91; O, 7.37; S, 4.92


Synonym: JNJ-10329670; JNJ 10329670; JNJ10329670.

IUPAC/Chemical Name: 1H-Pyrazolo(4,3-C)pyridine, 1-(3-(4-(6-chloro-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)propyl)-4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-

InChi Key: NVAHQQYCEWEDKM-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H34ClF3N6O3S/c1-36-26-9-8-22(31)18-27(26)40(29(36)41)23-10-15-37(16-11-23)13-3-14-39-25-12-17-38(44(2,42)43)19-24(25)28(35-39)20-4-6-21(7-5-20)30(32,33)34/h4-9,18,23H,3,10-17,19H2,1-2H3

SMILES Code: FC(C1=CC=C(C2=NN(CCCN3CCC(N4C5=CC(Cl)=CC=C5N(C)C4=O)CC3)C6=C2CN(S(=O)(C)=O)CC6)C=C1)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Grice CA, Tays K, Khatuya H, Gustin DJ, Butler CR, Wei J, Sehon CA, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2209-12. Epub 2006 Feb 3. PubMed PMID: 16458510.

2: Gustin DJ, Sehon CA, Wei J, Cai H, Meduna SP, Khatuya H, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1687-91. PubMed PMID: 15745822.

3: Thurmond RL, Sun S, Sehon CA, Baker SM, Cai H, Gu Y, Jiang W, Riley JP, Williams KN, Edwards JP, Karlsson L. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76. Epub 2003 Oct 17. PubMed PMID: 14566006.