JNJ-10229570

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525298

CAS#: 524923-88-4

Description: JNJ-10229570 is a novel MC1R and MC5R antagonist was used to treat primary human sebaceous cells. It might have a potential for the treatment of acne and other sebaceous gland pathologies.


Price and Availability

Size
Price

Size
Price

Size
Price

JNJ-10229570 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 525298
Name: JNJ-10229570
CAS#: 524923-88-4
Chemical Formula: C22H19N3O2S
Exact Mass: 389.1198
Molecular Weight: 389.47
Elemental Analysis: C, 67.84; H, 4.92; N, 10.79; O, 8.22; S, 8.23


Synonym: JNJ-10229570; JNJ10229570; JNJ 10229570; UNII-N9IX402L35.

IUPAC/Chemical Name: Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-

InChi Key: XTHRTBCPBWJYRO-GHVJWSGMSA-N

InChi Code: InChI=1S/C22H19N3O2S/c1-26-19-14-8-6-12-17(19)21-24-22(23-16-10-4-3-5-11-16)28-25(21)18-13-7-9-15-20(18)27-2/h3-15H,1-2H3/b23-22+

SMILES Code: COC1=CC=CC=C1C2=N/C(SN2C3=CC=CC=C3OC)=N\C4=CC=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Eisinger M, Li WH, Anthonavage M, Pappas A, Zhang L, Rossetti D, Huang Q, Seiberg M. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32. doi: 10.1016/j.jdermsci.2011.04.001. Epub 2011 Apr 15. PubMed PMID: 21602033.