Izonsteride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525295

CAS#: 176975-26-1

Description: Izonsteride, also known as LY320236, is a selective and potent inhibitor of the 5α-reductase, with dual effects on both the type I and type II isoforms of the enzyme. Izonsteride can be used in the treatment of benign prostatic hyperplasia. Izonsteride may also be useful in the treatment of androgenic alopecia.


Chemical Structure

img
Izonsteride
CAS# 176975-26-1

Theoretical Analysis

MedKoo Cat#: 525295
Name: Izonsteride
CAS#: 176975-26-1
Chemical Formula: C24H26N2OS2
Exact Mass: 422.15
Molecular Weight: 422.610
Elemental Analysis: C, 68.21; H, 6.20; N, 6.63; O, 3.79; S, 15.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Izonsteride; LY-320236; LY320236; LY 320236;

IUPAC/Chemical Name: Bezo(f)quinolin-3(2H)-one, 8-((4-ethyl-2-benzothiazolyl)thio)-1,4,4a,5,6,10b-hexahydro-4,10b-dimethyl-,(4aR-trans)

InChi Key: VMGWGDPZHXPFTC-HYBUGGRVSA-N

InChi Code: InChI=1S/C24H26N2OS2/c1-4-15-6-5-7-19-22(15)25-23(29-19)28-17-9-10-18-16(14-17)8-11-20-24(18,2)13-12-21(27)26(20)3/h5-7,9-10,14,20H,4,8,11-13H2,1-3H3/t20-,24-/m1/s1

SMILES Code: c1c(cc2CC[C@@H]3[C@@](c2c1)(CCC(N3C)=O)C)Sc1nc2c(s1)cccc2CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 422.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Eisenberger MA, Laufer M, Vogelzang NJ, Sartor O, Thornton D, Neubauer BL, Sinibaldi V, Lieskovsky G, Carducci MA, Zahurak M, Raghavan D. Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible mechanism of action. Urology. 2004 Jan;63(1):114-9. PubMed PMID: 14751361.

2: Trump DL, Waldstreicher JA, Kolvenbag G, Wissel PS, Neubauer BL. Androgen antagonists: Potential role in prostate cancer prevention. Urology. 2001 Apr;57(4 Suppl 1):64-7. PubMed PMID: 11295597.

3: McNulty AM, Audia JE, Bemis KG, Goode RL, Rocco VP, Neubauer BL. Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5alpha-reductase. J Steroid Biochem Mol Biol. 2000 Jan-Feb;72(1-2):13-21. PubMed PMID: 10731633.