Faropenem medoxomil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326766

CAS#: 141702-36-5 (medoxomil); 106559-89-1 (Faropenem)

Description: Faropenem medoxomil, also known as Faropenem daloxate or Faropenem medoxil, is an orally active beta-lactam antibiotic belonging to the penem group. It is resistant to some forms of extended-spectrum beta-lactamase. Faropenem medoxomil is a prodrug of Faropenem.


Price and Availability

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Faropenem medoxomil is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 326766
Name: Faropenem medoxomil
CAS#: 141702-36-5 (medoxomil); 106559-89-1 (Faropenem)
Chemical Formula: C17H19NO8S
Exact Mass: 397.0831
Molecular Weight: 397.398
Elemental Analysis: C, 51.38; H, 4.82; N, 3.52; O, 32.21; S, 8.07


Synonym: A0026; A-0026; A 0026; Faropenem medoxomil; Faropenem daloxate; Faropenem medoxil.

IUPAC/Chemical Name: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R,6S)-6-((R)-1-hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

InChi Key: JQBKWZPHJOEQAO-DVPVEWDBSA-N

InChi Code: InChI=1S/C17H19NO8S/c1-7(19)11-14(20)18-12(13(27-15(11)18)9-4-3-5-23-9)16(21)24-6-10-8(2)25-17(22)26-10/h7,9,11,15,19H,3-6H2,1-2H3/t7-,9-,11+,15-/m1/s1

SMILES Code: O=C(C(N12)=C([C@@H]3OCCC3)S[C@]2([H])[C@@H]([C@H](O)C)C1=O)OCC4=C(C)OC(O4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Faqi AS, Lanphear C, Gill S, Colagiovanni DB. Juvenile toxicity study of faropenem medoxomil in beagle puppies. Reprod Toxicol. 2010 Dec;30(4):619-24. doi: 10.1016/j.reprotox.2010.07.010. Epub 2010 Aug 11. PubMed PMID: 20708074.

2: Faropenem medoxomil: A0026, BAY 56-6854, BAY 566854, faropenem daloxate, SUN 208, SUN A0026. Drugs R D. 2008;9(2):115-24. Review. PubMed PMID: 18298129.

3: Gettig JP, Crank CW, Philbrick AH. Faropenem medoxomil. Ann Pharmacother. 2008 Jan;42(1):80-90. Epub 2007 Dec 19. Review. PubMed PMID: 18094341.

4: Hadley JA, Tillotson GS, Tosiello R, Echols RM. Faropenem medoxomil: a treatment option in acute bacterial rhinosinusitis. Expert Rev Anti Infect Ther. 2006 Dec;4(6):923-37. Review. PubMed PMID: 17181408.

5: Upchurch J, Rosemore M, Tosiello R, Kowalsky S, Echols R. Randomized double-blind study comparing 7- and 10-day regimens of faropenem medoxomil with a 10-day cefuroxime axetil regimen for treatment of acute bacterial sinusitis. Otolaryngol Head Neck Surg. 2006 Oct;135(4):511-7. PubMed PMID: 17011409.