Ocaphane Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525773

CAS#: 2185-98-0

Description: Ocaphane Hydrochloride is a strong antitumor agent used on a number of animal tumors such as Brown-Pearce carcinoma. In clinical trials, it was found to be effective in treating patients with malignant pleural effusion and cancer of the head and neck. However, it was fairly toxic to hemopoietic organs.


Price and Availability

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Ocaphane Hydrochloride is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525773
Name: Ocaphane Hydrochloride
CAS#: 2185-98-0
Chemical Formula: C14H21Cl3N2O2
Exact Mass: 354.0669
Molecular Weight: 355.6877
Elemental Analysis: C, 47.27; H, 5.95; Cl, 29.90; N, 7.88; O, 9.00


Synonym: AT581; AT 581; AT-581; Ocaphane HCl

IUPAC/Chemical Name: (S)-2-amino-3-(2-((bis(2-chloroethyl)amino)methyl)phenyl)propanoic acid hydrochloride

InChi Key: ZGUNYXYRAMFTFG-ZOWNYOTGSA-N

InChi Code: InChI=1S/C14H20Cl2N2O2.ClH/c15-5-7-18(8-6-16)10-12-4-2-1-3-11(12)9-13(17)14(19)20;/h1-4,13H,5-10,17H2,(H,19,20);1H/t13-;/m0./s1

SMILES Code: N[C@@H](CC1=CC=CC=C1CN(CCCl)CCCl)C(O)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Su-yin C, Hsiu-fang Y, Pin H. Absorption, distribution and excretion of C14-AT-581 in animals. Chin Med J (Engl). 1976 Nov;2(6):441-4. PubMed PMID: 828876.
2: Yang JL, Lu FL, Wang LJ, Xu B. [The therapeutic effect of O-[bis-(2-chloroethyl)-aminomethyl]-phenylalanine dihydrochloride (ocaphane, AT-581) on intracerebral growth of Brown-Pearce carcinoma in rabbits (author's transl)]. Yao Xue Xue Bao. 1981 Dec;16(12):881-5. Chinese. PubMed PMID: 7340381.
3: Yang JL, Hsu B. [Studies on the combined chemotherapy of o-[bis-(2-chloroethyl)-aminomethyl]-phenylalanine dihydrochloride (AT-581) and operation in the treatment of Brown-Pearce carcinoma in the rabbit]. Yao Xue Xue Bao. 1966 Feb;13(2):113-8. Chinese. PubMed PMID: 5952402.
4: YANG JL, HSU B. [THERAPEUTIC EFFECT OF AT-581 ON THE BROWN-PEARCE CARCINOMA IN RABBITS AND ITS INFLUENCE ON MITOSIS OF THE TUMOR CELLS]. Yao Xue Xue Bao. 1965 Apr;12:235-41. Chinese. PubMed PMID: 14321745.