ICI 211965

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525264

CAS#: 129424-08-4

Description: ICI 211965 is a selective and orally potent 5-lipoxygenase inhibitor. ICI 211965 may be useful in regulating production of those interleukins involved in joint cartilage destruction.


Price and Availability

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Price

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ICI 211965 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525264
Name: ICI 211965
CAS#: 129424-08-4
Chemical Formula: C24H23NO2S
Exact Mass: 389.14495
Molecular Weight: 389.51
Elemental Analysis: C, 74.00; H, 5.95; N, 3.60; O, 8.22; S, 8.23


Synonym: ICI 211965; ICI-211965; ICI211965;

IUPAC/Chemical Name: 1-(3-(Naphth-2-ylmethoxy)phenyl)-1-(thiazol-2-yl)propyl methyl ether

InChi Key: XYRDHZXSQUWVCD-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H23NO2S/c1-3-24(26-2,23-25-13-14-28-23)21-9-6-10-22(16-21)27-17-18-11-12-19-7-4-5-8-20(19)15-18/h4-16H,3,17H2,1-2H3

SMILES Code: COC(C1=NC=CS1)(C2=CC=CC(OCC3=CC=C4C=CC=CC4=C3)=C2)CC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Crawley GC, Dowell RI, Edwards PN, Foster SJ, McMillan RM, Walker ER, Waterson D, Bird TG, Bruneau P, Giroaeau JM. Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. J Med Chem. 1992 Jul 10;35(14):2600-9. PubMed PMID: 1321908.

2: Rainsford KD, Ying C, Smith F. Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors. J Pharm Pharmacol. 1996 Jan;48(1):46-52. PubMed PMID: 8722494.