ICI 198615

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525263

CAS#: 104448-53-5

Description: ICI 198615 is a novel, potent and selective peptide leukotriene antagonist. ICI 198,615 may be useful for the the treatment of allergic diseases.


Price and Availability

Size
Price

Size
Price

Size
Price

ICI 198615 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 525263
Name: ICI 198615
CAS#: 104448-53-5
Chemical Formula: C28H28N4O6S
Exact Mass: 548.17296
Molecular Weight: 548.61
Elemental Analysis: C, 61.30; H, 5.14; N, 10.21; O, 17.50; S, 5.84


Synonym: ICI 198615; ICI-198615; ICI198615; ICI-198,615; ZM 198615; ZM-198615.

IUPAC/Chemical Name: (1-((2-Methoxy-4-(((phenylsulfonyl)amino)carbonyl)phenyl)methyl)-1H-indazol-6-yl)carbamic acid cyclopentyl ester

InChi Key: YRCPIXCRSAKRGM-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H28N4O6S/c1-37-26-15-19(27(33)31-39(35,36)24-9-3-2-4-10-24)11-12-21(26)18-32-25-16-22(14-13-20(25)17-29-32)30-28(34)38-23-7-5-6-8-23/h2-4,9-17,23H,5-8,18H2,1H3,(H,30,34)(H,31,33)

SMILES Code: O=C(OC1CCCC1)NC2=CC3=C(C=C2)C=NN3CC4=CC=C(C(NS(=O)(C5=CC=CC=C5)=O)=O)C=C4OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Uchida Y, Hamada M, Kameyama M, Ohse H, Nomura A, Hasegawa S, Hirata F. ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Biochem Biophys Res Commun. 1992 Mar 31;183(3):1197-202. PubMed PMID: 1567397.

2: Smith EF 3rd, Slivjak MJ. ICI 198615 is an antagonist of leukotriene C4, leukotriene D4 and leukotriene E4 vasopressor responses in the conscious rat. Pharmacology. 1990;41(2):57-66. PubMed PMID: 2175920.