L-165041
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406801

CAS#: 79558-09-1

Description: L-165041, also known as L-165,041, is a potent and selective agonist of the nuclear receptor PPARβ/δ (Ki = 9 nM, EC50 = ~500 nM for hPPARβ/δ). L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism. L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ. L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle.


Price and Availability

Size
Price

5mg
USD 320
Size
Price

25mg
USD 920
Size
Price

L-165041, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406801
Name: L-165041
CAS#: 79558-09-1
Chemical Formula: C22H26O7
Exact Mass: 402.1679
Molecular Weight: 402.443
Elemental Analysis: Elemental Analysis: C, 65.66; H, 6.51; O, 27.83


Synonym: L-165041; L165041; L 165041; L-165,041; L165,041; L 165,041.

IUPAC/Chemical Name: 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-acetic acid

InChi Key: HBBVCKCCQCQCTJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25)

SMILES Code: O=C(O)COC1=CC=C(OCCCOC2=CC=C(C(C)=O)C(O)=C2CCC)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Roche E, Lascombe I, Bittard H, Mougin C, Fauconnet S. The PPARβ agonist
L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a
receptor-independent mechanism. Cell Signal. 2014 Feb;26(2):433-43. doi:
10.1016/j.cellsig.2013.10.006. Epub 2013 Oct 28. PubMed PMID: 24172859.

2: Park JH, Lee KS, Lim HJ, Kim H, Kwak HJ, Park HY. The PPARδ ligand L-165041
inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related
to PPARδ. J Cell Biochem. 2012 Jun;113(6):1947-54. doi: 10.1002/jcb.24063. PubMed
PMID: 22234939.

3: Lim HJ, Park JH, Lee S, Choi HE, Lee KS, Park HY. PPARdelta ligand L-165041
ameliorates Western diet-induced hepatic lipid accumulation and inflammation in
LDLR-/- mice. Eur J Pharmacol. 2009 Nov 10;622(1-3):45-51. doi:
10.1016/j.ejphar.2009.09.002. Epub 2009 Sep 18. PubMed PMID: 19766624.

4: Lim HJ, Lee S, Park JH, Lee KS, Choi HE, Chung KS, Lee HH, Park HY. PPAR delta
agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and
migration via inhibition of cell cycle. Atherosclerosis. 2009 Feb;202(2):446-54.
doi: 10.1016/j.atherosclerosis.2008.05.023. Epub 2008 May 21. PubMed PMID:
18585719.