Haloxazolam

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525255

CAS#: 59128-97-1

Description: Haloxazolam is a drug which is a benzodiazepine derivative. It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam. Haloxazolam is used for the treatment insomnia.


Price and Availability

Size
Price

Size
Price

Size
Price

Haloxazolam is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 525255
Name: Haloxazolam
CAS#: 59128-97-1
Chemical Formula: C17H14BrFN2O2
Exact Mass: 376.02227
Molecular Weight: 377.21
Elemental Analysis: C, 54.13; H, 3.74; Br, 21.18; F, 5.04; N, 7.43; O, 8.48


Synonym: Haloxazolam; Haloxazolamum; Haloxazolamum [INN-Latin]; Somelin; CS 430; CS-430; CS430.

IUPAC/Chemical Name: 10-Bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one

InChi Key: XDKCGKQHVBOOHC-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

SMILES Code: c1ccc(c(c1)C23c4cc(ccc4NC(=O)CN2CCO3)Br)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tan X, Uchida S, Matsuura M, Nishihara K, Kojima T. Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra. Psychiatry Clin Neurosci. 2003 Feb;57(1):97-104. PubMed PMID: 12519461.

2: Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O. Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine. J Anal Toxicol. 1999 Jan-Feb;23(1):54-61. PubMed PMID: 10022210.

3: Tanaka E, Terada M, Misawa S, Wakasugi C. Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel. J Chromatogr B Biomed Appl. 1996 Jun 28;682(1):173-8. Erratum in: J Chromatogr B Biomed Appl 1998 May 29;709(2):324. PubMed PMID: 8832439.

4: Miller BL, Bonner WA. Enantioselective autocatalysis. III. Configurational and conformational studies on a 1,4-benzodiazepinooxazole derivative. Orig Life Evol Biosph. 1995 Dec;25(6):539-47. PubMed PMID: 11536711.

5: Bonner WA. Enantioselective autocatalysis. II. Racemization studies on a 1,4-benzodiazepinooxazole derivative. Orig Life Evol Biosph. 1995 Aug;25(4):401-14. PubMed PMID: 11536705.

6: Otsubo K, Seto H, Futagami K, Oishi R. Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography. J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):408-12. PubMed PMID: 7581920.

7: Rodríguez FJ, Jiménez RM, Alonso RM. Separation and determination of aminohalogenbenzophenones by high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1992 Jul 1;578(1):146-51. PubMed PMID: 1400781.

8: Kuwayama T, Kurono Y, Muramatsu T, Yashiro T, Ikeda K. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):320-6. PubMed PMID: 2870816.

9: Kuwayama T, Yashiro T. [The behavior of 1,4-benzodiazepine drugs in the acidic media. I. Proton and carbon 13 nuclear magnetic resonance spectra of oxazolam, cloxazolam and haloxazolam in the acidic media]. Yakugaku Zasshi. 1984 Jun;104(6):607-13. Japanese. PubMed PMID: 6150102.

10: Sakai Y. Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems. Jpn J Pharmacol. 1983 Oct;33(5):1017-25. PubMed PMID: 6139494.