Garenoxacin mesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525151

CAS#: 223652-82-2

Description: Garenoxacin mesylate is a novel oral des-fluoro quinolone with potent antimicrobial activity against common respiratory pathogens, including resistant strains and Gram-positive and Gram-negative bacterial infections.


Price and Availability

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Garenoxacin mesylate is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525151
Name: Garenoxacin mesylate
CAS#: 223652-82-2
Chemical Formula: C24H24F2N2O7S
Exact Mass:
Molecular Weight: 522.52
Elemental Analysis: C, 55.17; H, 4.63; F, 7.27; N, 5.36; O, 21.43; S, 6.14


Synonym: Garenoxacin mesylate; BMS 284756; BM-284756; BMS284756; Garenoxacin mesilate.

IUPAC/Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-7-((1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl)-1,4-dihydro-4-oxo-, monomethanesulfonate

InChi Key: UPHLDCUEQOTSAD-RFVHGSKJSA-N

InChi Code: InChI=1S/C23H20F2N2O4.CH4O3S/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30;1-5(2,3)4/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30);1H3,(H,2,3,4)/t11-;/m1./s1

SMILES Code: n1(cc(c(=O)c2ccc(c(c12)OC(F)F)c1cc2CN[C@@H](c2cc1)C)C(=O)O)C1CC1.CS(=O)(=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Takagi H, Tanaka K, Tsuda H, Kobayashi H. Clinical studies of garenoxacin. Int J Antimicrob Agents. 2008 Dec;32(6):468-74. doi: 10.1016/j.ijantimicag.2008.06.032. Epub 2008 Sep 13. Review. PubMed PMID: 18790608.