ML-281
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MedKoo CAT#: 406783

CAS#: 1404437-62-2

Description: ML-281 is a potent ans selective STK33 inhibitor (IC50 = 14 nM). ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. ML281 is a valuable addition to small-molecule probes of STK33. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 2250
Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 3950
Size
Price

50mg
USD 250
500mg
USD 1350
5g
Ask price

ML-281, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406783
Name: ML-281
CAS#: 1404437-62-2
Chemical Formula: C22H19N3O2S
Exact Mass: 389.1198
Molecular Weight: 389.473
Elemental Analysis: C, 67.85; H, 4.92; N, 10.79; O, 8.22; S, 8.23


Synonym: ML-281; ML-281; ML281.

IUPAC/Chemical Name: N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide

SMILES Code: O=C(C1=CC=CS1)NC2=CC=C(C(C)C)C=C2C3=NC4=C(C=CC=C4)NC3=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, Silkworth W,
Dandapani S, Munoz B, Palmer M, Scherer C, Schreiber SL. Screen for Inhibitors of
STK33 Kinase Activity. 2011 Dec 16 [updated 2014 May 13]. Probe Reports from the
NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for
Biotechnology Information (US); 2010-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK133418/
PubMed PMID: 23658944.

2: Weïwer M, Spoonamore J, Wei J, Guichard B, Ross NT, Masson K, Silkworth W,
Dandapani S, Palmer M, Scherer CA, Stern AM, Schreiber SL, Munoz B. A Potent and
Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality
in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub
2012 Oct 22. PubMed PMID: 23256033; PubMed Central PMCID: PMC3523537.