Medicinal chemistry

Custom synthesis

MedKoo's medicinal chemistry services

Our goal in mediicnal chemistry service is to help your company to accelerate your discovery and development efforts at low cost with superior quality.

For early-stage start-up companies, we can serve as your medicinal chemistry department. Our staff is experienced in interacting with biology, pharmacology, legal/IP.  We can be your reliable source for medicinal chemistry expertise and synthesis.  For companies with internal chemistry labs, we can help you by preparing advanced intermediates, exploring SAR, working on back-up compounds, broadening the coverage of chemical space, or helping solve issues with ADME or physico-chemical properties.

 Our scientists have expertise in all phases of medicinal chemistry from early stage hit generation to late stage lead optimization. Our experience ranges from project inception and resource identification to synthetic route planning and library synthesis. Whether it's re-synthesis of a hit for validation or exploring the SAR of a lead compound, we have the experience and resources to accomplish the task.

Our Medchem services include, but not limited to:

Synthetic lead libraries

Synthesis of targeted molecular library

1D and 2D SAR development

Lead optimization

Optimization of ADME such as reducing side-effect, enhancing bioactivity and bioavailability, improving solubility.

Synthesis of metabolite and stable isotopes

Cold route designing and scouting in support of the synthesis of radiolabled APIs

Bioconjugate synthesis: covalently homo- or hetero- cross-linking small molecules with biopolymers such as protein, antibody, enzyme.

Biopolymer labeling: attach an molecular probe to a  protein, antibody or enzyme

Contact MedKoo:

Email: sales@medkoo.com

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