MedKoo Biosciences

About us  |  Services  |  Products  |  News  |  Careers  |  Contact us

 

 

 

 

Back to products

 

Browse products

Approved anticancer agents

Anticancer agents in trials

Anticancer molecular libraries

 


Other drug agents

Drug intermediates

Bio-reagents and biochemicals

 

 

 

 

 

 

 

 

 

MedKoo product information:

Totrombopag

MedKoo Code#: 202963

Name: Totrombopag

CAS#: 376592-42-6

 

Synonym:   SB-559448; 3H-Pyrazol-3-one, 2-(3,4-dimethylphenyl)-2,4-dihydro-4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]diazenyl]-5-methyl-; H-Pyrazol-3-one, 2-(3,4-dimethylphenyl)-2,4-dihydro-4-[[2-hydroxy-3'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]azo]-5-methyl-;    (4Z)-2-(3,4-dimethylphenyl)-4-(2-{2-hydroxy-3'-(1H-tetrazol-5-yl)[1,1'-biphenyl-3-yl]}hydrazinylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one.

 

 

IUPAC/Chemical name: 

(E)-1-(3,4-dimethylphenyl)-4-((2-hydroxy-3'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)diazenyl)-3-methyl-1H-pyrazol-5(4H)-one.

 

Chemical structure: Theoretical analysis

 

 

 

Chemical Formula: C25H22N8O2

Exact Mass: 466.18657

Molecular Weight: 466.49

 

m/z: 466.18657 (100.0%), 467.18993 (27.0%), 468.19328 (3.5%), 467.18361 (3.0%)

 

Elemental Analysis: C, 64.37; H, 4.75; N, 24.02; O, 6.86

 

Availability and price:

This agent is not in stock, which may be available through custom synthesis.

 

  To inquire quotation and lead time or to ask questions, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer big discount for orders of bulk quantities.

 

Quality control data:

Product will be shipped with supporting analytical data.

 

 

Information about this agent

 Totrombopag is being developed by GlaxoSmithKline, which a back-up compound for eltrombopag (SB-497115) .

 

Current developer:    GlaxoSmithKline

 

References

Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor. Alper, Phil B.; Marsilje, Thomas H.; Mutnick, Daniel; Lu, Wenshuo; Chatterjee, Arnab; Roberts, Michael J.; He, Yun; Karanewsky, Donald S.; Chow, Donald; Lao, Jianmin; Gerken, Andrea; Tuntland, Tove; Liu, Bo; Chang, Jonathan; Gordon, Perry; Seidel, H. Martin; Tian, Shin-Shay. Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA. Bioorganic & Medicinal Chemistry Letters (2008), 18(19), 5255-5258. Publisher: Elsevier Ltd., CODEN: BMCLE8 ISSN: 0960-894X. Journal written in English. CAN 149:548251 AN 2008:1138522 CAPLUS

 

 

 

Contact MedKoo:

Email: sales@medkoo.com

 

(Keyword; CAS#; MedKoo code#)

 

 

 

 

 

 

 

About us  |  Services  |  Products  |  News  |  Careers  |  Contact us

© MedKoo Biosciences. All Rights Reserved