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MedKoo product information:
Totrombopag
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MedKoo Code#: 202963
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Name:
Totrombopag
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CAS#:
376592-42-6
Synonym: SB-559448;
3H-Pyrazol-3-one,
2-(3,4-dimethylphenyl)-2,4-dihydro-4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]diazenyl]-5-methyl-;
H-Pyrazol-3-one,
2-(3,4-dimethylphenyl)-2,4-dihydro-4-[[2-hydroxy-3'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]azo]-5-methyl-;
(4Z)-2-(3,4-dimethylphenyl)-4-(2-{2-hydroxy-3'-(1H-tetrazol-5-yl)[1,1'-biphenyl-3-yl]}hydrazinylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one.
IUPAC/Chemical name:
(E)-1-(3,4-dimethylphenyl)-4-((2-hydroxy-3'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)diazenyl)-3-methyl-1H-pyrazol-5(4H)-one.
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Chemical structure: |
Theoretical analysis
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Chemical Formula: C25H22N8O2
Exact Mass: 466.18657
Molecular Weight: 466.49
m/z: 466.18657 (100.0%), 467.18993 (27.0%),
468.19328 (3.5%), 467.18361 (3.0%)
Elemental Analysis: C, 64.37; H, 4.75; N,
24.02; O, 6.86
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Availability and price:
This agent is not in stock, which may be available through custom synthesis.
To inquire quotation and lead time or to ask questions, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
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Quality control
data:
Product will be shipped with
supporting analytical data.
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Information about this agent
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Totrombopag
is being developed by
GlaxoSmithKline, which a back-up compound for
eltrombopag (SB-497115)
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Current developer:
GlaxoSmithKline
Discovery and biological evaluation of benzo[a]carbazole-based
small molecule agonists of the thrombopoietin (Tpo) receptor. Alper,
Phil B.; Marsilje, Thomas H.; Mutnick, Daniel; Lu, Wenshuo; Chatterjee,
Arnab; Roberts, Michael J.; He, Yun; Karanewsky, Donald S.; Chow,
Donald; Lao, Jianmin; Gerken, Andrea; Tuntland, Tove; Liu, Bo; Chang,
Jonathan; Gordon, Perry; Seidel, H. Martin; Tian, Shin-Shay. Genomics
Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA.
Bioorganic & Medicinal Chemistry Letters (2008), 18(19), 5255-5258.
Publisher: Elsevier Ltd., CODEN: BMCLE8 ISSN: 0960-894X. Journal written
in English. CAN 149:548251 AN 2008:1138522 CAPLUS
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Contact MedKoo:
Email:
sales@medkoo.com
(Keyword; CAS#; MedKoo code#)
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