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MedKoo product information:

 

Timcodar

 

Description of Timcodar: Timcodar, also known as VX-853,  is a Novel Multidrug Resistance Inhibitor. Timcodar was under clinical trials to treat cancaners and other diseases. Timcodar potentiated the activity of ethidium bromide (EtBr), a model efflux substrate, against three clinically significant gram-positive pathogens: Staphylococcus aureus, Enterococcus faecalis, and Streptococcus pneumoniae. Similar to reserpine,  VX-853 directly blocked EtBr efflux in S. aureus. Furthermore, VX-853 was  effective in lowering the MICs of several clinically used antibiotics, including fluoroquinolones, suggesting that  VX-853 are representatives of a new class of bacterial efflux inhibitors with the potential for use in combination therapy. [source: Antimicrob Agents Chemother. 2004 Nov;48(11):4171-6.]

 

Current developer:    Vertex (Originator).

 

MedKoo Cat#:  202926

Name:  Timcodar

CAS#:  183313-30-6, 179033-51-3 (free base).

   

Synonym:   Timcodar dimesilate, VX-853. 

  

IUPAC/Chemical name: 

(S)-N-benzyl-3-(4-chlorophenyl)-N-(1,5-di(pyridin-4-yl)pentan-3-yl)-2-(N-methyl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetamido)propanamide dimethanesulfonate

    

Chemical structure

Theoretical analysis

 

 

 

Timcodar (free base)

Chemical Formula: C43H45ClN4O6

Exact Mass: 748.30276

Molecular Weight: 749.29

Elemental Analysis: C, 68.93; H, 6.05; Cl, 4.73; N, 7.48; O, 12.81

   

Timcodar dimesylate

Chemical Formula: C45H53ClN4O12S2

Molecular Weight: 941.5

Elemental Analysis: C, 57.41; H, 5.67; Cl, 3.77; N, 5.95; O, 20.39; S, 6.81

   

 

Availability and price:

 

Timcodar is available through custom synthesis

 

To inquire quotation and lead time or to ask questions, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer big discount for orders of bulk quantities. 

 

Information about this agent

  

 

References

1: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Oct;28(8):533-91. PubMed PMID: 17136234.

2: Hahn K, Sirdofsky M, Brown A, Ebenezer G, Hauer P, Miller C, Polydefkis M. Collateral sprouting of human epidermal nerve fibers following intracutaneous axotomy. J Peripher Nerv Syst. 2006 Jun;11(2):142-7. PubMed PMID: 16787512.

3: Polydefkis M, Sirdofsky M, Hauer P, Petty BG, Murinson B, McArthur JC. Factors influencing nerve regeneration in a trial of timcodar dimesylate. Neurology. 2006 Jan 24;66(2):259-61. PubMed PMID: 16434669.

4: Mitchell AM, Tom M, Mortimer RH. Thyroid hormone export from cells: contribution of P-glycoprotein. J Endocrinol. 2005 Apr;185(1):93-8. PubMed PMID: 15817830.

5: Mullin S, Mani N, Grossman TH. Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853). Antimicrob Agents Chemother. 2004 Nov;48(11):4171-6. PubMed PMID: 15504837; PubMed Central PMCID: PMC525397.

   

 

 

 

Contact MedKoo:

Tel: 919-636-5577
Fax: 919-980-4831
Email: sales@medkoo.com

 

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