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Resveratrol

Resveratrol is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Resveratrol new formulation: Sirtris Pharmaceuticals  is currently deeloping a resveratrol formulation, called SRT501, which is a proprietary formulation of resveratrol, a polyphenolic phytoalexin derived from grapes and other food products with potential antioxidant, anti-obesity, antidiabetic and chemopreventive activities. Resveratrol may activate sirtuin subtype 1 (SIRT-1). SIRT1 activation has been reported to inhibit tumorigenesis and tumor cell proliferation. SIRT-1 is a member of the silent information regulator 2 (SIR2) (or sirtuin) family of enzymes that plays an important role in mitochondrial activity and acts as a protein deacetylase. SIRT1 appears to be involved in the regulation of numerous transcription factors such as Nf-kB and p53. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) .

SRT501 is Sirtris's  proprietary formulation of resveratrol with improved bioavailability. In Phase I human clinical trials, SRT501 was found to be safe and well tolerated. In Phase II human clinical trials, SRT501 also lowered glucose and improved insulin sensitivity in patients with Type 2 Diabetes. Sirtris are currently testing SRT501 in a Phase II trial in oncology; new patient enrollment is currently suspended. see http://www.sirtrispharma.com/pipeline-SRT501.html.

Current developer:    Sirtris Pharmaceuticals

1: Fang Y, Herrick EJ, Nicholl MB. A Possible Role for Perforin and Granzyme B in Resveratrol Enhanced Radiosensitivity of Prostate Cancer. J Androl. 2011 Nov 17. [Epub ahead of print] PubMed PMID: 22096086.

2: Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, Dayes I, Lukka H, Wright J, Tsakiridis T. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. Radiat Oncol. 2011 Oct 26;6:144. PubMed PMID: 22029423; PubMed Central PMCID: PMC3217881.

3: Kai L, Levenson AS. Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells. Anticancer Res. 2011 Oct;31(10):3323-30. PubMed PMID: 21965742.

4: Lee MF, Pan MH, Chiou YS, Cheng AC, Huang H. Resveratrol Modulates MED28 (Magicin/EG-1) Expression and Inhibits Epidermal Growth Factor (EGF)-Induced Migration in MDA-MB-231 Human Breast Cancer Cells. J Agric Food Chem. 2011 Nov 9;59(21):11853-61. Epub 2011 Oct 17. PubMed PMID: 21942447.

5: Johnson WD, Morrissey RL, Usborne AL, Kapetanovic I, Crowell JA, Muzzio M, McCormick DL. Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity. Food Chem Toxicol. 2011 Dec;49(12):3319-27. Epub 2011 Sep 10. PubMed PMID: 21939727; PubMed Central PMCID: PMC3223276.

6: Nutakul W, Sobers HS, Qiu P, Dong P, Decker EA, McClements DJ, Xiao H. Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. J Agric Food Chem. 2011 Oct 26;59(20):10964-70. Epub 2011 Sep 29. PubMed PMID: 21936500; PubMed Central PMCID: PMC3201709.

7: Mohapatra P, Preet R, Choudhuri M, Choudhuri T, Kundu CN. 5-fluorouracil increases the chemopreventive potentials of resveratrol through DNA damage and MAPK signaling pathway in human colorectal cancer cells. Oncol Res. 2011;19(7):311-21. PubMed PMID: 21936401.

8: Bae S, Lee EM, Cha HJ, Kim K, Yoon Y, Lee H, Kim J, Kim YJ, Lee HG, Jeung HK, Min YH, An S. Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells. Mol Cells. 2011 Sep;32(3):243-9. Epub 2011 Aug 29. PubMed PMID: 21887509.

9: Santandreu FM, Valle A, Oliver J, Roca P. Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. Cell Physiol Biochem. 2011;28(2):219-28. Epub 2011 Aug 16. PubMed PMID: 21865729.

10: Soto BL, Hank JA, Darjatmoko SR, Polans AS, Yanke EM, Rakhmilevich AL, Seo S, Kim K, Reisfeld RA, Gillies SD, Sondel PM. Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy. Int Immunopharmacol. 2011 Nov;11(11):1877-86. Epub 2011 Aug 18. PubMed PMID: 21854876; PubMed Central PMCID: PMC3204008.

11: Vanamala J, Radhakrishnan S, Reddivari L, Bhat VB, Ptitsyn A. Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach. Proteome Sci. 2011 Aug 17;9(1):49. PubMed PMID: 21849056; PubMed Central PMCID: PMC3175442.

12: Tili E, Michaille JJ. Resveratrol, MicroRNAs, Inflammation, and Cancer. J Nucleic Acids. 2011;2011:102431. Epub 2011 Aug 10. PubMed PMID: 21845215; PubMed Central PMCID: PMC3154569.

13: Stefanska B, Salamé P, Bednarek A, Fabianowska-Majewska K. Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2011 Aug 1:1-10. [Epub ahead of print] PubMed PMID: 21801466.

14: Zhou JH, Cheng HY, Yu ZQ, He DW, Pan Z, Yang DT. Resveratrol induces apoptosis in pancreatic cancer cells. Chin Med J (Engl). 2011 Jun;124(11):1695-9. PubMed PMID: 21740780.

15: De Amicis F, Giordano F, Vivacqua A, Pellegrino M, Panno ML, Tramontano D, Fuqua SA, Andò S. Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor alpha gene expression via p38MAPK/CK2 signaling in human breast cancer cells. FASEB J. 2011 Oct;25(10):3695-707. Epub 2011 Jul 7. PubMed PMID: 21737614; PubMed Central PMCID: PMC3177579.

16: Dhar S, Hicks C, Levenson AS. Resveratrol and prostate cancer: promising role for microRNAs. Mol Nutr Food Res. 2011 Aug;55(8):1219-29. doi: 10.1002/mnfr.201100141. Epub 2011 Jun 29. PubMed PMID: 21714127.

17: Yang R, Zhang H, Zhu L. Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal cancer cells. Mol Med Report. 2011 Sep-Oct;4(5):981-3. doi: 10.3892/mmr.2011.511. Epub 2011 Jun 17. PubMed PMID: 21687947.

18: Shamim U, Hanif S, Albanyan A, Beck FW, Bao B, Wang Z, Banerjee S, Sarkar FH, Mohammad RM, Hadi SM, Azmi AS. Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer. J Cell Physiol. 2011 Jun 15. doi: 10.1002/jcp.22865. [Epub ahead of print] PubMed PMID: 21678400; PubMed Central PMCID: PMC3185178.

19: Shadfar S, Couch ME, McKinney KA, Weinstein LJ, Yin X, Rodríguez JE, Guttridge DC, Willis M. Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo. Nutr Cancer. 2011;63(5):749-62. Epub 2011 Jun 9. PubMed PMID: 21660860.

20: Radhakrishnan S, Reddivari L, Sclafani R, Das UN, Vanamala J. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Front Biosci (Elite Ed). 2011 Jun 1;3:1509-23. PubMed PMID: 21622155.

21: Wang XX, Li YB, Yao HJ, Ju RJ, Zhang Y, Li RJ, Yu Y, Zhang L, Lu WL. The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells. Biomaterials. 2011 Aug;32(24):5673-87. Epub 2011 May 7. PubMed PMID: 21550109.

22: Shi Y, Yang S, Troup S, Lu X, Callaghan S, Park DS, Xing Y, Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncol Rep. 2011 Jun;25(6):1713-9. doi: 10.3892/or.2011.1248. Epub 2011 Apr 6. PubMed PMID: 21479363.

23: Colin D, Limagne E, Jeanningros S, Jacquel A, Lizard G, Athias A, Gambert P, Hichami A, Latruffe N, Solary E, Delmas D. Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells. Cancer Prev Res (Phila). 2011 Jul;4(7):1095-106. Epub 2011 Apr 5. PubMed PMID: 21467134.

24: Kaminski BM, Steinhilber D, Stein JM, Ulrich S. Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional Cancer Therapies. Curr Pharm Biotechnol. 2011 Apr 5. [Epub ahead of print] PubMed PMID: 21466425.

25: Jeong NY, Yoon YG, Rho JH, Lee JS, Lee SY, Yoo KS, Song S, Suh H, Choi YH, Yoo YH. The novel resveratrol analog HS-1793-induced polyploid LNCaP prostate cancer cells are vulnerable to downregulation of Bcl-xL. Int J Oncol. 2011 Jun;38(6):1597-604. doi: 10.3892/ijo.2011.979. Epub 2011 Mar 17. PubMed PMID: 21424121.

26: Tang JJ, Fan GJ, Dai F, Ding DJ, Wang Q, Lu DL, Li RR, Li XZ, Hu LM, Jin XL, Zhou B. Finding more active antioxidants and cancer chemoprevention agents by elongating the conjugated links of resveratrol. Free Radic Biol Med. 2011 May 15;50(10):1447-57. Epub 2011 Mar 2. PubMed PMID: 21376113.

27: Horndasch M, Culig Z. SOCS-3 antagonizes pro-apoptotic effects of TRAIL and resveratrol in prostate cancer cells. Prostate. 2011 Sep;71(12):1357-66. doi: 10.1002/pros.21353. Epub 2011 Feb 9. PubMed PMID: 21308719.

28: Shankar S, Nall D, Tang SN, Meeker D, Passarini J, Sharma J, Srivastava RK. Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One. 2011 Jan 31;6(1):e16530. PubMed PMID: 21304978; PubMed Central PMCID: PMC3031576.

29: Ndiaye M, Kumar R, Ahmad N. Resveratrol in cancer management: where are we and where we go from here? Ann N Y Acad Sci. 2011 Jan;1215:144-9. doi: 10.1111/j.1749-6632.2010.05851.x. Review. PubMed PMID: 21261653.

30: Shukla Y, Singh R. Resveratrol and cellular mechanisms of cancer prevention. Ann N Y Acad Sci. 2011 Jan;1215:1-8. doi: 10.1111/j.1749-6632.2010.05870.x. Review. PubMed PMID: 21261635.

31: Jäger W, Gruber A, Giessrigl B, Krupitza G, Szekeres T, Sonntag D. Metabolomic analysis of resveratrol-induced effects in the human breast cancer cell lines MCF-7 and MDA-MB-231. OMICS. 2011 Jan-Feb;15(1-2):9-14. Epub 2011 Jan 17. PubMed PMID: 21241168.

32: Hsieh TC, Wong C, John Bennett D, Wu JM. Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3. Int J Cancer. 2011 Dec 1;129(11):2732-43. doi: 10.1002/ijc.25930. Epub 2011 Mar 11. PubMed PMID: 21225623.

33: Ganapathy S, Chen Q, Singh KP, Shankar S, Srivastava RK. Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS One. 2010 Dec 28;5(12):e15627. PubMed PMID: 21209944; PubMed Central PMCID: PMC3011015.

34: Mehdawi H, Alkhalaf M, Khan I. Role of Na(+)/H (+) exchanger in resveratrol-induced growth inhibition of human breast cancer cells. Med Oncol. 2010 Dec 30. [Epub ahead of print] PubMed PMID: 21191669.

35: Pandey PR, Okuda H, Watabe M, Pai SK, Liu W, Kobayashi A, Xing F, Fukuda K, Hirota S, Sugai T, Wakabayashi G, Koeda K, Kashiwaba M, Suzuki K, Chiba T, Endo M, Fujioka T, Tanji S, Mo YY, Cao D, Wilber AC, Watabe K. Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Res Treat. 2011 Nov;130(2):387-98. Epub 2010 Dec 29. PubMed PMID: 21188630.

36: Marimuthu P, Kaur K, Kandalam U, Jasani V, Bukhari N, Nguyen M, Abdul A, Pervez FF, Rathinavelu A. Treatment of ovarian cancer cells with nutlin-3 and resveratrol combination leads to apoptosis via caspase activation. J Med Food. 2011 Jan-Feb;14(1-2):46-52. Epub 2010 Dec 27. PubMed PMID: 21186985.

37: Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol. 2011 May;18(5):1506-11. Epub 2010 Dec 24. PubMed PMID: 21184191; PubMed Central PMCID: PMC3078954.

38: Chen Q, Ganapathy S, Singh KP, Shankar S, Srivastava RK. Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One. 2010 Dec 14;5(12):e15288. PubMed PMID: 21179458; PubMed Central PMCID: PMC3001855.

39: He X, Wang Y, Zhu J, Orloff M, Eng C. Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett. 2011 Feb 28;301(2):168-76. Epub 2010 Dec 17. PubMed PMID: 21168265.

40: Cui J, Sun R, Yu Y, Gou S, Zhao G, Wang C. Antiproliferative effect of resveratrol in pancreatic cancer cells. Phytother Res. 2010 Nov;24(11):1637-44. doi: 10.1002/ptr.3157. PubMed PMID: 21031621.

41: Oi N, Jeong CH, Nadas J, Cho YY, Pugliese A, Bode AM, Dong Z. Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase. Cancer Res. 2010 Dec 1;70(23):9755-64. Epub 2010 Oct 15. PubMed PMID: 20952510.

42: Lubbers J, Lewis S, Harper E, Hledin MP, Marquez GA, Johnson AE, Graves DR, Burnatowska-Hledin MA. Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells. Cell Biol Toxicol. 2011 Apr;27(2):95-105. Epub 2010 Oct 15. PubMed PMID: 20949323.

43: Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010 Nov 15;70(22):9003-11. Epub 2010 Oct 8. PubMed PMID: 20935227; PubMed Central PMCID: PMC2982884.

44: Zahid M, Saeed M, Beseler C, Rogan EG, Cavalieri EL. Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells. Free Radic Biol Med. 2011 Jan 1;50(1):78-85. Epub 2010 Oct 8. PubMed PMID: 20934508.

45: Patel VB, Misra S, Patel BB, Majumdar AP. Colorectal cancer: chemopreventive role of curcumin and resveratrol. Nutr Cancer. 2010;62(7):958-67. Review. PubMed PMID: 20924971.

46: Macpherson L, Matthews J. Inhibition of aryl hydrocarbon receptor-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor α expression in human breast cancer cells. Cancer Lett. 2010 Dec 28;299(2):119-29. Epub 2010 Sep 16. PubMed PMID: 20846786.

47: Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 2010 Oct 1;70(19):7392-9. Epub 2010 Sep 14. PubMed PMID: 20841478; PubMed Central PMCID: PMC2948608.

48: Wang Y, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C. Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines. Hum Mol Genet. 2010 Nov 15;19(22):4319-29. Epub 2010 Aug 20. PubMed PMID: 20729295; PubMed Central PMCID: PMC2957324.

49: Fulda S. Resveratrol and derivatives for the prevention and treatment of cancer. Drug Discov Today. 2010 Sep;15(17-18):757-65. Epub 2010 Aug 6. Review. PubMed PMID: 20692359.

50: Papoutsis AJ, Lamore SD, Wondrak GT, Selmin OI, Romagnolo DF. Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells. J Nutr. 2010 Sep;140(9):1607-14. Epub 2010 Jul 14. PubMed PMID: 20631324; PubMed Central PMCID: PMC3139234.

51: Fukui M, Yamabe N, Kang KS, Zhu BT. Growth-stimulatory effect of resveratrol in human cancer cells. Mol Carcinog. 2010 Aug;49(8):750-9. PubMed PMID: 20572158.

52: Sun B, Hoshino J, Jermihov K, Marler L, Pezzuto JM, Mesecar AD, Cushman M. Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. Epub 2010 May 24. PubMed PMID: 20558073; PubMed Central PMCID: PMC2903642.

53: Mao QQ, Bai Y, Lin YW, Zheng XY, Qin J, Yang K, Xie LP. Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell lines. Mol Nutr Food Res. 2010 Nov;54(11):1574-84. PubMed PMID: 20521268.

54: Vanamala J, Reddivari L, Radhakrishnan S, Tarver C. Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer. 2010 May 26;10:238. PubMed PMID: 20504360; PubMed Central PMCID: PMC2891636.

55: Guha P, Dey A, Dhyani MV, Sen R, Chatterjee M, Chattopadhyay S, Bandyopadhyay SK. Calpain and caspase orchestrated death signal to accomplish apoptosis induced by resveratrol and its novel analog hydroxystilbene-1 [correction of hydroxstilbene-1] in cancer cells. J Pharmacol Exp Ther. 2010 Aug;334(2):381-94. Epub 2010 May 18. PubMed PMID: 20484155.

56: Kraft TE, Parisotto D, Schempp C, Efferth T. Fighting cancer with red wine? Molecular mechanisms of resveratrol. Crit Rev Food Sci Nutr. 2009 Oct;49(9):782-99. Review. PubMed PMID: 20443159.

57: Hofseth LJ, Singh UP, Singh NP, Nagarkatti M, Nagarkatti PS. Taming the beast within: resveratrol suppresses colitis and prevents colon cancer. Aging (Albany NY). 2010 Apr;2(4):183-4. PubMed PMID: 20436227; PubMed Central PMCID: PMC2881508.

58: Cui X, Jin Y, Hofseth AB, Pena E, Habiger J, Chumanevich A, Poudyal D, Nagarkatti M, Nagarkatti PS, Singh UP, Hofseth LJ. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prev Res (Phila). 2010 Apr;3(4):549-59. Epub 2010 Mar 23. PubMed PMID: 20332304; PubMed Central PMCID: PMC2853724.

59: Alfaras I, Pérez M, Juan ME, Merino G, Prieto JG, Planas JM, Alvarez AI. Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice. J Agric Food Chem. 2010 Apr 14;58(7):4523-8. PubMed PMID: 20232796.

60: Fukui M, Yamabe N, Zhu BT. Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. Eur J Cancer. 2010 Jul;46(10):1882-91. Epub 2010 Mar 10. PubMed PMID: 20223651; PubMed Central PMCID: PMC2911364.

61: Morris JC. Resveratrol, thyroid cancer, and iodide: drink up? Thyroid. 2010 Feb;20(2):125-6. PubMed PMID: 20151819.

62: Parekh P, Motiwale L, Naik N, Rao KV. Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells. Exp Toxicol Pathol. 2011 Jan;63(1-2):167-73. Epub 2010 Feb 4. PubMed PMID: 20133117.

63: Hadi SM, Ullah MF, Azmi AS, Ahmad A, Shamim U, Zubair H, Khan HY. Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer. Pharm Res. 2010 Jun;27(6):979-88. Epub 2010 Jan 30. Review. PubMed PMID: 20119749.

64: Wang TT, Schoene NW, Kim YS, Mizuno CS, Rimando AM. Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells. Mol Nutr Food Res. 2010 Mar;54(3):335-44. PubMed PMID: 20077416.

65: Wu JY, Tsai KW, Shee JJ, Li YZ, Chen CH, Chuang JJ, Liu YW. 4'-Chloro-3,5-dihydroxystilbene, a resveratrol derivative, induces lung cancer cell death. Acta Pharmacol Sin. 2010 Jan;31(1):81-92. PubMed PMID: 20048747.

66: Bai Y, Mao QQ, Qin J, Zheng XY, Wang YB, Yang K, Shen HF, Xie LP. Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. 2010 Feb;101(2):488-93. Epub 2009 Oct 27. PubMed PMID: 20028382.

67: Choi HY, Chong SA, Nam MJ. Resveratrol induces apoptosis in human SK-HEP-1 hepatic cancer cells. Cancer Genomics Proteomics. 2009 Sep-Oct;6(5):263-8. PubMed PMID: 19996131.

68: Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S, Aggarwal BB. Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. Int J Cancer. 2010 Jul 15;127(2):257-68. PubMed PMID: 19908231; PubMed Central PMCID: PMC3090706.

69: Majumdar AP, Banerjee S, Nautiyal J, Patel BB, Patel V, Du J, Yu Y, Elliott AA, Levi E, Sarkar FH. Curcumin synergizes with resveratrol to inhibit colon cancer. Nutr Cancer. 2009;61(4):544-53. PubMed PMID: 19838927.

70: Withdrawal of antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. J Med Chem. 2009 Oct 22;52(20):6504. PubMed PMID: 19827838.

71: Kai L, Samuel SK, Levenson AS. Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex. Int J Cancer. 2010 Apr 1;126(7):1538-48. PubMed PMID: 19810103.

72: Miksits M, Wlcek K, Svoboda M, Thalhammer T, Ellinger I, Stefanzl G, Falany CN, Szekeres T, Jaeger W. Expression of sulfotransferases and sulfatases in human breast cancer: impact on resveratrol metabolism. Cancer Lett. 2010 Mar 28;289(2):237-45. Epub 2009 Sep 10. PubMed PMID: 19747768.

73: Lee MH, Choi BY, Kundu JK, Shin YK, Na HK, Surh YJ. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009 Sep 15;69(18):7449-58. Epub 2009 Sep 8. PubMed PMID: 19738051.

74: Pettit GR, Melody N, Thornhill A, Knight JC, Groy TL, Herald CL. Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. J Nat Prod. 2009 Sep;72(9):1637-42. PubMed PMID: 19719153; PubMed Central PMCID: PMC2782413.

75: Pettit RK, Pettit GR, Hamel E, Hogan F, Moser BR, Wolf S, Pon S, Chapuis JC, Schmidt JM. E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. Bioorg Med Chem. 2009 Sep 15;17(18):6606-12. Epub 2009 Aug 4. PubMed PMID: 19709889.

76: Harper CE, Cook LM, Patel BB, Wang J, Eltoum IA, Arabshahi A, Shirai T, Lamartiniere CA. Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats. Prostate. 2009 Nov 1;69(15):1668-82. PubMed PMID: 19670229; PubMed Central PMCID: PMC2758814.

77: Lee SC, Chan JY, Pervaiz S. Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the threshold to resveratrol-evoked apoptosis in colon cancer cells. Cancer Lett. 2010 Feb 1;288(1):36-41. Epub 2009 Jul 17. PubMed PMID: 19616374.

78: Li H, Wu WK, Zheng Z, Che CT, Yu L, Li ZJ, Wu YC, Cheng KW, Yu J, Cho CH, Wang M. 2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, is a potent inducer of apoptosis in colon cancer cells via targeting microtubules. Biochem Pharmacol. 2009 Nov 1;78(9):1224-32. Epub 2009 Jul 8. PubMed PMID: 19591809.

79: Zhou R, Fukui M, Choi HJ, Zhu BT. Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection. Br J Pharmacol. 2009 Sep;158(2):462-74. Epub 2009 Jun 25. PubMed PMID: 19563536; PubMed Central PMCID: PMC2757685.

80: Lappano R, Rosano C, Madeo A, Albanito L, Plastina P, Gabriele B, Forti L, Stivala LA, Iacopetta D, Dolce V, Andò S, Pezzi V, Maggiolini M. Structure-activity relationships of resveratrol and derivatives in breast cancer cells. Mol Nutr Food Res. 2009 Jul;53(7):845-58. PubMed PMID: 19496085.

81: Cheson BD. Resveratrol and cancer prevention. Clin Adv Hematol Oncol. 2009 Mar;7(3):142. PubMed PMID: 19402261.

82: Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev Res (Phila). 2009 May;2(5):409-18. Epub 2009 Apr 28. Review. PubMed PMID: 19401532.

83: Signorelli P, Munoz-Olaya JM, Gagliostro V, Casas J, Ghidoni R, Fabriàs G. Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett. 2009 Sep 18;282(2):238-43. Epub 2009 Apr 25. PubMed PMID: 19394759.

84: Miksits M, Wlcek K, Svoboda M, Kunert O, Haslinger E, Thalhammer T, Szekeres T, Jäger W. Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells. Planta Med. 2009 Sep;75(11):1227-30. Epub 2009 Apr 6. PubMed PMID: 19350482.

85: Colin D, Gimazane A, Lizard G, Izard JC, Solary E, Latruffe N, Delmas D. Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells. Int J Cancer. 2009 Jun 15;124(12):2780-8. PubMed PMID: 19334045.

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