MedKoo product information:

  PHY-906

Chinese herbal formulation PHY906 is an oral traditional Chinese herbal formulation in powder form containing a spray dried aqueous extract from the herbs Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba and Paeonia lactiflora with potential immunomodulating and chemoprotective activities. Although the mechanism of actions remain to be fully elucidated, PHY906 possesses a wide range of pharmacological activities such as the enhancement of oral uptake of pharmacologically active agents, inhibition of CYP3A4, modulation of certain cytokines, macrophages and lymphocytes, and inhibition of expression of MMP, NF-kB, beta-glucuronidase, the NK-1 receptor, and the delta-opioid receptor. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Current developer:    PhytoCeutica.

1: Wang E, Bussom S, Chen J, Quinn C, Bedognetti D, Lam W, Guan F, Jiang Z, Mark Y, Zhao Y, Stroncek DF, White J, Marincola FM, Cheng YC. Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment. BMC Med Genomics. 2011 May 11;4:38. PubMed PMID: 21569348; PubMed Central PMCID: PMC3117677.

2: Lam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC. The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Sci Transl Med. 2010 Aug 18;2(45):45ra59. PubMed PMID: 20720216.

3: Zhang W, Saif MW, Dutschman GE, Li X, Lam W, Bussom S, Jiang Z, Ye M, Chu E, Cheng YC. Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS). J Chromatogr A. 2010 Sep 10;1217(37):5785-93. Epub 2010 Jul 21. PubMed PMID: 20696432.

4: Saif MW, Lansigan F, Ruta S, Lamb L, Mezes M, Elligers K, Grant N, Jiang ZL, Liu SH, Cheng YC. Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies. Phytomedicine. 2010 Mar;17(3-4):161-9. Epub 2010 Jan 22. PubMed PMID: 20092990.

5: Sze DM, Chan GC. Supplements for immune enhancement in hematologic malignancies. Hematology Am Soc Hematol Educ Program. 2009:313-9. Review. PubMed PMID: 20008216.

6: Yen Y, So S, Rose M, Saif MW, Chu E, Liu SH, Foo A, Jiang Z, Su T, Cheng YC. Phase I/II study of PHY906/capecitabine in advanced hepatocellular carcinoma. Anticancer Res. 2009 Oct;29(10):4083-92. PubMed PMID: 19846955.

7: Schornack S, Minsavage GV, Stall RE, Jones JB, Lahaye T. Characterization of AvrHah1, a novel AvrBs3-like effector from Xanthomonas gardneri with virulence and avirulence activity. New Phytol. 2008 Jul;179(2):546-56. PubMed PMID: 19086184.

8: Saif MW. Is there a role for herbal medicine in the treatment of pancreatic cancer?. Highlights from the "44th ASCO Annual Meeting". Chicago, IL, USA. May 30 - June 3, 2008. JOP. 2008 Jul 10;9(4):403-7. PubMed PMID: 18648130.

9: Claus MP, Lunardi M, Alfieri AF, Ferracin LM, Fungaro MH, Alfieri AA. Identification of unreported putative new bovine papillomavirus types in Brazilian cattle herds. Vet Microbiol. 2008 Dec 10;132(3-4):396-401. Epub 2008 Jul 9. PubMed PMID: 18617336.

10: Ye M, Liu SH, Jiang Z, Lee Y, Tilton R, Cheng YC. Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy. Rapid Commun Mass Spectrom. 2007;21(22):3593-607. PubMed PMID: 17944003.

11: Farrell MP, Kummar S. Phase I/IIA randomized study of PHY906, a novel herbal agent, as a modulator of chemotherapy in patients with advanced colorectal cancer. Clin Colorectal Cancer. 2003 Feb;2(4):253-6. PubMed PMID: 12620148.