MK-8033 | CAS#1196681-38-5 | MedKoo Biosciences

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MK-8033

Description of MK8033: MK8033 is a selective small-molecule inhibitor, ATP competitive. Phase I investigation of the cMet inhibitor MK-8033 is ongoing. Plans include a trial of this agent in refractory colorectal cancer, with pre- and post-treatment biopsies to evaluate for relevant molecular signatures.

Current developer: Merck

MedKoo Code#: 201918
Name: MK-8033
CAS#: 1196681-38-5 Synonym: MK-8033; MK8033. MK 8033. IUPAC/Chemical name: 1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide
Chemical structure	Theoretical analysis
	Chemical Formula: C25H21N5O3S Exact Mass: 471.13651 Molecular Weight: 471.53094 Elemental Analysis: C, 63.68; H, 4.49; N, 14.85; O, 10.18; S, 6.80
Availability and price: This agent is not in stock, may be available through custom synthesis. To inquire quotation and lead time or to ask questions, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer big discount for orders of bulk quantities.

Information about this agent

References

1. Combinations VEGF(R) inhibitors and hepatocyte growth factor (c-met) inhibitors for the treatment of cancer By Burgess, Theresa L.; Coxon, Angela; Dussault, Isabelle; Kaplan-Lefko, Paula; Polverino, Anthony J.; Beaupre, Darrin From PCT Int. Appl. (2009), WO 2009140549 A1 20091119.

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