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MedKoo product information:
Description of Imisopasem manganese
(M40403): Imisopasem manganese
(formerly as know as M40403) is a stable non-peptidyl
mimetic of MnSOD that crosses cell membranes and is effective in
reducing experimental inflammation.
found that M40403 was effective in reducing TBI-induced
tissue destruction and had potential as a new radioprotective agent.
offer a novel therapeutic approach for the management of various
cardiovascular diseases where these radicals have been postulated to
play a role.
ActivBiotics Inc., Metaphore Pharmaceuticals, Inc..
MedKoo Code#: 201800
Name: Imisopasem manganese
Code name: M40403; M 40403; SC-72325; Imisopasem manganese
1. Manganese, dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7Hdibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-κN5,κN13,κN18,κN21,κN22]-,
MedKoo Code#: 201800
Name: Imisopasem manganese
Chemical Formula: C21H35Cl2MnN5
Molecular Weight: 483.38
Elemental Analysis: C, 52.18; H, 7.30; Cl,
14.67; Mn, 11.37; N, 14.49
Availability and price:
Imisopasem manganese is available through custom synthesis.
Lead time 6- 8 weeks, please email to
ask for price if you are interested in.
To inquire quotation and lead time or to ask questions, please send email to
email@example.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
Information about this agent
M-40403 is a superoxide dismutase mimetic, which is
being evaluated for the potential treatment of pain,
dermatological disease, inflammation, as well as the treatment for the
side effects associated with chemotherapy and radiation therapy.
(source: IDrugs. 2005 Jan;8(1):67-76.)
This investigational small molecule mimics the action
of a natural component of the cells, an enzyme called superoxide
dismutase. Superoxide dismutase is thought to have a double
pharmacologic effect during the early stages of tissue damage, first
through the reduction of inflammation, and secondarily through the
decreased rate of programmed cell death (apoptosis). As mucositis
involves inflammation, the positive effect of the M40403 over this
process is expected to have a beneficial effect in the condition. M40403
has shown efficacy in an animal model where oral mucositis was induced
by acute irradiation. The compound has been evaluated in approximately
700 subjects in several Phase I and II clinical trials, and was shown to
be safe and well-tolerated.
1: Thompson JS, Chu Y, Glass J, Tapp AA, Brown SA.
The manganese superoxide dismutase mimetic, M40403, protects adult mice
from lethal total body irradiation. Free Radic Res. 2010
May;44(5):529-40. PubMed PMID: 20298121.
2: Murphy CK, Fey EG, Watkins BA, Wong V, Rothstein D, Sonis ST.
Efficacy of superoxide dismutase mimetic M40403 in attenuating
radiation-induced oral mucositis in hamsters. Clin Cancer Res. 2008 Jul
1;14(13):4292-7. PubMed PMID: 18594012.
3: Cuzzocrea S, Mazzon E, Paola RD, Genovese T, Muią C, Caputi AP,
Salvemini D. Effects of combination M40403 and dexamethasone therapy on
joint disease in a rat model of collagen-induced arthritis. Arthritis
Rheum. 2005 Jun;52(6):1929-40. PubMed PMID: 15934059.
4: Di Paola R, Mazzon E, Rotondo F, Dattola F, Britti D, De Majo M,
Genovese T, Cuzzocrea S. Reduced development of experimental
periodontitis by treatment with M40403, a superoxide dismutase mimetic.
Eur J Pharmacol. 2005 Jun 1;516(2):151-7. PubMed PMID: 15921679.
5: Nicotera TM, Ding D, McFadden SL, Salvemini D, Salvi R. Paraquat-induced
hair cell damage and protection with the superoxide dismutase mimetic
m40403. Audiol Neurootol. 2004 Nov-Dec;9(6):353-62. Epub 2004 Oct 1.
PubMed PMID: 15467288.
6: Di Filippo C, Cuzzocrea S, Marfella R, Fabbroni V, Scollo G, Berrino
L, Giugliano D, Rossi F, D'Amico M. M40403 prevents myocardial injury
induced by acute hyperglycaemia in perfused rat heart. Eur J Pharmacol.
2004 Aug 16;497(1):65-74. PubMed PMID: 15321736.
7: Jiang F, Guo Y, Salvemini D, Dusting GJ. Superoxide dismutase mimetic
M40403 improves endothelial function in apolipoprotein(E)-deficient
mice. Br J Pharmacol. 2003 Jul;139(6):1127-34. PubMed PMID: 12871831;
PubMed Central PMCID: PMC1573947.
8: Marzocca C, Vannacci A, Cuzzocrea S, Salvemini D, Mannaioni PF,
Masini E. Effects of the SOD mimetic, M40403, on prostaglandin
production in an in vivo model of ischemia and reperfusion in rat heart.
Inflamm Res. 2003 Apr;52 Suppl 1:S23-4. PubMed PMID: 12755394.
9: Samlowski WE, Petersen R, Cuzzocrea S, Macarthur H, Burton D,
McGregor JR, Salvemini D. A nonpeptidyl mimic of superoxide dismutase,
M40403, inhibits dose-limiting hypotension associated with interleukin-2
and increases its antitumor effects. Nat Med. 2003 Jun;9(6):750-5. Epub
2003 May 5. PubMed PMID: 12730689.
10: McFadden SL, Ding D, Salvemini D, Salvi RJ. M40403, a superoxide
dismutase mimetic, protects cochlear hair cells from gentamicin, but not
cisplatin toxicity. Toxicol Appl Pharmacol. 2003 Jan 1;186(1):46-54.
PubMed PMID: 12583992.
11: Wang C, McInnis J, West JB, Bao J, Anastasio N, Guidry JA, Ye Y,
Salvemini D, Johnson KM. Blockade of phencyclidine-induced cortical
apoptosis and deficits in prepulse inhibition by M40403, a superoxide
dismutase mimetic. J Pharmacol Exp Ther. 2003 Jan;304(1):266-71. PubMed
12: Masini E, Cuzzocrea S, Mazzon E, Marzocca C, Mannaioni PF, Salvemini
D. Protective effects of M40403, a selective superoxide dismutase
mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J
Pharmacol. 2002 Jul;136(6):905-17. Erratum in: Br J Pharmacol. 2002
Dec;137(8):1387. PubMed PMID: 12110615; PubMed Central PMCID:
13: Salvemini D, Mazzon E, Dugo L, Serraino I, De Sarro A, Caputi AP,
Cuzzocrea S. Amelioration of joint disease in a rat model of
collagen-induced arthritis by M40403, a superoxide dismutase mimetic.
Arthritis Rheum. 2001 Dec;44(12):2909-21. PubMed PMID: 11762952.
14: Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Riley DP, Salvemini D.
Protective effects of M40403, a superoxide dismutase mimetic, in a
rodent model of colitis. Eur J Pharmacol. 2001 Nov 30;432(1):79-89.
PubMed PMID: 11734191.
15: Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Lund DD, Salvemini D,
Yorek MA. Effect of M40403 treatment of diabetic rats on endoneurial
blood flow, motor nerve conduction velocity and vascular function of
epineurial arterioles of the sciatic nerve. Br J Pharmacol. 2001
Sep;134(1):21-9. PubMed PMID: 11522593; PubMed Central PMCID:
16: Salvemini D, Mazzon E, Dugo L, Riley DP, Serraino I, Caputi AP,
Cuzzocrea S. Pharmacological manipulation of the inflammatory cascade by
the superoxide dismutase mimetic, M40403. Br J Pharmacol. 2001
Feb;132(4):815-27. PubMed PMID: 11181422; PubMed Central PMCID:
(Keyword; CAS#; MedKoo code#)