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MedKoo product information:

 

 Kevetrin  

     

Description of  Kevetrin:   Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

 

Current developer: Cellceutix / Formatech

 

MedKoo Cat#: 205891

Name:  Kevetrin HCl

CAS#:  66592-89-0 (Kevetrin HCl); 500863-50-3 (Kevetrin)

Synonym: Kevetrin; thioureidobutyronitrile; thioureido butyronitrile

IUPAC/Chemical name: 

3-cyanopropyl carbamimidothioate hydrochloride 

Chemical structure

Theoretical analysis

 

Kevetrin structure

 

MedKoo Cat#: 205891
Name: Kevetrin HCl
CAS#: 66592-89-0

Chemical Formula: C5H10ClN3S
Molecular Weight: 179.67
Elemental Analysis: C, 33.42; H, 5.61; Cl, 19.73; N, 23.39; S, 17.85.

Kevetrin (free base)
Chemical Formula: C5H9N3S
Exact Mass: 143.05172, Molecular Weight: 143.21
Elemental Analysis: C, 41.93; H, 6.33; N, 29.34; S, 22.39

  

Availability and price:

Kevetrin HCl (99%) is in stock. Price reduced on 03/26/2014. Same day ship out. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping feefrom $30.00 (USA); from $45.00 (Canada); from $70.00 (international).

10 mg /  $90.00

25 mg / $150.00

50 mg / $250.00

100 mg / $350.00

200 mg / $450.00

500 mg / $550.00

1.0 g / $750.00

2.0 g / $1,250.00

5.0g / please ask price

Bulk quantities in stock at low price.

 

 

Technical data

Product data sheet

View product data sheet

Appearance:

white solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

View current batch of CoA

QC data:

View NMR, View HPLC, View MS

Safety Data Sheet (MSDS):

View Material Safety Data Sheet (MSDS)

Shipping condition:

Shipped under ambient temperature as non-hazardous chemical.  This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf life:

>2 years if stored properly

Note: The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

 

Protocols from literature

Drug formulation:

This drug may be formulated in DMSO

Stock solution storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

In vitro protocol:

 

In vivo protocol:

 

 

 

Highlights of recent research using this agent

Kevetrin is currently being developed by Cellceutix, who reported a recent study on Kevetrin™. The results show that Kevetrin has potent antitumor activity in several wild type and mutant p53 human tumor xenografts e.g. A549, PC-3, MDA-MB-231, HT-29, NCI-H1975, HCT-15, K-562, LNCaP. Kevetrin is non-genotoxic. DNA damaging drugs result in rapid phosphorylation of H2A.X at Ser 139 by PI3K-like kinases; however, Kevetrin did not induce phosphorylation of H2A.X. Since Kevetrin was well-tolerated in GLP safety pharmacology and toxicity studies. (source: http://cancerres.aacrjournals.org/cgi/content/short/72/8_MeetingAbstracts/2874?rss=1).

 

 

References

 1. Nitrile derivatives and their pharmaceutical use and compositions By Menon, Krishna
From U.S. Pat. Appl. Publ. (2012), US 20120189537 A1 20120726.

2. Nitrile derivatives and their pharmaceutical use and compositions By Menon, Krishna
From PCT Int. Appl. (2010), WO 2010135170 A2 20101125.

3. Preparation of 4-isothioureido butyronitrile hydrochloride derivatives for treatment of cancer By He, Lan; Pan, Xuan From Faming Zhuanli Shenqing (2009), CN 101550098 A 20091007.

4. Preparation of protein conjugates via intermolecular disulfide bond formation By King, Te Piao; Li, Yen; Kochoumian, Loucia From Biochemistry (1978), 17(8), 1499-506.

5. Preparation of some amino sulfonamides By Miller, Ellis; Sprague, James M.; Kissinger, L. W.; McBurney, Lane F. From Journal of the American Chemical Society (1940), 62, 2099-102.

 

 

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Fax: 919-980-4831
Email: sales@medkoo.com

 

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