HE-3235 - MedKoo Biosciences

Back to products

Browse products

Approved anticancer agents

Anticancer agents in trials

Anticancer agents in preclinical trials

Anticancer molecular libraries

Other drug agents

Drug intermediates

Bio-reagents and biochemicals

MedKoo product information:

HE-3235

MedKoo Code#: 205485
Name: HE-3235
CAS#: 183387-50-0 Synonym: Code name: HE-3235; Brand name: APOTONE, Chemical structure: 17alpha-ethynyl-5alpha-androstane-3alpha, 17beta-diol 　 IUPAC/Chemical name: (3R,5S,8R,9S,10S,13S,14S,17R)-17-ethynyl-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
Chemical structure	Theoretical analysis
	MedKoo Code#: 205485 Name: HE-3235 CAS#: 183387-50-0 Chemical Formula: C21H32O2 Exact Mass: 316.24023 Molecular Weight: 316.47758 Elemental Analysis: C, 79.70; H, 10.19; O, 10.11
Availability and price: This agent is not in stock, may be available through custom synthesis. To inquire quotation and lead time or to ask questions, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer big discount for orders of bulk quantities.

Information about this agent

HE3235 is an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Current developer: Harbor Biosciences.

References

1: Koreckij TD, Trauger RJ, Montgomery RB, Pitts TE, Coleman I, Nguyen H, Reading CL, Nelson PS, Vessella RL, Corey E. HE3235 inhibits growth of castration-resistant prostate cancer. Neoplasia. 2009 Nov;11(11):1216-25. PubMed PMID: 19881957; PubMed Central PMCID: PMC2767223.

2: Trauger R, Corey E, Bell D, White S, Garsd A, Stickney D, Reading C, Frincke J. Inhibition of androstenediol-dependent LNCaP tumour growth by 17alpha-ethynyl-5alpha-androstane-3alpha, 17beta-diol (HE3235). Br J Cancer. 2009 Apr 7;100(7):1068-72. PubMed PMID: 19337256; PubMed Central PMCID: PMC2669987.

Contact MedKoo:

Email: sales@medkoo.com

(Keyword; CAS#; MedKoo code#)