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CP-724714

Description of CP-724714: CP-724714 is An orally bioavailable quinazoline with potential antineoplastic activity. CP-724,714 selectively binds to the intracellular domain of HER2, reversibly inhibiting its tyrosine kinase activity and resulting in suppression of tumor cell growth. HER2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in many adenocarcinomas, particularly breast cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Current developer: OSI Pharmaceuticals  and Pfizer

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17. Guo, Feng; Letrent, Stephen P.; Munster, Pamela N.; Britten, Carolyn D.; Gelmon, Karen; Tolcher, Anthony W.; Sharma, Amarnath. Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety. Cancer Chemotherapy and Pharmacology (2008), 62(1), 97-109. CODEN: CCPHDZ ISSN:0344-5704. CAN 150:182659 AN 2008:466826

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