CLR-1404 - MedKoo Biosciences

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MedKoo product information:

CLR-1404

MedKoo Code#: 204940
Name: CLR-1404
CAS#: Synonym: I-131-CLR1404. Abbreviation: I-131 PLE analogue CLR1404 　 IUPAC/Chemical name:
Chemical structure	Theoretical analysis

Availability and price: This agent is not available, may be through custom synthesis. To inquire quotation and lead time or to ask questions, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer big discount for orders of bulk quantities.

Information about this agent

CLR1404 is a small-molecule radiopharmaceutical consisting of the beta-emitting radioisotope iodine I 131 attached to a phospholipid ether (PLE) analogue, comprised of a linear 18 carbon backbone, with potential antineoplastic activity. Iodine I 131 phospholipid ether analogue CLR1404 selectively accumulates in tumor cells, thereby delivering a cytotoxic dose of radiation to cancer cells. Compared to normal cells, tumor cells are unable to metabolize and eliminate PLEs possibly due to deficiency of the enzyme phospholipase-D. In addition, the radioiodine moiety of this agent is resistant to de-iodination. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Current developer: Cellectar.

References

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