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MedKoo product information:
CJ-15161
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MedKoo Code#:
200781
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Name:
CJ-15161
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CAS#:
204970-97-8
Synonym: CJ-15161; CJ-15,161;
Benzamide,
4-[[(1S)-2-[(3S)-3-hydroxy-1-pyrrolidinyl]-1-phenylethyl]methylamino]-N-propyl-
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IUPAC/Chemical name:
4-(((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylethyl)(methyl)amino)-N-propylbenzamide
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Chemical structure: |
Theoretical analysis
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Chemical Formula: C23H31N3O2
Exact Mass: 381.24163
Molecular Weight: 381.51114 m/z: 381.24163
(100.0%), 382.24498 (24.9%), 383.24834 (3.0%), 382.23866 (1.1%)
Elemental Analysis: C, 72.41; H, 8.19; N,
11.01; O, 8.39
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Availability and price:
This agent is not in stock, which may be available through custom synthesis. To inquire quotation and lead time or to ask questions, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
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Quality control
data:
Product will be shipped with
supporting analytical data.
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Information about this agent
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CJ-15,161 is a κ-opioid receptor agonist.
Current developer: Pfizer
1. Ito, Fumitaka; Kondo, Hiroshi. Process for
producing pyrrolidinyl- and pyrrolinylethylamine compounds as kappa
agonists and pharmaceutical compositions containing them. Hung. Pat.
Appl. (2000), 160 pp. CODEN: HUXXCV HU 9903452 A2 20000228 CAN 147:72632
AN 2007:370172 CAPLUS
2. Andresen, Brian M.; Caron, Stephane; Couturier, Michel; DeVries,
Keith M.; Do, Nga M.; Dupont-Gaudet, Kristina; Ghosh, Arun; Girardin,
Melina; Hawkins, Joel M.; Makowski, Teresa M.; Riou, Maxime; Sieser,
Janice E.; Tucker, John L.; Vanderplas, Brian C.; Watson, Timothy J. N.
Process research and scale-up of the -opioid receptor agonist
CJ-15,161 drug candidate. Chimia (2006), 60(9), 554-560. CODEN: CHIMAD
ISSN:0009-4293. CAN 147:257605 AN 2006:1141127 CAPLUS
3. Ghosh, Arun; Sieser, Janice E.; Caron, Stephane; Couturier, Michel;
Dupont-Gaudet, Kristina; Girardin, Melina. Cu-Catalyzed N-Arylation of
Oxazolidinones: An Efficient Synthesis of the -Opioid Receptor Agonist
CJ-15161. Journal of Organic Chemistry (2006), 71(3), 1258-1261. CODEN:
JOCEAH ISSN:0022-3263. CAN 144:232953 AN 2006:18454 CAPLUS
4. Couturier, Michel; Tucker, John L.; Andresen, Brian M.; DeVries,
Keith M.; Vanderplas, Brian C.; Ito, Fumitaka. Efficient synthesis of
the -opioid receptor agonist CJ-15,161: four stereospecific inversions
at a single aziridinium stereogenic center. Tetrahedron: Asymmetry
(2003), 14(22), 3517-3523. CODEN: TASYE3 ISSN:0957-4166. CAN 140:111217
AN 2003:877272 CAPLUS
5. Quallich, George Joseph; Castaldi, Michael James. Preparation of
crystalline anhydrous and monohydrate benzoate salts of
(2'S,3S)-3-hydroxy-N-[2-[N-methyl-N-4-[(N-propylamino)carbonyl]phenyl]amino-2-phenyl]ethylpyrrolidine
as -opioid receptor agonists. PCT Int. Appl. (2003), 16 pp. CODEN:
PIXXD2 WO 2003072544 A1 20030904 CAN 139:230618 AN 2003:696867 CAPLUS
6. Devries, Keith M.; Couturier, Michel A.; Andresen, Brian M.; Tucker,
John L.; Ito, Fumitaka. Preparation of hydroxypyrrolidinyl ethylamine
compounds useful as selective -opioid receptor agonists. U.S. Pat.
Appl. Publ. (2002), 13 pp. CODEN: USXXCO US 2002161241 A1 20021031 CAN
137:337777 AN 2002:833565 CAPLUS
7. Ghosh, Arun; Sieser, Janice E.; Caron, Stephane; Watson, Timothy J.
N. Synthesis of the kappa-agonist CJ-15,161 via a palladium-catalyzed
cross-coupling reaction. Chemical Communications (Cambridge, United
Kingdom) (2002), (15), 1644-1645. CODEN: CHCOFS ISSN:1359-7345. CAN
138:73134 AN 2002:517323 CAPLUS
8. Ito, Fumitaka; Kondo, Hiroshi. Preparation of pyrrolidinyl- and
pyrrolinylethylarylamines as kappa opioid receptor agonists. U.S.
(2001), 39 pp., Cont.-in-part of Appl. No. PCT/IB96/00957. CODEN: USXXAM
US 6201007 B1 20010313 CAN 134:222619 AN 2001:178439 CAPLUS
9. Ito, Fumitaka; Kondo, Hiroshi. Preparation of pyrrolidinyl- and
pyrrolinylethylamines as kappa agonists. PCT Int. Appl. (1998), 129 pp.
CODEN: PIXXD2 WO 9812177 A1 19980326 CAN 128:243949 AN 1998:199673
CAPLUS
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