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MedKoo product information:
Bevonium methylsulfate
Description of Bevonium methylsulfate: Bevonium methylsulfate
(CG-201), currently being developed by CG Therapeutics,
Inc. is an injection that stimulates antibodies to block the
pathological forms of hCG that help cancer cells grow and evade the
immune system. . According to CG Therapeutics's website, CG201 was
originally created in collaboration with the World Health Organization
as a low-cost contraceptive method for developing countries. CG201 is
now approved for a Phase I clinical trial in Sweden. A single injection
can protect against pregnancy for up to one year, and protection is
reversible after that. (source:
http://www.cgtherapeutics.com/).
Current developer:
CG Therapeutics
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MedKoo Code#: 204920
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Name: Bevonium methylsulfate
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CAS#: 5205-82-3
Synonym:
CG-201, Bevonium methylsulfate. Other names:
(1) . Piperidinium,
2-[[(2-hydroxy-2,2-diphenylacetyl)oxy]methyl]-1,1-dimethyl-,
methyl sulfate (1:1). (2).
Piperidinium, 2-(hydroxymethyl)-1,1-dimethyl-, methyl sulfate,
benzilate (8CI). (3).
Piperidinium, 2-[[(hydroxydiphenylacetyl)oxy]methyl]-1,1-dimethyl-,
methyl sulfate (salt) (9CI). (4).
Benzilic acid, ester with 2-(hydroxymethyl)-1,1-dimethylpiperidinium
methyl sulfate (8CI); (5). Acabel;
(6) N,N-Dimethyl-2-(hydroxymethyl)piperidinium benzilate methyl
sulfate. (7). Piribenzil methosulfate. (8) Piribenzil
methyl sulfate.
IUPAC/Chemical name:
2-((2-hydroxy-2,2-diphenylacetoxy)methyl)-1,1-dimethylpiperidin-1-ium
methyl sulfate.
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Chemical structure
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Theoretical analysis
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MedKoo Code#: 204920
Name: Bevonium methylsulfate
CAS#: 5205-82-3.
Chemical Formula: C23H31NO7S
Molecular Weight: 465.56
Elemental Analysis: C, 59.34; H, 6.71; N,
3.01; O, 24.06; S, 6.89
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Availability and price:
This agent is
not available, may be through custom synthesis.
To inquire quotation and lead time or to ask questions, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer big discount for orders of bulk quantities.
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Information about this agent
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1: Stall L, Lee J, McCullough M, Nsrouli-Maktabi H,
Spies JB. Effectiveness of elective unilateral uterine artery
embolization: a case-control study. J Vasc Interv Radiol. 2011
May;22(5):716-22. PubMed PMID: 21514525.
2: Hu NN, Kaw D, McCullough MF, Nsouli-Maktabi H, Spies JB. Menopause
and menopausal symptoms after ovarian artery embolization: a comparison
with uterine artery embolization controls. J Vasc Interv Radiol. 2011
May;22(5):710-715.e1. PubMed PMID: 21514524.
3: Costantino M, Lee J, McCullough M, Nsouli-Maktabi H, Spies JB.
Bilateral versus unilateral femoral access for uterine artery
embolization: results of a randomized comparative trial. J Vasc Interv
Radiol. 2010 Jun;21(6):829-35; quiz 835. Epub 2010 Apr 15. Erratum in: J
Vasc Interv Radiol. 2010 Nov;21(11):1786. Nsrouli-Maktabi, Hala
[corrected to Nsouli-Maktabi, Hala]. PubMed PMID: 20399113.
4: Banovac F, Cheng P, Campos-Nanez E, Kallakury B, Popa T, Wilson E,
Abeledo H, Cleary K. Radiofrequency ablation of lung tumors in swine
assisted by a navigation device with preprocedural volumetric planning.
J Vasc Interv Radiol. 2010 Jan;21(1):122-9. Epub 2009 Nov 25. PubMed
PMID: 19939704; PubMed Central PMCID: PMC2818540.
5: Meyer J, Nsouli-Maktabi H, Spies JB. Quality of interventional
radiology literature: a review of articles published in JVIR and CVIR. J
Vasc Interv Radiol. 2009 Oct;20(10):1271-6. Epub 2009 Jul 23. Review.
PubMed PMID: 19631559.
6: White AM, Banovac F, Yousefi S, Slack RS, Spies JB. Uterine fibroid
embolization: the utility of aortography in detecting ovarian artery
collateral supply. Radiology. 2007 Jul;244(1):291-8. PubMed PMID:
17581907.
7: White AM, Banovac F, Spies JB. Patient radiation exposure during
uterine fibroid embolization and the dose attributable to aortography. J
Vasc Interv Radiol. 2007 Apr;18(4):573-6. PubMed PMID: 17446550.
8: Spies JB, Cornell C, Worthington-Kirsch R, Lipman JC, Benenati JF.
Long-term outcome from uterine fibroid embolization with tris-acryl
gelatin microspheres: results of a multicenter study. J Vasc Interv
Radiol. 2007 Feb;18(2):203-7. PubMed PMID: 17327552.
9: Yousefi S, Czeyda-Pommersheim F, White AM, Banovac F, Hahn WY, Spies
JB. Repeat uterine artery embolization: indications and technical
findings. J Vasc Interv Radiol. 2006 Dec;17(12):1923-9. PubMed PMID:
17185687.
10: Spies JB. Adding to our understanding of uterine fibroid
embolization. AJR Am J Roentgenol. 2006 Mar;186(3):846-7. PubMed PMID:
16498119.
11: Spies JB, Allison S, Flick P, Cramp M, Bruno J, Jha RC, Ascher SA.
Spherical polyvinyl alcohol versus tris-acryl gelatin microspheres for
uterine artery embolization for leiomyomas: results of a limited
randomized comparative study. J Vasc Interv Radiol. 2005
Nov;16(11):1431-7. PubMed PMID: 16319148.
12: He M, Yang YX, Han H, Men JH, Bian LH, Wang GD. Effects of yogurt
supplementation on the growth of preschool children in Beijing suburbs.
Biomed Environ Sci. 2005 Jun;18(3):192-7. PubMed PMID: 16131023.
13: Pelage JP, Guaou NG, Jha RC, Ascher SM, Spies JB. Uterine fibroid
tumors: long-term MR imaging outcome after embolization. Radiology. 2004
Mar;230(3):803-9. PubMed PMID: 14990844.
14: Baker CM, Winkel CA, Subramanian S, Spies JB. Estimated costs for
uterine artery embolization and abdominal myomectomy for uterine
leiomyomata: a comparative study at a single institution. J Vasc Interv
Radiol. 2002 Dec;13(12):1207-10. PubMed PMID: 12471183.
15: Saraiya PV, Chang TC, Pelage JP, Spies JB. Uterine artery
replacement by the round ligament artery: an anatomic variant discovered
during uterine artery embolization for leiomyomata. J Vasc Interv Radiol.
2002 Sep;13(9 Pt 1):939-41. PubMed PMID: 12354830.
16: Sonntag WE, Forman LJ, Miki N, Steger RW, Ramos T, Arimura A, Meites
J. Effects of CNS active drugs and somatostatin antiserum on growth
hormone release in young and old male rats. Neuroendocrinology. 1981
Aug;33(2):73-8. PubMed PMID: 6115331.
17: Barbezat GO, Bank S. Letter: A double-blind trial of bevonium
methylsulphate on gastric acid secretion in man. S Afr Med J. 1976 Jan
3;50(1):4. PubMed PMID: 766231.
18: Hasegawa T, Ando Y. [Bevonium methylsulfate (CG 201) in the
treatment of enuresis and bladder neurosis]. Hinyokika Kiyo. 1970
Jul;16(7):362-5. Japanese. PubMed PMID: 5465265.
19: Tomoyoshi T, Harada T. [Clinical use of CG-201 (Acabel), a new
spasmolytic, in urology]. Hinyokika Kiyo. 1968 Nov;14(11):845-7.
Japanese. PubMed PMID: 5752068.
20: Oka N, Ito H. [Effect of piribenzil methylsulfate (CG-201) on
ureteral activity]. Hinyokika Kiyo. 1968 Nov;14(11):833-44. Japanese.
PubMed PMID: 5752067.
21: Ishigami J, Hara S, Shiba T. [CG-201, a new antispasmodic, in
urological practice]. Hinyokika Kiyo. 1968 Sep;14(9):691-3. Japanese.
PubMed PMID: 5751194.
22: Murata M, Ohashi H. [The effect of Acabel (CG-201) on ureteral
movement and its clinical use for pain due to renal ptosis]. Hinyokika
Kiyo. 1968 Aug;14(8):594-9. Japanese. PubMed PMID: 5750161.
23: Ishibe T, Shimada T, Mizoguchi M. [Use of a new anti-colic
analgesic, "Compound CG-201", in urology]. Hinyokika Kiyo. 1968
May;14(5):533-9. Japanese. PubMed PMID: 5750153.
24: Longin F. [Pharmacoradiographic studies of the esophagogastric
junction area to demonstrate presence of a small hiatus hernia. (Current
results of the testing of CG 201 Gruenenthal)]. Fortschr Geb Rontgenstr
Nuklearmed. 1966 Mar;104(3):389-98. German. PubMed PMID: 6010848.
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