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MedKoo product information:

 

Bevonium methylsulfate 

 

Description of Bevonium methylsulfate: Bevonium methylsulfate (CG-201), currently being developed by CG Therapeutics, Inc. is an injection that stimulates antibodies to block the pathological forms of hCG that help cancer cells grow and evade the immune system. . According to CG Therapeutics's website, CG201 was originally created in collaboration with the World Health Organization as a low-cost contraceptive method for developing countries. CG201 is now approved for a Phase I clinical trial in Sweden. A single injection can protect against pregnancy for up to one year, and protection is reversible after that. (source: http://www.cgtherapeutics.com/).

 

Current developer:    CG Therapeutics

  

MedKoo Code#:  204920

Name:  Bevonium methylsulfate

CAS#:  5205-82-3

  

Synonym:   CG-201, Bevonium methylsulfate. Other names:

(1) .   Piperidinium, 2-[[(2-hydroxy-2,2-diphenylacetyl)oxy]methyl]-1,1-dimethyl-, methyl sulfate (1:1).      (2).    Piperidinium, 2-(hydroxymethyl)-1,1-dimethyl-, methyl sulfate, benzilate (8CI).        (3).   Piperidinium, 2-[[(hydroxydiphenylacetyl)oxy]methyl]-1,1-dimethyl-, methyl sulfate (salt) (9CI).     (4). Benzilic acid, ester with 2-(hydroxymethyl)-1,1-dimethylpiperidinium methyl sulfate (8CI);     (5).  Acabel;     (6) N,N-Dimethyl-2-(hydroxymethyl)piperidinium benzilate methyl sulfate. (7). Piribenzil methosulfate.  (8) Piribenzil methyl sulfate.

  

IUPAC/Chemical name: 

2-((2-hydroxy-2,2-diphenylacetoxy)methyl)-1,1-dimethylpiperidin-1-ium methyl sulfate.

   

Chemical structure

Theoretical analysis

 

 

MedKoo Code#:  204920
Name:  Bevonium methylsulfate
CAS#:  5205-82-3.

Chemical Formula: C23H31NO7S

Molecular Weight: 465.56

Elemental Analysis: C, 59.34; H, 6.71; N, 3.01; O, 24.06; S, 6.89

 

Availability and price:

This agent is not available, may be  through  custom synthesis.

 

To inquire quotation and lead time or to ask questions, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer big discount for orders of bulk quantities.

 

 

Information about this agent

  

  

 

References

1: Stall L, Lee J, McCullough M, Nsrouli-Maktabi H, Spies JB. Effectiveness of elective unilateral uterine artery embolization: a case-control study. J Vasc Interv Radiol. 2011 May;22(5):716-22. PubMed PMID: 21514525.

2: Hu NN, Kaw D, McCullough MF, Nsouli-Maktabi H, Spies JB. Menopause and menopausal symptoms after ovarian artery embolization: a comparison with uterine artery embolization controls. J Vasc Interv Radiol. 2011 May;22(5):710-715.e1. PubMed PMID: 21514524.

3: Costantino M, Lee J, McCullough M, Nsouli-Maktabi H, Spies JB. Bilateral versus unilateral femoral access for uterine artery embolization: results of a randomized comparative trial. J Vasc Interv Radiol. 2010 Jun;21(6):829-35; quiz 835. Epub 2010 Apr 15. Erratum in: J Vasc Interv Radiol. 2010 Nov;21(11):1786. Nsrouli-Maktabi, Hala [corrected to Nsouli-Maktabi, Hala]. PubMed PMID: 20399113.

4: Banovac F, Cheng P, Campos-Nanez E, Kallakury B, Popa T, Wilson E, Abeledo H, Cleary K. Radiofrequency ablation of lung tumors in swine assisted by a navigation device with preprocedural volumetric planning. J Vasc Interv Radiol. 2010 Jan;21(1):122-9. Epub 2009 Nov 25. PubMed PMID: 19939704; PubMed Central PMCID: PMC2818540.

5: Meyer J, Nsouli-Maktabi H, Spies JB. Quality of interventional radiology literature: a review of articles published in JVIR and CVIR. J Vasc Interv Radiol. 2009 Oct;20(10):1271-6. Epub 2009 Jul 23. Review. PubMed PMID: 19631559.

6: White AM, Banovac F, Yousefi S, Slack RS, Spies JB. Uterine fibroid embolization: the utility of aortography in detecting ovarian artery collateral supply. Radiology. 2007 Jul;244(1):291-8. PubMed PMID: 17581907.

7: White AM, Banovac F, Spies JB. Patient radiation exposure during uterine fibroid embolization and the dose attributable to aortography. J Vasc Interv Radiol. 2007 Apr;18(4):573-6. PubMed PMID: 17446550.

8: Spies JB, Cornell C, Worthington-Kirsch R, Lipman JC, Benenati JF. Long-term outcome from uterine fibroid embolization with tris-acryl gelatin microspheres: results of a multicenter study. J Vasc Interv Radiol. 2007 Feb;18(2):203-7. PubMed PMID: 17327552.

9: Yousefi S, Czeyda-Pommersheim F, White AM, Banovac F, Hahn WY, Spies JB. Repeat uterine artery embolization: indications and technical findings. J Vasc Interv Radiol. 2006 Dec;17(12):1923-9. PubMed PMID: 17185687.

10: Spies JB. Adding to our understanding of uterine fibroid embolization. AJR Am J Roentgenol. 2006 Mar;186(3):846-7. PubMed PMID: 16498119.

11: Spies JB, Allison S, Flick P, Cramp M, Bruno J, Jha RC, Ascher SA. Spherical polyvinyl alcohol versus tris-acryl gelatin microspheres for uterine artery embolization for leiomyomas: results of a limited randomized comparative study. J Vasc Interv Radiol. 2005 Nov;16(11):1431-7. PubMed PMID: 16319148.

12: He M, Yang YX, Han H, Men JH, Bian LH, Wang GD. Effects of yogurt supplementation on the growth of preschool children in Beijing suburbs. Biomed Environ Sci. 2005 Jun;18(3):192-7. PubMed PMID: 16131023.

13: Pelage JP, Guaou NG, Jha RC, Ascher SM, Spies JB. Uterine fibroid tumors: long-term MR imaging outcome after embolization. Radiology. 2004 Mar;230(3):803-9. PubMed PMID: 14990844.

14: Baker CM, Winkel CA, Subramanian S, Spies JB. Estimated costs for uterine artery embolization and abdominal myomectomy for uterine leiomyomata: a comparative study at a single institution. J Vasc Interv Radiol. 2002 Dec;13(12):1207-10. PubMed PMID: 12471183.

15: Saraiya PV, Chang TC, Pelage JP, Spies JB. Uterine artery replacement by the round ligament artery: an anatomic variant discovered during uterine artery embolization for leiomyomata. J Vasc Interv Radiol. 2002 Sep;13(9 Pt 1):939-41. PubMed PMID: 12354830.

16: Sonntag WE, Forman LJ, Miki N, Steger RW, Ramos T, Arimura A, Meites J. Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats. Neuroendocrinology. 1981 Aug;33(2):73-8. PubMed PMID: 6115331.

17: Barbezat GO, Bank S. Letter: A double-blind trial of bevonium methylsulphate on gastric acid secretion in man. S Afr Med J. 1976 Jan 3;50(1):4. PubMed PMID: 766231.

18: Hasegawa T, Ando Y. [Bevonium methylsulfate (CG 201) in the treatment of enuresis and bladder neurosis]. Hinyokika Kiyo. 1970 Jul;16(7):362-5. Japanese. PubMed PMID: 5465265.

19: Tomoyoshi T, Harada T. [Clinical use of CG-201 (Acabel), a new spasmolytic, in urology]. Hinyokika Kiyo. 1968 Nov;14(11):845-7. Japanese. PubMed PMID: 5752068.

20: Oka N, Ito H. [Effect of piribenzil methylsulfate (CG-201) on ureteral activity]. Hinyokika Kiyo. 1968 Nov;14(11):833-44. Japanese. PubMed PMID: 5752067.

21: Ishigami J, Hara S, Shiba T. [CG-201, a new antispasmodic, in urological practice]. Hinyokika Kiyo. 1968 Sep;14(9):691-3. Japanese. PubMed PMID: 5751194.

22: Murata M, Ohashi H. [The effect of Acabel (CG-201) on ureteral movement and its clinical use for pain due to renal ptosis]. Hinyokika Kiyo. 1968 Aug;14(8):594-9. Japanese. PubMed PMID: 5750161.

23: Ishibe T, Shimada T, Mizoguchi M. [Use of a new anti-colic analgesic, "Compound CG-201", in urology]. Hinyokika Kiyo. 1968 May;14(5):533-9. Japanese. PubMed PMID: 5750153.

24: Longin F. [Pharmacoradiographic studies of the esophagogastric junction area to demonstrate presence of a small hiatus hernia. (Current results of the testing of CG 201 Gruenenthal)]. Fortschr Geb Rontgenstr Nuklearmed. 1966 Mar;104(3):389-98. German. PubMed PMID: 6010848.


 

 

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