Drug name

CAS#

Chemical structure and possible mechanism

Note

O6-benzylguanine

O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair.   Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

For availability and  price, please send email to: sales@medkoo.com.

References:

Clin Cancer Res. 2005，11(21):7861-5

Carmustine

(BCNU, 1,3-bis(2-chloroethyl)-1-nitrosourea)

154-93-8

Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

For availability and  price, please send email to: sales@medkoo.com.

References:

Clin Cancer Res. 2005，11(21):7861-5

Mol Cancer Ther. 2003，2(10):1061-6.

O6-benzyl-8-oxoguanine

This compound  is a MGMT/AGT inhibitor with potential anticancer activity

For availability and  price, please send email to: sales@medkoo.com.

References:

Biochem Pharmacol. 1999，58(2):237-44.

Aminooxyacetic acid

This compound  is a MGMT/AGT inhibitor with potential anticancer activity

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References:

Clin Chim Acta. 1995，243(2):105-14.

O6-methyl-2'-deoxyguanosine

This compound  is a MGMT/AGT inhibitor with potential anticancer activity

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References:

Biokhimiia. 1995, 60(9):1521-9.