Vorinostat | CAS#149647-78-9

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MedKoo product information:

Vorinostat

Vorinostat is a synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs). This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependant kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

MedKoo Code#: 10094

Name: Vorinostat

CAS#: 149647-78-9

Synonym: suberoylanilide hydroxamic acid; US brand name: Zolinza; Abbreviation: SAHA; Code name: L-001079038.

IUPAC/Chemical name:

N1-hydroxy-N8-phenyloctanediamide.

Chemical structure

Theoretical analysis

MedKoo Code#: 10094
Name: Vorinostat
CAS#: 149647-78-9

Chemical Formula: C14H20N2O3

Exact Mass: 264.14739

Molecular Weight: 264.32020

Elemental Analysis: C, 63.62; H, 7.63; N, 10.60; O, 18.16

Availability and lead time

Vorinostat (SAHA, 99%) is in stock.

100mg / $250.00

500mg/$350.00

1g / $450.00

For quotation, question, and order, please send email to sales@medkoo.com to describe your needs. A representative will respond your email shortly. We offer significant discount for larger quantity order.

Quality control data:

Product will be shipped with supporting analytical data.

Information about this agent

References

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