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 Ranimustine

ranimustine is a chloroethylnitrosourea derivative that inhibits proliferation and growth of tumor cells by alkylation and cross-linkage of DNA strands of tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

 1: NAGAI Y, MORI M, INOUE D, KIMURA T, SHIMOJI S, TOGAMI K, TABATA S, MATSUSHITA A, NAGAI K, Imai Y, Takafuta T, Takahashi T. Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma. Rinsho Ketsueki. 2009 Nov;50(11):1641-6. PubMed PMID: 20009441.

2: Numata A, Miyamoto T, Ohno Y, Kamimura T, Kamezaki K, Tanimoto T, Takase K, Henzan H, Kato K, Takenaka K, Fukuda T, Harada N, Nagafuji K, Teshima T, Akashi K, Harada M, Eto T; Fukuoka Blood and Marrow Transplantation Group. Long-term outcomes of autologous PBSCT for peripheral T-cell lymphoma: retrospective analysis of the experience of the Fukuoka BMT group. Bone Marrow Transplant. 2010 Feb;45(2):311-6. Epub 2009 Jul 13. PubMed PMID: 19597416.

3: Hoshi M, Ito H, Fujigaki H, Takemura M, Takahashi T, Tomita E, Ohyama M, Tanaka R, Ohtaki H, Saito K, Seishima M. Changes in serum tryptophan catabolism as an indicator of disease activity in adult T-cell leukemia/lymphoma. Leuk Lymphoma. 2009 Aug;50(8):1372-4. PubMed PMID: 19544139.

4: Kubota Y, Waki M. [Long-term remission of non-Hodgkin lymphoma secondary to the treatment for essential thrombocythemia]. Rinsho Ketsueki. 2009 Mar;50(3):197-202. Japanese. PubMed PMID: 19352088.

5: Ohno M, Natsume A, Fujii M, Ito M, Wakabayashi T. Interferon-beta, MCNU, and conventional radiotherapy for pediatric patients with brainstem glioma. Pediatr Blood Cancer. 2009 Jul;53(1):37-41. PubMed PMID: 19260101.

6: Kawabata KC, Hagiwara S, Takenouchi A, Tanimura A, Tanuma J, Tachikawa N, Miwa A, Oka S. Autologous stem cell transplantation using MEAM regimen for relapsed AIDS-related lymphoma patients who received highly active anti-retroviral therapy: a report of three cases. Intern Med. 2009;48(2):111-4. Epub 2009 Jan 15. PubMed PMID: 19145056.

7: Watanabe S, Sato S, Nagase S, Ohkuma S. Chemotherapeutic choice of ranimustine or nimustine on the basis of regional polyamine levels in rat brain. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):115-20. PubMed PMID: 18560626.

8: Yoshimura J, Nishiyama K, Mori H, Takahashi H, Fujii Y. Intrathecal chemotherapy for refractory disseminated medulloblastoma. Childs Nerv Syst. 2008 May;24(5):581-5. Epub 2007 Dec 5. PubMed PMID: 18057943.

9: Tsukasaki K, Utsunomiya A, Fukuda H, Shibata T, Fukushima T, Takatsuka Y, Ikeda S, Masuda M, Nagoshi H, Ueda R, Tamura K, Sano M, Momita S, Yamaguchi K, Kawano F, Hanada S, Tobinai K, Shimoyama M, Hotta T, Tomonaga M; Japan Clinical Oncology Group Study JCOG9801. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol. 2007 Dec 1;25(34):5458-64. Epub 2007 Oct 29. PubMed PMID: 17968021.

10: Murakami H, Yamane A, Sawamura M, Matsumoto M, Murayaman K, Shimano S, Jinbo T, Yokohama A, Uchiumi H, Handa H, Matsushima T, Tsukamoto N, Morita K, Karasawa M, Ogawara H, Nojima Y. Combination chemotherapy of ranimustine, doxorubicine, and dexamethasone for relapsing multiple myeloma--a pilot study. J Med. 2003;34(1-6):39-46. PubMed PMID: 17682310.

11: Ito M, Wakabayashi T, Natsume A, Hatano H, Fujii M, Yoshida J. Genetically heterogeneous glioblastoma recurring with disappearance of 1p/19q losses: case report. Neurosurgery. 2007 Jul;61(1):E168-9; discussion E169. PubMed PMID: 17621007.

12: Natori K, Izumi H, Kaneko K, Ishihara S, Nagase D, Fujimoto Y, Kato M, Umeda M, Kuraishi Y. [Four cases of therapy-related leukemia in multiple myeloma]. Gan To Kagaku Ryoho. 2007 Jan;34(1):121-4. Japanese. PubMed PMID: 17220686.

13: Oshiro S, Tsugu H, Komatsu F, Ohnishi H, Ueno Y, Sakamoto S, Fukushima T, Soma G. Evaluation of intratumoral administration of tumor necrosis factor-alpha in patients with malignant glioma. Anticancer Res. 2006 Nov-Dec;26(6A):4027-32. PubMed PMID: 17195453.

14: Tanaka Y, Nagai Y, Mori M, Fujita H, Togami K, Kurata M, Matsushita A, Maeda A, Nagai K, Tanaka K, Takahashi T. Multiple granulocytic sarcomas in essential thrombocythemia. Int J Hematol. 2006 Dec;84(5):413-6. PubMed PMID: 17189221.

15: Handa H, Irisawa H, Komatsumoto S, Matsushima T, Tsukamoto N, Nojima Y, Murakami H. [Plasmacytoma with multiple hypervascular lesions revealed by angiography in a patient with multiple myeloma]. Rinsho Ketsueki. 2006 Jun;47(6):521-5. Japanese. PubMed PMID: 16862980.

16: Wakabayashi T, Natsume A, Yoshida J. [Glioma]. Nippon Rinsho. 2006 Jul;64(7):1327-32. Review. Japanese. PubMed PMID: 16838652.

17: Tamiya T, Takao S, Ichikawa T, Chayama K, Date I. Successful chemotherapy for congenital malignant gliomas: a report of two cases. Pediatr Neurosurg. 2006;42(4):240-4. PubMed PMID: 16714866.

18: Nagasaki A, Taira N, Tomoyose T, Miyagi T, Nakachi S, Shinzato O, Hasegawa H, Takasu N. [Development of acute type, CD 8 positive adult T-cell leukemia in a carrier of hepatitis B virus--possible therapeutic effect of lamivudine combined with chemotherapy]. Gan To Kagaku Ryoho. 2006 May;33(5):683-6. Japanese. PubMed PMID: 16685173.

19: Yutaka H, Mariko Y, Shinichiro O, Kunihiko M, Yusuke T, Yasuo I. Thalidomide for the treatment of leptomeningeal multiple myeloma. Eur J Haematol. 2006 Apr;76(4):358-9. PubMed PMID: 16519710.

20: Motomura S, Hashimoto C, Kodama F, Maruta A, Sakai R, Fujita H, Tomita N, Fujisawa S, Harano H, Koharazawa H, Fujimaki K, Kanamori H, Ishigatsubo Y. [Trial of front-line intensive chemotherapy followed by peripheral blood stem cell transplantation in high-intermediate and high risk non-Hodgkin's lymphoma patients]. Rinsho Ketsueki. 2005 May;46(5):350-7. Japanese. PubMed PMID: 16444968.

21: Ikeda H, Hayashi T, Nojima M, Yasui H, Ikeda Y, Ishida T, Adachi M, Imai K. [Effective combination therapy of bortezomib and dexamethasone for two patients with refractory multiple myeloma]. Rinsho Ketsueki. 2005 Apr;46(4):269-73. Japanese. PubMed PMID: 16444959.

22: Hirose A, Yamane T, Nakajima Y, Manabe M, Kanashima H, Hagihara K, Sakamoto E, Nakamae M, Terada Y, Kosaka S, Aoyama Y, Sakamoto C, Kumura T, Koh KR, Hirai M, Ohta K, Nakao Y, Mugitani A, Teshima H, Hino M. [Autologous hematopoietic stem cell transplantation for aggressive B-cell non-Hodgkin's lymphoma]. Gan To Kagaku Ryoho. 2005 Dec;32(13):2059-64. Japanese. PubMed PMID: 16352929.

23: Yamamoto M, Iwaasa M, Nonaka M, Tsugu H, Nabeshima K, Fukushima T. Efficacy and feasibility of procarbazine, ranimustine and vincristine chemotherapy, and the role of surgical resection in anaplastic oligodendroglioma. Anticancer Res. 2005 Nov-Dec;25(6A):3715-23. PubMed PMID: 16302731.

24: Iyoda M, Ito J, Ajiro Y, Nagai H, Uchida J, Honda H, Kuroki A, Shibata T, Kitazawa K, Sugisaki T. [Focal segmental glomerulosclerosis in a patient with polycythemia vera]. Nippon Jinzo Gakkai Shi. 2005;47(7):828-33. Japanese. PubMed PMID: 16296413.

25: Shingu T, Kagawa T, Kimura Y, Takada D, Moritake K, Hoshii Y. Supratentorial primitive neuroectodermal tumor in an aged patient--case report--. Neurol Med Chir (Tokyo). 2005 Oct;45(10):530-5. PubMed PMID: 16247240.

26: Hotta T. Treatment of T-Cell lymphoma. Hematology. 2005;10 Suppl 1:193-6. Review. PubMed PMID: 16188671.

27: Ishikawa K, Kajita Y, Hasegawa Y, Noda Y, Yoshida J, Nabeshima T. Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report. J Neurooncol. 2005 Sep;74(3):283-6. PubMed PMID: 16187025.

28: Nishibayashi H, Matsuda Y, Uematsu Y, Nakao N, Terada T, Itakura T. [A case of high grade astrocytoma arising in the hand area of precentral gyrus]. No To Shinkei. 2005 Jun;57(6):517-22. Japanese. PubMed PMID: 16026048.

29: Kitamura K, Takeuchi J, Kanbe E, Oka H, Saiki M, Aikawa S, Kura Y, Hatta Y, Yamazaki T, Ito T, Sawada U, Horie T. [Multiple myeloma of the IgD-lambda type invading CNS]. Rinsho Ketsueki. 2004 Oct;45(10):1124-8. Japanese. PubMed PMID: 15553049.

30: Tsujioka T, Wada H, Suemori S, Sadahira Y, Sugihara T. [CD56-positive peripheral T-cell lymphoma primarily presenting with tonsillar swelling]. Rinsho Ketsueki. 2004 Oct;45(10):1119-23. Japanese. PubMed PMID: 15553048.

31: Sugimoto T, Kitade T, Mimura T, Koyama T, Hatta T, Kurisu S, Kodama K, Wakatsuki S. Infrainguinal bypass surgery for chronic arterial occlusive disease associated with essential thrombocythemia: report of a case. Surg Today. 2004;34(7):632-5. PubMed PMID: 15221564.

32: Kusaba N, Yoshida H, Ohkubo F, Mishima K, Shimamastu K, Okamura T, Sata M. [Granulocyte-colony stimulating factor-producing myeloma with clinical manifestations mimicking chronic neutrophilic leukemia]. Rinsho Ketsueki. 2004 Mar;45(3):228-32. Review. Japanese. PubMed PMID: 15103937.

33: Yamamoto Y, Ishii K, Nomura S, Fukuhara S. [Clonal Ph-negative hematopoiesis with trisomy 8 in chronic myeloid leukemia during imatinib therapy]. Rinsho Ketsueki. 2004 Feb;45(2):164-6. Japanese. PubMed PMID: 15045827.

34: Uzuka T, Takahashi H, Tanaka R, Nishibori T, Tsukada H, Gejyo F. [Pneumocystis carinii pneumonia complicating brain tumor]. No Shinkei Geka. 2004 Feb;32(2):127-33. Japanese. PubMed PMID: 15031973.

35: Takenaka T, Itoh K, Suzuki T, Utsunomiya A, Matsuda S, Chou T, Sai T, Sano M, Konda S, Ohno T, Mikuni C, Deura K, Yamada T, Mizorogi F, Nagoshi H, Tomonaga M, Hotta T, Kawano K, Tsushita K, Hirano M, Shimoyama M; Lymphoma Study Group of the Japan Clinical Oncology Group. Phase III study of ranimustine, cyclophosphamide, vincristine, melphalan, and prednisolone (MCNU-COP/MP) versus modified COP/MP in multiple myeloma: a Japan clinical oncology group study, JCOG 9301. Int J Hematol. 2004 Feb;79(2):165-73. PubMed PMID: 15005346.

36: Arimura K, Arima N, Hamada H, Kukita T, Matsushita K, Tei C. Cardiac lymphoma successfully treated with high dose chemotherapy followed by autologous haematopoietic stem cell transplantation. Haematologica. 2003 Dec;88(12):ECR34. PubMed PMID: 14688007.

37: Fukushima T, Yamamoto M, Oshiro S, Tsugu H, Hirakawa K, Soma G. Recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2) immunotherapy with ranimustine chemotherapy and concurrent radiation therapy for malignant astrocytomas. Anticancer Res. 2003 Nov-Dec;23(6a):4473-81. PubMed PMID: 14666736.

38: Arai M, Kashihara K, Kaizaki Y, Taguchi M, Kitamura Y. [Gliomatosis cerebri: report of 3 cases and review of recent literatures]. No To Shinkei. 2003 Oct;55(10):890-7. Review. Japanese. PubMed PMID: 14635518.

39: Kageji T, Nagahiro S, Horiguchi H, Watanabe T, Suzuya H, Okamoto Y, Kuroda Y. Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. J Neurooncol. 2003 May;62(3):281-7. PubMed PMID: 12777080.

40: Umeda M, Iijima K, Arai C, Katoh M. [Therapeutic effectiveness of ranimustine chemotherapy for essential thrombocythemia in the elderly]. Nippon Ronen Igakkai Zasshi. 2002 Nov;39(6):626-30. Japanese. PubMed PMID: 12518414.

41: Kanaji N, Ishibashi K, Uno H, Hino N. [A patient with mantle cell lymphoma who successfully underwent auto-PBSCT in combination with in vivo purging of tumor cells using rituximab]. Gan To Kagaku Ryoho. 2002 Dec;29(13):2569-72. Japanese. PubMed PMID: 12506485.

42: Kurosawa M, Iwasaki H. Megakaryoblastic transformation of polycythemia vera with hypercalcemia. Ann Hematol. 2002 Nov;81(11):668-71. Epub 2002 Oct 15. PubMed PMID: 12454709.

43: Tanaka M, Matsuzaki J, Kitami K, Hirokawa M. [A case of primary malignant lymphoma of the pararectal space]. Hinyokika Kiyo. 2002 Sep;48(9):561-4. Japanese. PubMed PMID: 12402484.

44: Shishido N, Inoue A, Morishita H, Kodama M, Hasegawa K, Ishihara H, Aitani M, Kawabata S, Kimura K, Araki Y, Takada Y, Kikui M. [A case of chronic thromboembolic pulmonary hypertension based on essential thrombocythemia]. Nihon Kokyuki Gakkai Zasshi. 2002 Jul;40(7):574-8. Japanese. PubMed PMID: 12382421.

45: Kikuchi M, Inagaki T, Ueda R. [A case of multiple myeloma with infiltration into skeletal muscle after injections of a granulocyte-colony stimulating-factor]. Nippon Ronen Igakkai Zasshi. 2002 Jul;39(4):433-8. Japanese. PubMed PMID: 12187809.

46: Yamamoto M, Oshiro S, Tsugu H, Hirakawa K, Ikeda K, Soma G, Fukushima T. Treatment of recurrent malignant supratentorial astrocytomas with carboplatin and etoposide combined with recombinant mutant human tumor necrosis factor-alpha. Anticancer Res. 2002 Jul-Aug;22(4):2447-53. PubMed PMID: 12174942.

47: Fujii H, Iwai T, Ueda Y, Nakagawa H. [Therapy-related acute myeloid leukemia following double autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma]. Rinsho Ketsueki. 2002 Jun;43(6):482-7. Review. Japanese. PubMed PMID: 12134706.

48: Fukui R, Hata F, Yasoshima T, Honma T, Nomura H, Sasaki K, Nishimori H, Sasaki K, Kutomi G, Ohno K, Oikawa I, Sasaki K, Tarumi K, Ishiyama Y, Kobayashi K, Yamamoto N, Hirata K. Malignant melanoma of the anorectum: report of four cases. Surg Today. 2002;32(6):555-8. PubMed PMID: 12107786.

49: Hirose Y, Masaki Y, Sugai S. Leukemic transformation with trisomy 8 in essential thrombocythemia: a report of four cases. Eur J Haematol. 2002 Feb;68(2):112-6. PubMed PMID: 12061320.

50: Fujiwara H, Arima N, Akasaki Y, Ohtsubo H, Ozaki A, Kukita T, Matsushita K, Arimura K, Suruga Y, Wakamatsu S, Matsumoto T, Hidaka S, Eizuru Y, Tei C. Interferon-alpha therapy following autologous peripheral blood stem cell transplantation for adult T cell leukemia/lymphoma. Acta Haematol. 2002;107(4):213-9. PubMed PMID: 12053149.

51: Mizuno H, Yamao H, Nagura E, Shimizu K, Kamiya O, Takeyama H, Nitta M, Wakita A, Ichikawa A, Kobayashi M, Kawashima K, Saito H; Nagoya Myeloma Cooperative Study Group. Superior efficacy of MMCP regimen compared with VMCP and MMPP regimens in the treatment of multiple myeloma. Intern Med. 2002 Apr;41(4):290-4. PubMed PMID: 11993789.

52: Nakamura M, Satoh M, Kowada S, Satoh H, Tashiro A, Sato F, Masuda T, Hiramori K. Reversible restrictive cardiomyopathy due to light-chain deposition disease. Mayo Clin Proc. 2002 Feb;77(2):193-6. PubMed PMID: 11838655.

53: Katayama S, Kita T, Mammoto T, Kawahara M, Kishi Y. [Perioperative management for radical esophagectomy in a patient with polycythemia vera]. Masui. 2001 Dec;50(12):1345-7. Japanese. PubMed PMID: 11797364.

54: Hashino S, Chiba K, Toyoshima N, Suzuki S, Kurosawa M, Musashi M, Asaka M. Exfoliative esophagitis early after autologous peripheral blood stem cell transplantation. Int J Hematol. 2001 Dec;74(4):461-3. PubMed PMID: 11794705.

55: Nagafuji K, Fujisaki T, Arima F, Ohshima K. L-asparaginase induced durable remission of relapsed nasal NK/T-cell lymphoma after autologous peripheral blood stem cell transplantation. Int J Hematol. 2001 Dec;74(4):447-50. PubMed PMID: 11794702.

56: Matano S, Kobayashi K, Ohta H, Minouchi K, Sanada T, Sugimoto T. Prophylactic effect of interferon-alpha for exacerbation of hepatitis B after high-dose chemotherapy. Acta Haematol. 2001;106(3):138-40. PubMed PMID: 11713383.

57: Tang S, Huang D, Wang J, Wei X, Ran C, Peng Y, Lu S, Zhang J. Application of autologous peripheral blood stem cell transplantation in children with malignant tumor. Chin Med J (Engl). 2001 Oct;114(10):1098-101. PubMed PMID: 11677775.

58: Iwakiri R, Mikoshiba M, Tsutsumi H, Kumakawa T, Sawabe M, Arai T, Ohta M, Ezaki Y, Mori M. [A case of malignant lymphoma concomitant with multiple myeloma]. Nippon Ronen Igakkai Zasshi. 2001 Sep;38(5):678-81. Japanese. PubMed PMID: 11605218.

59: Kanno M, Nakamura S, Danno D, Uotani C, Kotani T, Yamanaka S, Terasaki Y, Matano S, Okumura H. [Gross spreading multiple extramedullary plasmacytomas to the skin in the terminal stage of multiple myeloma]. Rinsho Ketsueki. 2001 Jul;42(7):554-8. Japanese. PubMed PMID: 11524846.

60: Takagi T, Sawamura M, Sezaki T, Kashimura M, Tsuchiya J, Hotta T, Ogawa N, Hirashima K. Clinical benefits of lenograstim in patients with neutropenia due to chemotherapy for multiple myeloma (MM). Support Care Cancer. 2001 Jul;9(5):397-9. PubMed PMID: 11497396.

61: Yokoo H, Kamiya M, Sasaki A, Hirato J, Nakazato Y, Kurachi H. Neurofibromatosis type 1-associated unusual pleomorphic astrocytoma displaying continual malignant progression. Pathol Int. 2001 Jul;51(7):570-7. PubMed PMID: 11472572.

62: Tabata M, Kodama K, Matsuo T. Peripheral blood stem cell transplantation in patients over 65 years old with malignant lymphoma--possibility of early completion of chemotherapy and improvement of performance status. Intern Med. 2001 Jun;40(6):471-4. PubMed PMID: 11446668.

63: Takemori N, Kondo K, Kawamura T, Imai K, Sakurai H, Sato T. Satisfactory remission in a case of IgD myeloma: effectiveness of glucocorticoid treatment. Am J Hematol. 2001 Jan;66(1):62-3. PubMed PMID: 11426497.

64: Yamada Y, Tomonaga M, Fukuda H, Hanada S, Utsunomiya A, Tara M, Sano M, Ikeda S, Takatsuki K, Kozuru M, Araki K, Kawano F, Niimi M, Tobinai K, Hotta T, Shimoyama M. A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol. 2001 May;113(2):375-82. PubMed PMID: 11380402.

65: Daibata M, Hatakeyama N, Kamioka M, Nemoto Y, Hiroi M, Miyoshi I, Taguchi H. Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma. Am J Hematol. 2001 Jul;67(3):200-5. PubMed PMID: 11391720.

66: Wakabayashi T, Kajita Y, Mizuno M, Nagasaka T, Yoshida J. Efficacy of adjuvant therapy with procarbazine, MCNU, and vincristine for oligodendroglial tumors. Neurol Med Chir (Tokyo). 2001 Mar;41(3):115-9; discussion 119-20. PubMed PMID: 11372553.

67: Uzuka T, Tanaka R, Takahashi H, Kakinuma K, Matsuda J, Kato K. Planning of hyperthermic treatment for malignant glioma using computer simulation. Int J Hyperthermia. 2001 Mar-Apr;17(2):114-22. PubMed PMID: 11252356.

68: Yamaguchi M, Kimura M, Watanabe Y, Taniguchi M, Masuya M, Kageyama S, Katayama N, Ohno T, Kita K, Shiku H. Successful autologous peripheral blood stem cell transplantation for relapsed intravascular lymphomatosis. Bone Marrow Transplant. 2001 Jan;27(1):89-91. PubMed PMID: 11244443.

69: Wakabayashi T, Hatano N, Kajita Y, Yoshida T, Mizuno M, Taniguchi K, Ohno T, Nagasaka T, Yoshida J. Initial and maintenance combination treatment with interferon-beta, MCNU (Ranimustine), and radiotherapy for patients with previously untreated malignant glioma. J Neurooncol. 2000 Aug;49(1):57-62. PubMed PMID: 11131987.

70: Tsujimura H, Takagi T, Tamaru J, Sakai C. Involvement of the appendix in a relapsed case of primary nasal NK/T-cell lymphoma. Leuk Lymphoma. 2000 May;37(5-6):633-4. PubMed PMID: 11042526.

71: Tanigawa M, Tamaki S, Fujieda A, Miyashita H, Tanaka K, Ichioka M, Taniguchi M, Tsuji K, Miyanishi E. [Aggressive transformation and extramedullary tumor formation in IgA-lambda multiple myeloma]. Rinsho Ketsueki. 2000 Aug;41(8):635-40. Japanese. PubMed PMID: 11020990.

72: Yamane T, Hino M, Ohta K, Koh KR, Nakamae H, Aoyama Y, Ota T, Kishida T, Mugitani A, Sannomiya Y, Kamitani T, Takubo T, Tatsumi N. [High-dose chemotherapy with autologous peripheral blood stem cell transplantation for treatment of non-Hodgkin's lymphoma]. Gan To Kagaku Ryoho. 2000 Sep;27(10):1547-55. Japanese. PubMed PMID: 11016000.

73: Wakabayashi T, Kajita Y, Hatano N, Thompson T, Nagasaka T, Yoshida J. Clinicopathological study of oligodendroglial tumors: the effectiveness of interferon beta, ACNU/MCNU, and radiation (IAR/IMR) for anaplastic tumors. Brain Tumor Pathol. 2000;17(1):29-33. PubMed PMID: 10982007.

74: Hatano N, Wakabayashi T, Kajita Y, Mizuno M, Ohno T, Nakayashiki N, Takemura A, Yoshida J. Efficacy of post operative adjuvant therapy with human interferon beta, MCNU and radiation (IMR) for malignant glioma: comparison among three protocols. Acta Neurochir (Wien). 2000;142(6):633-8; discussion 639. PubMed PMID: 10949437.

75: Wada M, Mizoguchi H, Kuriya SI, Taguchi H, Kawamura T, Maekawa I, Shimazaki C, Sato Y, Niho Y, Miyazaki T, Shibata A, Kitani T, Hamajima N, Ohno R. Induction therapy consisting of alternating cycles of ranimustine, vincristine, melphalan, dexamethasone and interferon alpha (ROAD-IN) and a randomized comparison of interferon alpha maintenance in multiple myeloma: a co-operative study in Japan. Br J Haematol. 2000 Jun;109(4):805-14. PubMed PMID: 10929034.

76: Sahara N, Ihara M, Ono T, Tamashima S, Matsui H, Takeshita A, Ohno R. Multiple myeloma expressing CD19(+)CD56(-) phenotype. Am J Hematol. 2000 Aug;64(4):311-3. PubMed PMID: 10911386.

77: Muroi K, Suzuki T, Amemiya Y, Yoshida M, Kawano C, Kuribara R, Otsuki T, Izumi T, Tomizuka H, Komatsu N, Imagawa S, Hatake K, Miura Y, Ozawa K. Autologous peripheral blood stem cell transplantation for adults with B-lineage acute lymphoblastic leukemia: a pilot study. Leuk Lymphoma. 2000 Jun;38(1-2):103-11. PubMed PMID: 10811452.

78: Yamamoto M, Fukushima T, Hayashi S, Ikeda K, Tsugu H, Kimura H, Soma G, Tomonaga M. Correlation of the expression of nuclear factor-kappa B, tumor necrosis factor receptor type 1 (TNFR 1) and c-Myc with the clinical course in the treatment of malignant astrocytomas with recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2). Anticancer Res. 2000 Jan-Feb;20(1C):611-8. PubMed PMID: 10769704.

79: Sasaki M, Matsue K, Takeuchi M, Mitome M, Hirose Y. Successful treatment of disseminated nasal NK/T-cell lymphoma using double autologous peripheral blood stem cell transplantation. Int J Hematol. 2000 Jan;71(1):75-8. PubMed PMID: 10729998.

80: Togawa A, Mizoguchi H, Toyama K, Urabe A, Ohasi Y, Takaku F. [Clinical evaluation of rhG-CSF in patients with neutropenia induced by chemotherapy for multiple myeloma]. Rinsho Ketsueki. 2000 Feb;41(2):115-22. Japanese. PubMed PMID: 10723240.

81: Sano K, Hayakawa A, Piao JH, Kosaka Y, Nakamura H. Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23). Blood. 2000 Feb 1;95(3):1066-8. PubMed PMID: 10648423.

82: Nawa Y, Takenaka K, Shinagawa K, Deguchi S, Matsumura N, Koyama S, Hiramatsu Y, Omoto E, Yoshino T, Harada M. Successful treatment of advanced natural killer cell lymphoma with high-dose chemotherapy and syngeneic peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999 Jun;23(12):1321-2. PubMed PMID: 10414923.

83: Nagai M, Bandoh S, Tasaka T, Fujita M, Yamauchi A, Kuwabara H, Funamoto Y, Yamaoka G, Takahara J. Secondary myeloid/natural killer cell precursor acute leukemia following essential thrombocythemia. Hum Pathol. 1999 Jul;30(7):868-71. PubMed PMID: 10414508.

84: Fujimoto S, Chikazawa H. Schedule-dependent and -independent antitumor activity of paclitaxel-based combination chemotherapy against M-109 murine lung carcinoma in vivo. Jpn J Cancer Res. 1998 Dec;89(12):1343-51. PubMed PMID: 10081496.

85: Fukushima T, Yamamoto M, Ikeda K, Tsugu H, Kimura H, Soma G, Tomonaga M. Treatment of malignant astrocytomas with recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2). Anticancer Res. 1998 Sep-Oct;18(5D):3965-70. PubMed PMID: 9854511.

86: Mizumatsu S, Matsumoto K, Maeda Y, Tamiya T, Furuta T, Ohmoto T. [A clinical evaluation of combination therapy with radiation, MCNU, carboplatin and IFN-beta or with radiation, MCNU, carboplatin, etoposide and IFN-beta for malignant gliomas]. Gan To Kagaku Ryoho. 1998 Nov;25(13):2055-60. Japanese. PubMed PMID: 9838907.

87: Kawano Y, Takaue Y, Mimaya J, Horikoshi Y, Watanabe T, Abe T, Shimizu Y, Matsushita T, Kikuta A, Watanabe A, Iwai A, Ito E, Endo M, Kodani N, Ohta S, Gushi K, Azuma H, Etoh T, Okamoto Y, Amano K, Hattori H, Eguchi H, Kuroda Y. Marginal benefit/disadvantage of granulocyte colony-stimulating factor therapy after autologous blood stem cell transplantation in children: results of a prospective randomized trial. The Japanese Cooperative Study Group of PBSCT. Blood. 1998 Dec 1;92(11):4040-6. PubMed PMID: 9834207.

88: Takeuchi M, Tamaoki A, Tada A, Jyo Y, Nomura S, Takahashi K, Ohsawa G, Kibata M. Crescentic glomerulonephritis developing 3 months after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma. Bone Marrow Transplant. 1998 Oct;22(7):725-7. PubMed PMID: 9818704.

89: Tsuji A. P-glycoprotein-mediated efflux transport of anticancer drugs at the blood-brain barrier. Ther Drug Monit. 1998 Oct;20(5):588-90. Review. PubMed PMID: 9780140.

90: Fujii H, Nakagawa H, Nakao M, Sonoda Y, Tanimukai S. [Successful double peripheral blood stem cell transplantation for patient with malignant lymphoma of primary induction failure]. Rinsho Ketsueki. 1998 May;39(5):369-73. Japanese. PubMed PMID: 9637887.

91: Otsuki T, Sakaguchi H, Yamada O, Yawata Y, Ueki A. Effect of the nitrosourea anti-tumor chemotherapeutical agent MCNU on five human myeloma cell lines. Oncol Rep. 1998 Jul-Aug;5(4):827-32. PubMed PMID: 9625826.

92: Tsujita Y, Iwao N, Makino S, Ohsawa N. [Syndrome of inappropriate secretion of antidiuretic hormone and neurotoxicity induced by vincristine and alkylating agents during chemotherapy for malignant lymphoma of thyroid gland]. Gan To Kagaku Ryoho. 1998 Apr;25(5):757-60. Japanese. PubMed PMID: 9571977.

93: Kajiume T, Kawano Y, Takaue Y, Abe T, Watanabe T, Okamoto Y, Makimoto A, Suenaga K, Suzuya H, Sato J, Yokobayashi A, Hashimoto T, Yoshida K, Ishibashi H, Takehara H, Tashiro S, Kuroda Y. New consecutive high-dose chemotherapy modality with fractionated blood stem cell support in the treatment of high-risk pediatric solid tumors: a feasibility study. Bone Marrow Transplant. 1998 Jan;21(2):147-51. PubMed PMID: 9489631.

94: Matsumoto K, Nakagawa T, Tada E, Furuta T, Hiraki Y, Ohmoto T. Effect of adjuvant iridium-192 brachytherapy on the survival of patients with malignant gliomas. Neurol Med Chir (Tokyo). 1997 Dec;37(12):891-9; discussion 899-900. PubMed PMID: 9465587.

95: Nagai T, Hirayama Y, Ohta H, Koyama R, Matsunaga T, Kuga T, Sakamaki S, Niitsu Y. [Successful high-dose chemotherapy combined with autologous bone marrow transplantation in a case of refractory follicular lymphoma]. Rinsho Ketsueki. 1997 Jun;38(6):513-9. Japanese. PubMed PMID: 9248327.

96: Maeda Y, Matsumoto K, Kuriyama M, Ono Y, Kunishio K, Tamiya T, Furuta T, Ohmoto T. [Clinical study of primary central nervous system lymphoma: the role of chemotherapy]. Gan To Kagaku Ryoho. 1997 May;24(7):807-13. Japanese. PubMed PMID: 9170518.

97: Nagura E, Ichikawa A, Kamiya O, Kato R, Utsumi M, Tanaka M, Takeyama H, Shimizu K, Kobayashi M, Naito K, Nishiwaki H, Mizuno H, Hirabayashi N, Nitta M, Kato Y, Shibata T, Hotta T, Kawashima K, Saito H. A randomized study comparing VMCP and MMPP in the treatment of multiple myeloma. Cancer Chemother Pharmacol. 1997;39(4):279-85. PubMed PMID: 9025767.

98: Ishii E, Matsuzaki A, Ohnishi Y, Kai T, Ueda K. Successful treatment with ranimustine and carboplatin for recurrent intraocular retinoblastoma with vitreous seeding. Am J Clin Oncol. 1996 Dec;19(6):562-5. PubMed PMID: 8931671.

99: Harashima S, Okamura T, Umeno M, Takaki K. [A case of myelofibrosis that developed polycythemia vera following treatment with ranimustine and then acute myelogenous leukemia (M0)]. Rinsho Ketsueki. 1996 Aug;37(8):713-8. Japanese. PubMed PMID: 8827883.

100: Taguchi H. [An intensive chemotherapy of adult T-cell leukemia/lymphoma]. Rinsho Ketsueki. 1996 Aug;37(8):654-60. Japanese. PubMed PMID: 8827873.

101: Sasajima T, Mineura K, Kowada M, Watanabe A, Takeda O. [Usefulness and problems of high dose chemotherapy using CBDCA, VP-16, and MCNU with peripheral blood stem cell transplantation in pediatric malignant brain tumors]. No To Shinkei. 1996 Jul;48(7):653-8. Japanese. PubMed PMID: 8753001.

102: Taguchi H, Kinoshita KI, Takatsuki K, Tomonaga M, Araki K, Arima N, Ikeda S, Uozumi K, Kohno H, Kawano F, Kikuchi H, Takahashi H, Tamura K, Chiyoda S, Tsuda H, Nishimura H, Hosokawa T, Matsuzaki H, Momita S, Yamada O, Miyoshi I. An intensive chemotherapy of adult T-cell leukemia/lymphoma: CHOP followed by etoposide, vindesine, ranimustine, and mitoxantrone with granulocyte colony-stimulating factor support. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):182-6. PubMed PMID: 8680890.

103: Nagatoshi Y, Okamura J, Ikuno Y, Tasaka H. An adolescent case of retroperitoneal pure choriocarcinoma: successful treatment with MCNU-containing high-dose chemotherapy followed by autologous bone marrow transplantation after multiple brain metastases. Pediatr Hematol Oncol. 1996 Mar-Apr;13(2):167-71. PubMed PMID: 8721032.

104: Awaya N, Takao M, Natsuda H, Yamawaki T, Suzuki N, Takayama N, Ishida A, Kawai Y. [Erythroblastic transformation of chronic myelogenous leukemia associated with an additional chromosome abnormality translocation (6;9]. Rinsho Ketsueki. 1995 Nov;36(11):1300-4. Japanese. PubMed PMID: 8691572.

105: Nishio S, Morioka T, Takeshita I, Shono T, Inamura T, Fujiwara S, Fukui M. Chemotherapy for progressive pilocytic astrocytomas in the chiasmo-hypothalamic regions. Clin Neurol Neurosurg. 1995 Nov;97(4):300-6. PubMed PMID: 8599896.

106: Nishimiya J, Yamaji Y, Nitta T, Mori H, Yamamura A, Shirai T, Kondo T, Sato K, Mizuno Y. [A 49-year-old man with progressive dysarthria, dysphagia, and left hemiparesis]. No To Shinkei. 1995 Nov;47(11):1109-18. Japanese. PubMed PMID: 7495619.

107: Yamasaki T, Nagao S, Kagawa T, Konishi S, Akiyama Y, Fukuda M, Kimura Y, Moritake K. [Intratumoral pharmacokinetics following intraarterial administration of MCNU in patients with malignant gliomas]. No Shinkei Geka. 1995 Nov;23(11):963-9. Japanese. PubMed PMID: 7477717.

108: Yamasaki T, Konishi S, Kagawa T, Nagai H, Nagao S, Moritake K. [The efficacy of granisetron as a prophylactic anti-emetic agent used in conjunction with MCNU and VP16 chemotherapeutic regimens in the management of a pediatric case of hypothalamic anaplastic astrocytoma]. Gan To Kagaku Ryoho. 1995 Sep;22(10):1397-402. Japanese. PubMed PMID: 7668877.

109: Matsuzaki A, Okamura J, Nagatoshi Y, Kai T, Ohga S, Gondo H, Inaba S, Ueda K. Treatment of young relapsed Hodgkin's disease patients with high-dose chemotherapy followed by peripheral blood stem cell transplantation. Leuk Lymphoma. 1995 Aug;18(5-6):505-9. PubMed PMID: 8528060.

110: Ryu T, Asai K, Sugasawa G, Seta K, Kitamura S, Inoue N. [Peripheral blood stem cell transplantation for rapidly spreading myeloma]. Rinsho Ketsueki. 1995 Aug;36(8):749-54. Japanese. PubMed PMID: 7563608.

111: Abe T, Takaue Y, Okamoto Y, Yamaue T, Nakagawa R, Makimoto A, Sato J, Kawano Y, Kuroda Y. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in children undergoing high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Pediatr Hematol Oncol. 1995 Jul-Aug;12(4):363-9. PubMed PMID: 7577388.

112: Ohtsuka E, Tezono K, Saburi Y, Kikuchi H, Nasu M, Satoh J, Taniguchi K, Nagano T. [Essential thrombocythemia transformed to minimally differentiated acute myeloid leukemia]. Gan To Kagaku Ryoho. 1995 Jun;22(7):941-4. Japanese. PubMed PMID: 7794000.

113: Watanabe M, Takeda N, Tanaka R. [Effect of intra-arterial and local administration of MCNU on cerebral malignant gliomas]. Gan To Kagaku Ryoho. 1995 May;22(6):811-4. Japanese. PubMed PMID: 7755390.

114: Kannuki S, Bando K, Shirakawa N, Matsumoto K, Takaue Y, Kuroda Y. [Intensive and high-dose chemotherapy with peripheral blood stem cell transfusion for pediatric malignant brain tumor]. No Shinkei Geka. 1995 May;23(5):411-5. Japanese. PubMed PMID: 7753320.

115: Sadahiro M, Hino H, Senoo S. [A case report: abdominal aorta-femoral artery bypass grafting in patient with essential thrombocythemia]. Nippon Geka Gakkai Zasshi. 1995 Mar;96(3):198-201. Japanese. PubMed PMID: 7731463.

116: Tsuruoka N. [Waldenström's macroglobulinemia]. Nippon Rinsho. 1995 Mar;53(3):725-9. Review. Japanese. PubMed PMID: 7699913.

117: Koyama S. [The role of interferon-alpha in the treatment of multiple myeloma]. Nippon Rinsho. 1995 Mar;53(3):658-63. Review. Japanese. PubMed PMID: 7699901.

118: Takeyama H, Shimokawa T, Yamada H, Watanabe E. [A clinical study of sixteen polycythemia vera cases--acute myeloblastic leukemia in patients with polycythemia vera]. Gan To Kagaku Ryoho. 1994 Dec;21(16):2833-7. Japanese. PubMed PMID: 7993124.

119: Tatsumi T, Okada M, Yoneda Y, Maki K, Ura Y, Sawada K, Hino R, Goto H, Fujita N, Shimazaki C, et al. [Multiple myeloma with massive ascites fluid--immunophenotypic analysis of myeloma cell and its IL-6-dependent growth]. Rinsho Ketsueki. 1994 Dec;35(12):1361-5. Japanese. PubMed PMID: 7861616.

120: Shinohara C, Matsumoto K, Kuriyama M, Adachi H, Ono Y, Higashi H, Furuta T, Ohmoto T. [Clinical pharmacokinetics of carboplatin and MCNU in malignant brain tumor and normal brain tissues]. Gan To Kagaku Ryoho. 1994 Jul;21(8):1163-8. Japanese. PubMed PMID: 8031157.

121: Inoue N, Miyazaki E, Okada M, Wada H, Nishimura T, Tamura S, Fujimori Y, Okamoto T, Takemoto Y, Kosaki M, et al. [MECHOP-BM chemotherapy in the treatment of non Hodgkin's lymphoma]. Rinsho Ketsueki. 1994 Jun;35(6):535-40. Japanese. PubMed PMID: 8078187.

122: Takaue Y, Abe T, Kawano Y, Suzue T, Saito S, Hirao A, Sato J, Makimoto A, Kawahito M, Watanabe T, et al. Comparative analysis of engraftment after cryopreservation of peripheral blood stem cell autografts by controlled- versus uncontrolled-rate methods. Bone Marrow Transplant. 1994 Jun;13(6):801-4. PubMed PMID: 7920317.

123: Yamane T, Ohta T, Kou KR, Hashimoto S, Takekawa K, Hirai N, Tanaka K, Hasuike T, Hirai M, Ohta K, et al. [Therapeutic effects of peripheral blood stem cell transplantation following combination chemotherapy using ranimustine, cytarabine, etoposide and cyclophosphamide for patients with hematological malignancies]. Gan To Kagaku Ryoho. 1994 May;21(6):903-6. Japanese. PubMed PMID: 7910450.

124: Ashihara E, Shimazaki C, Yamagata N, Hirata T, Okawa K, Oku N, Goto H, Inaba T, Fujita N, Nakagawa M. Reconstitution of lymphocyte subsets after peripheral blood stem cell transplantation: two-color flow cytometric analysis. Bone Marrow Transplant. 1994 Apr;13(4):377-81. PubMed PMID: 7912603.

125: Imamura Y, Takagi T, Yawata Y, Nishinarita S, Kosaka M, Mikuni C, Takatsuki K, Sezaki T, Mori M, Tsuchiya J, et al. Combination chemotherapy with MCNU, vindesine, melphalan, and prednisolone (MCNU-VMP therapy) in induction therapy for multiple myeloma. Japan Myeloma Study Group. Int J Hematol. 1994 Feb;59(2):113-23. PubMed PMID: 8018904.

126: Watanabe E, Shimokawa T, Kasai M, Yamada H, Takeyama H, Natsume S, Satake T. [Essential thrombocythemia clinical characteristics and course of 10 cases]. Gan To Kagaku Ryoho. 1994 Jan;21(1):119-21. Japanese. PubMed PMID: 8291908.

127: Kanauchi M, Dohi K, Shiiki H, Fujii Y, Ishikawa H. Henoch-Schönlein purpura nephritis associated with polycythemia vera. Intern Med. 1994 Jan;33(1):36-40. PubMed PMID: 8180441.

128: Takaue Y, Watanabe A, Murakami T, Watanabe T, Kawano Y, Kuroda Y, Matsushita T, Kikuta A, Kosaka Y, Kudo T, et al. High-dose chemotherapy and blood stem cell autografts for children with first relapsed acute lymphoblastic leukemia: a pilot study of the Children's Cancer and Leukemia Study Group of Japan (CCLSG). Med Pediatr Oncol. 1994;23(1):20-5. PubMed PMID: 7909913.

129: Hotta T, Saito Y, Fujita H, Mikami T, Kurisu K, Kiya K, Uozumi T, Isowa G, Ishizaki K, Ikenaga M. O6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications. J Neurooncol. 1994;21(2):135-40. PubMed PMID: 7861189.

130: Kochi M, Takaki S, Kuratsu J, Seto H, Kitamura I, Ushio Y. Neurotoxicity and pharmacokinetics of ventriculolumbar perfusion of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) in dogs. J Neurooncol. 1994;19(3):239-44. PubMed PMID: 7807174.

131: Wake A, Yamasaki Y, Ogawa R, Mori N, Nagata K, Nakata K, Misago M, Izumi Y, Fujita K, Oda S, et al. [Successful treatment by ranimustine (MCNU) of a patient with B-cell prolymphocytic leukemia (B-PLL)]. Rinsho Ketsueki. 1993 Nov;34(11):1464-9. Japanese. PubMed PMID: 8254909.

132: Shinohara C, Matsumoto K, Nakagawa M, Ono Y, Higashi H, Tsuno K, Maeshiro T, Tamiya T, Furuta T, Ohmoto T. [Preliminary results of a combination therapy of irradiation, MCNU, carboplatin (CBDCA) and IFN-beta (MCI therapy) for gliomas]. Gan To Kagaku Ryoho. 1993 Oct;20(13):2067-9. Japanese. PubMed PMID: 8215484.

133: Yamada K, Nakamaki T, Yokoyama A, Hino K, Tomoyasu S, Sakurai M, Tsuruoka N. [Sideroblastic anemia preceded by essential thrombocythemia with 20q- chromosome abnormality]. Rinsho Ketsueki. 1993 Sep;34(9):1027-32. Japanese. PubMed PMID: 8230746.

134: Murata M, Nagai M, Bando S, Dobashi H, Takahara J. Emergence of acute interstitial pneumonia following high dose interferon delta treatment in a case of chronic myelogenous leukemia. Intern Med. 1993 Sep;32(9):716-8. PubMed PMID: 8142676.

135: Okamoto R, Harano H, Tamura T, Tanabe J, Fujita H, Fukawa H, Kanamori H, Matsuźaki M, Motomura S, Mohri H, et al. [Neutrophilic myelofibrosis; a case report]. Rinsho Ketsueki. 1993 Aug;34(8):957-61. Japanese. PubMed PMID: 8411651.

136: Sato M, Kanai N, Yamamoto S, Take H, Kuyama J, Shiraki T, Ozaki M, Kanayama Y, Hayakawa T. [Giant plasmacytoma of the skull which appeared in the clinical course of multiple myeloma--a case report]. No To Shinkei. 1993 Aug;45(8):753-7. Japanese. PubMed PMID: 8217400.

137: Hotta T, Saito Y, Mikami T, Kurisu K, Kiya K, Uozumi T, Isowa G, Ishizaki K, Ikenaga M. Interrelationship between O6-alkylguanine-DNA alkyltransferase activity and susceptibility to chloroethylnitrosoureas in several glioma cell lines. J Neurooncol. 1993 Jul;17(1):1-8. PubMed PMID: 8120566.

138: Kiya K, Uozumi T, Kurisu K, Mikami T, Sugiyama K, Monden S, Maeda H, Matsuoka T, Matsuda Y, Harada K, et al. [Study on three patients with malignant glioma showing tumor reduction during maintenance therapy with MCNU]. Gan To Kagaku Ryoho. 1993 Jun;20(8):1083-6. Japanese. PubMed PMID: 8512339.

139: Murakami H, Tamura J, Sawamura M. MCNU in the treatment of essential thrombocythemia--a pilot study. Ann Hematol. 1993 May;66(5):247-9. PubMed PMID: 8507720.

140: Kitani T. [New protocols for myeloma chemotherapy plus IFN alpha]. Rinsho Ketsueki. 1993 Apr;34(4):455-9. Japanese. PubMed PMID: 8510333.

141: Togawa A. [Recent therapy for refractory myeloma]. Rinsho Ketsueki. 1993 Apr;34(4):450-4. Japanese. PubMed PMID: 8510332.

142: Tokiwa F, Utsunomiya A, Nakahara K, Shimotakahara S, Takeshita T, Makino T, Hanada S, Arima T. [A case of refractory multiple myeloma effectively treated with long-term oral etoposide]. Gan To Kagaku Ryoho. 1993 Mar;20(4):533-6. Japanese. PubMed PMID: 8452392.

143: Nozaki H, Usui T, Yamauchi K, Kobayashi N, Nakamura Y, Watanabe K, Nagao T, Arimori S. [Hematologic response to low dose natural interferon-alpha in a case of CML with myelo-megakaryoblastic crisis]. Rinsho Ketsueki. 1993 Feb;34(2):232-4. Japanese. PubMed PMID: 8492424.

144: Hodozuka A, Sako K, Nakai H, Tomabechi M, Suzuki N, Yonemasu Y. Delivery of a novel nitrosourea, MCNU, to the brain tissue in glioma-bearing rats. Intracarotid versus intravenous infusion. J Neurooncol. 1993 Jan;15(1):79-86. PubMed PMID: 8455066.

145: Yamashima T, Ohnishi T, Nakajima Y, Terasaki T, Tanaka M, Yamashita J, Sasaki T, Tsuji A. Uptake of drugs and expression of P-glycoprotein in the rat 9L glioma. Exp Brain Res. 1993;95(1):41-50. PubMed PMID: 8104817.

146: Kubota R, Kubota K, Yamada S. [Enhancement of the effects of anticancer agents on B16 melanoma cells by combination with cepharanthine--II. Antimetabolite, alkylating agent, nitrosourea]. Gan To Kagaku Ryoho. 1992 Nov;19(13):2169-74. Japanese. PubMed PMID: 1444482.

147: Takahashi N, Chubachi A, Watanabe S, Nishinari T, Nimura T, Imai H, Fukushima Y, Miura AB. [Isolated cerebellar tumor formation in a patient with blastic crisis of chronic myelogenous leukemia]. Rinsho Ketsueki. 1992 Sep;33(9):1257-62. Japanese. PubMed PMID: 1433948.

148: Sakai C, Takagi T, Oguro M. [BH-AC.nitrosourea-therapy for refractory or relapsed malignant lymphoma]. Gan To Kagaku Ryoho. 1992 Jun;19(6):843-7. Japanese. PubMed PMID: 1605662.

149: Tanaka H, Kawano M, Iwato K, Asaoku H, Tanabe O, Ishikawa H, Nobuyoshi M, Sakai A, Kuramoto A. [Study on the therapy of multiple myelomas--initial induction therapy (MP, IFN alpha, steroid pulse) and maintenance therapy (VMP, MP continuous, VEP, MCNU)]. Rinsho Ketsueki. 1992 May;33(5):655-61. Japanese. PubMed PMID: 1630017.

150: Akimoto Y, Ishiyama T, Sano M, Ueno H, Nakamaki T, Hino K, Tomoyasu S, Tsuruoka N. [Essential thrombocythemia that transformed to myelofibrosis after three years]. Rinsho Ketsueki. 1992 Apr;33(4):520-4. Japanese. PubMed PMID: 1602618.

151: Mineura K, Ishiyama Y, Kowada M. Cross-resistance pattern in brain tumour cells resistant to antitumour chloroethylnitrosoureas. Neurol Res. 1992 Mar;14(1):45-8. PubMed PMID: 1351258.

152: Matsubara S, Ebisudani D, Ohshima T, Matsumoto K, Hirose T, Hizawa K. [A case of metastatic intracerebral malignant schwannoma]. No Shinkei Geka. 1992 Feb;20(2):187-90. Review. Japanese. PubMed PMID: 1542399.

153: Murakawa M, Okamura T, Tsutsumi K, Tanoguchi S, Kamura T, Shibuya T, Harada M, Niho Y. Acquired von Willebrand's disease in association with essential thrombocythemia: regression following treatment. Acta Haematol. 1992;87(1-2):83-7. PubMed PMID: 1585777.

154: Mineura K, Ishiyama Y, Kowada M. Development of resistance to antitumor chloroethylnitrosoureas in vitro in brain tumor cells. Acta Oncol. 1992;31(7):755-9. PubMed PMID: 1476755.

155: Fujimoto S, Tokita H, Nitta K. [Antitumor spectra of ranimustine against various human tumors]. Gan To Kagaku Ryoho. 1991 Nov;18(14):2417-22. Japanese. PubMed PMID: 1952961.

156: Oguro M, Sakai C, Takagi T, Matsuura Y. [In vitro effect of combined use of BH-AC and nitrosourea derivatives against adriamycin-resistant human leukemia cell line]. Gan To Kagaku Ryoho. 1991 Nov;18(14):2403-8. Japanese. PubMed PMID: 1952959.

157: Shoin K, Yamashita J, Enkaku F, Sasaki T, Tanaka M, Endo Y. Chick embryo assay as chemosensitivity test for malignant glioma. Jpn J Cancer Res. 1991 Oct;82(10):1165-70. PubMed PMID: 1955382.

158: Saito Y, Nakada Y, Hotta T, Mikami T, Kurisu K, Yamada K, Kiya K, Kawamoto K, Uozumi T. Cross-resistance patterns in ACNU-resistant glioma sublines in culture. J Neurosurg. 1991 Aug;75(2):277-83. PubMed PMID: 2072167.

159: Sosnovsky G, Rao NU. In the search for new anticancer drugs. XXIII: Exploration of a predictive design for anticancer drugs of carbohydrates containing N-nitrosochloroethylamino, N-nitrosomethyl, and N-nitrosoaminoxyl components. J Pharm Sci. 1991 Jul;80(7):693-9. PubMed PMID: 1658297.

160: Takaue Y, Watanabe T, Hoshi Y, Abe T, Matsunaga K, Saito S, Hirao A, Kawano Y, Ninomiya T, Kuroda Y, et al. Effectiveness of high-dose MCNU therapy and hematopoietic stem cell autografts treatment of childhood acute leukemia/lymphoma with high-risk features. Cancer. 1991 Apr 1;67(7):1830-7. PubMed PMID: 1672260.

161: Maeda S, Okabe M, Kurosawa M, Kunieda Y, Imamura M, Morioka M, Sakurada K, Miyazaki T, Sukegawa M. [Therapeutic effect of ranimustine(MCNU) on myeloproliferative disorder and chronic myelomonocytic leukemia]. Gan To Kagaku Ryoho. 1991 Feb;18(2):251-8. Japanese. PubMed PMID: 1992919.

162: Asano Y, Shimokawa M, Okabe H, Sanefuji H, Kato K. Beneficial treatment with methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside in a patient with primary myelofibrosis. Acta Haematol. 1991;85(2):103-4. PubMed PMID: 2024552.

163: Uzuka Y, Saito Y, Ito T. [Combination chemotherapy of multiple myeloma]. Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 1):1481-7. Japanese. PubMed PMID: 2389944.

164: Tamura M, Ono N, Kurihara H, Ohye C, Miyazaki M. Adjunctive treatment for recurrent childhood ependymoma of the IV ventricle: chemotherapy with CDDP and MCNU. Childs Nerv Syst. 1990 Jun;6(4):186-9. PubMed PMID: 2383872.

165: Yamashima T, Yamashita J, Shoin K. Neurotoxicity of local administration of two nitrosoureas in malignant gliomas. Neurosurgery. 1990 May;26(5):794-9. PubMed PMID: 2352597.

166: Hino N, Matsuura W, Kawakami K, Ono T, Matsumoto T, Tominaga T. [Combination chemotherapy of MCNU and interferon alfa-2a (genetical recombination) for advanced multiple myeloma]. Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 1):693-6. Japanese. PubMed PMID: 2321988.

167: Kanamaru R, Ishioka C, Konishi Y, Ishikawa S, Shibata H, Wakui A. [DNA damage and anticancer effect]. Gan To Kagaku Ryoho. 1990 Mar;17(3 Pt 2):517-23. Review. Japanese. PubMed PMID: 2181939.

168: Masaoka T. [Ranimustine]. Gan To Kagaku Ryoho. 1990 Feb;17(2):301-7. Japanese. PubMed PMID: 2405779.

169: Kiya K, Uozumi T, Kurisu K, Inagawa T, Ohta M, Kajikawa H, Kawashima K, Kitaoka T, Goishi A, Kodama Y, et al. [Randomized study of initial treatment with radiation.MCNU or radiation.MCNU.interferon-beta for malignant glioma. Hiroshima Brain Tumor Study Group]. Gan To Kagaku Ryoho. 1990 Feb;17(2):221-6. Japanese. PubMed PMID: 2405777.

170: Tonn JC, Schönmayr R, Kraemer HP. Sensitivity of human malignant intracranial tumors against MCNU in vitro in comparison to ACNU and BCNU. J Neurooncol. 1990 Feb;8(1):41-5. PubMed PMID: 2319289.

171: Miyagami M, Tazoe M, Tsubokawa T. [MCNU delivery into malignant brain tumor and normal brain tissue by intravenous or intraarterial infusion]. Gan To Kagaku Ryoho. 1990 Feb;17(2):275-80. Japanese. PubMed PMID: 2154161.

172: Mineura K, Fushimi S, Kowada M, Isowa G, Ishizaki K, Ikenaga M. Linkage between O6-methylguanine-DNA methyltransferase (O6-MT) activity and cellular resistance to antitumour nitrosoureas in cultured rat brain tumour cell strains. Acta Neurochir (Wien). 1990;103(1-2):62-6. PubMed PMID: 2360469.

173: Yokote H, Komai N, Nakai E, Itakura T, Hayashi S. Stereotactic hyperthermia for brain tumors. Stereotact Funct Neurosurg. 1990;54-55:506-13. PubMed PMID: 1964243.

174: Kanamaru R, Ishioka C, Konishi Y, Ishikawa A, Shibata H, Wakui A. Damage to DNA strand and the effects of anticancer drugs. Sci Rep Res Inst Tohoku Univ Med. 1989 Dec;36(1-4):29-36. PubMed PMID: 2640065.

175: Shimokawa T, Koyama T, Takaue Y, Watanabe T, Kawano Y, Ninomiya T, Kuroda Y. [Interstitial pneumonitis following high-dose MCNU]. Gan To Kagaku Ryoho. 1989 Dec;16(12):3809-11. Japanese. PubMed PMID: 2574565.

176: Kitajima K, Adachi T, Takahashi I, Nakada H, Osada K, Fukuda S, Ohmoto E, Aoyama S, Yorimitsu S, Sanada H. [Chemotherapy of chronic myelogenous leukemia--VP(M) regimen initiated during its chronic phase, and evaluation of MCNU in the phase of blastic crisis]. Gan To Kagaku Ryoho. 1989 Nov;16(11):3573-9. Japanese. PubMed PMID: 2817908.

177: Takahashi S, Murae M, Tahira K, Yamamoto K, Ochiai K, Kimura E, Morimoto O, Yasuda M, Terashima Y, Dozono H. [Prognostic study of ovarian clear cell carcinoma]. Nippon Gan Chiryo Gakkai Shi. 1989 Jun 20;24(6):1238-42. Japanese. PubMed PMID: 2794647.

178: Uzuka Y, Saito Y, Takahashi H, Komatsu M, Ito T. [Combination chemotherapy of multiple myeloma--BCNU.cyclophosphamide.procarbazine.prednisolone and MCNU.cyclophosphamide.procarbazine.prednisolone therapy]. Gan To Kagaku Ryoho. 1989 Jun;16(6):2269-73. Japanese. PubMed PMID: 2735769.

179: Shiga Y, Matsuoka R, Abe R, Matsuda S, Uchida T, Kariyone S. [The use of MCNU to a patient of primary myelofibrosis complicated with pericardial effusion and proteinuria]. Rinsho Ketsueki. 1989 Apr;30(4):497-501. Japanese. PubMed PMID: 2769970.

180: Kamiya O, Hoshino A, Ohara K, Nagata K, Ono Y, Saito M, Itou T, Yamamoto K. [Combination chemotherapy of MCNU, melphalan, procarbazine, and prednisolone (MMPP) in multiple myeloma; disappearance of M-peak on serum electrophoretic pattern]. Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 1):863-5. Japanese. PubMed PMID: 2469398.

181: Watanabe T, Takaue Y, Koyama T, Kawano Y, Satoh J, Huq MA, Ninomiya T, Kuroda Y, Ueda T, Hiura K. [Rapid and complete hematopoietic reconstitution following peripheral blood stem cell autotransplantation in a child with T cell acute lymphoblastic leukemia]. Rinsho Ketsueki. 1989 Jan;30(1):122-6. Japanese. PubMed PMID: 2565988.

182: Nagai M, Tasaka T, Kamano H, Ohnishi H, Taoka T, Ikeda K, Kubota Y, Tanaka T, Irino S. [Therapeutic effect of ranimustine (MCNU) on essential thrombocythemia and polycythemia vera]. Gan To Kagaku Ryoho. 1988 Dec;15(12):3267-70. Japanese. PubMed PMID: 3196045.

183: Mineura K, Fushimi S, Itoh Y, Kowada M. DNA lability induced by nimustine and ramustine in rat glioma cells. J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1391-4. PubMed PMID: 3236017; PubMed Central PMCID: PMC1032808.

184: Sekido S, Hosono J, Hiratsuka K, Araki T, Iwasaki M. [Pharmacological studies on MCNU: a new antitumor agent]. Nippon Yakurigaku Zasshi. 1988 Aug;92(2):69-96. Japanese. PubMed PMID: 3224900.

185: Mineura K, Fushimi S, Sasajima H, Sasaki J, Ishino Y, Kowada M. [Analysis of DNA damage induced by nitrosourea derivatives in rat brain tumor cells using a sequencing procedure]. Gan To Kagaku Ryoho. 1988 Feb;15(2):307-11. Japanese. PubMed PMID: 3422552.

186: Hiraoka A, Masaoka T, Shibata H, Miyazaki T, Nakamura T, Yasunaga K, Kitani T, Yonezawa T, Kawagoe H, Horiuchi A, et al. A new nitrosourea derivative for the treatment of chronic myelogenous leukemia. Leuk Res. 1988;12(6):487-90. PubMed PMID: 3043111.

187: Kobayashi M, Sugiura I, Yamada K. [Prolonged disappearance of the Ph1 chromosome in a case of chronic myelogenous leukemia after administration of MCNU]. Rinsho Ketsueki. 1987 Sep;28(9):1640-4. Japanese. PubMed PMID: 3481407.

188: Ohnaka T, Ohno T, Kanoh T, Uchino H. [Effect of MCNU on growth kinetics of human plasma cell lines--in comparison with melphalan]. Nippon Ketsueki Gakkai Zasshi. 1987 Aug;50(5):971-7. Japanese. PubMed PMID: 3434146.

189: Kobayashi T, Tanaka I, Shirakawa S, Fujiwara Y, Hirota Y, Kobayashi M, Ohno R, Yamada H, Mitomo Y, Yamamoto M, et al. [Phase II study of a new nitrosourea derivative, MCNU, in tablet form. Takai Blood Cancer Study Group]. Gan To Kagaku Ryoho. 1987 Apr;14(4):1079-85. Japanese. PubMed PMID: 3566304.

190: Saito A, Oride M, Munaka M, Uozumi T. [Discriminant analysis of bone marrow suppression of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU)]. Gan To Kagaku Ryoho. 1987 Feb;14(2):511-5. Japanese. PubMed PMID: 3813579.

191: Kato T, Ota K. [Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia]. Gan To Kagaku Ryoho. 1987 Feb;14(2):502-5. Japanese. PubMed PMID: 2949703.

192: Kanamaru A, Nagai K, Masaoka T, Shibata H, Kitani T, Taniguchi N, Horiuchi A, Tsubaki K, Kawagoe H, Hirata M, et al. [Phase II study on oral administration of MCNU (ranomustine) tablet. Hanshin Cooperative Study Group on Hematological Disorders]. Gan To Kagaku Ryoho. 1986 May;13(5):1915-20. Japanese. PubMed PMID: 3458432.

193: Niimoto M, Yoshinaka K, Hattori T, Kobayashi S, Hosoma S, Ogawa Y, Iwamori S, Nagata N, Yamagata S, Nishimawari K. [Phase II study on MCNU in patients with advanced or recurrent gastrointestinal cancer]. Gan To Kagaku Ryoho. 1985 Sep;12(9):1813-9. Japanese. PubMed PMID: 4037810.

194: Fujimoto S, Ogawa M. Toxicological study on a new nitrosourea derivative, 1-(2-chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1-nitrosourea. Jpn J Cancer Res. 1985 Jul;76(7):651-6. PubMed PMID: 3928562.

195: Harada K, Okamoto H, Fujioka Y, Uozumi T, Kiya K, Kitaoka T, Goishi A, Sasaki U, Shima T, Inagawa T, et al. [Clinical trial of MCNU for malignant brain tumors]. Gan To Kagaku Ryoho. 1985 Jul;12(7):1423-31. Japanese. PubMed PMID: 2990350.

196: Higuchi A, Miyazaki T, Sakurada K, Morioka M, Musashi M, Imamura M, Maekawa I, Saitoh H, Ohtani N, Kasai M, et al. [Phase II study with methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) in hematological malignancies]. Gan To Kagaku Ryoho. 1985 Jun;12(6):1253-9. Japanese. PubMed PMID: 3859250.

197: Masaoka T, Kimura K, Miyazaki T, Hirota Y, Nakamura T, Yasunaga K, Ohkubo H, Okamoto Y, Fujitake H, Kitani T, et al. [Randomized controlled study of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) in comparison with busulfan for chronic myelogenous leukemia]. Gan To Kagaku Ryoho. 1985 May;12(5):1111-8. Japanese. PubMed PMID: 3888116.

198: Nakamura T, Hashimoto E, Sasada M, Tsutani H, Kagawa D, Ueda T, Uchida M, Domae N, Ando S, Uchino H. [Action mechanism of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) in leukemic cells]. Nippon Ketsueki Gakkai Zasshi. 1985 May;48(3):734-41. Japanese. PubMed PMID: 3862320.

199: Tanaka I, Kobayashi T, Shirakawa S, Ikeda Y, Kobayashi M, Yamagata K, Ohta K, Ohno R, Yamada H, Yamada K, et al. [Phase II study of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU).]. Gan To Kagaku Ryoho. 1985 Mar;12(3 Pt 1):493-8. Japanese. PubMed PMID: 3859248.

200: Machida S, Ito Y, Hoshino A. [Effects of combination chemotherapy of MCNU with various anti-cancer agents]. Gan To Kagaku Ryoho. 1985 Feb;12(2):298-302. Japanese. PubMed PMID: 3918506.

201: Murase T, Nagura E, Ohno R. [Prolonged remission in a patient with chronic myelocytic leukemia (CML) by methyl 6-[3-(2-chloroethyl)-3-deoxy-alpha-D-glucopyranoside (MCNU)]. Gan To Kagaku Ryoho. 1984 Dec;11(12 Pt 1):2590-3. Japanese. PubMed PMID: 6594976.

202: Oguro M, Yanagawa T, Takenaga K. [Antitumor activity of a new nitrosourea, MCNU, on a cellular morphological basis evaluated by a new in vitro antitumor sensitivity assay]. Gan To Kagaku Ryoho. 1984 Dec;11(12 Pt 1):2550-6. Japanese. PubMed PMID: 6594974.

203: Wakabayashi T, Yoshida J, Kito A, Inoue I, Kobayashi T, Kageyama N. [Effect of MCNU on brain tumors. Part II: Clinical experience with MCNU on malignant brain tumors]. Gan To Kagaku Ryoho. 1984 Dec;11(12 Pt 2):2729-37. Japanese. PubMed PMID: 6095764.

204: Taguchi T. [A phase II study of ranomustine (MCNU) tablets in patients with gastrointestinal cancer--by cooperative study group]. Gan To Kagaku Ryoho. 1984 Nov;11(11):2420-6. Japanese. PubMed PMID: 6497400.

205: Fujimoto S, Tashiro T, Ogawa M. Antitumor activity and toxicity of methyl 6-[3-(2-chloroethyl)- 3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside in experimental animals. Gann. 1984 Oct;75(10):937-46. PubMed PMID: 6510639.

206: Sekido S, Ninomiya K, Araki T, Ueno M, Kinbara M. [Experimental studies on oral administration of nitrosourea anti-tumor agent, MCNU]. Gan To Kagaku Ryoho. 1984 Jul;11(7):1492-500. Japanese. PubMed PMID: 6234861.

207: Ninomiya K, Sekido S, Araki T. [Effect of combination chemotherapy of nitrosourea MCNU with various anti-tumor agents]. Gan To Kagaku Ryoho. 1984 Jun;11(6):1315-23. Japanese. PubMed PMID: 6428326.

208: Wakabayashi T, Yoshida J, Inoue I, Kageyama N, Nagata M, Kanzaki M. [MCNU effectiveness on brain tumor. Part I: Antitumor activity in vitro on human glioma and neuroblastoma cell lines]. Gan To Kagaku Ryoho. 1984 May;11(5):1098-106. Japanese. PubMed PMID: 6586113.

209: Kanamaru A, Nagai K, Fujita S, Masaoka T, Takubo T, Kitani T, Taniguchi N, Horiuchi A, Tsubaki K, Kawagoe H, Hirata M, Yonezawa T, Tsubakio T, Yasunaga K, Okamoto Y, Fujitake H, Ohkubo A. [Phase I study on oral administration of methyl-6-[[[(2-chloroethyl) nitrosoamino] carbonyl] amino]-6-deoxy-alpha-D-glucopyranoside (MCNU)]. Gan To Kagaku Ryoho. 1983 Aug;10(8):1831-7. Japanese. PubMed PMID: 6882006.

210: Furue H, Kako M, Mugitani H, Fuse K, Hirota F, Sakamoto K, Takahashi T, Ezaki M, Yamada K, Suminaga M, Kaise R. [Phase II clinical trial of MCNU]. Gan To Kagaku Ryoho. 1983 Jul;10(7):1679-83. Japanese. PubMed PMID: 6870310.

211: Masaoka T, Kimura K, Miyazaki T, Sakurada K, Saitoh H, Morioka M, Fujimoto N, Musashi M, Wakui A, Yokoyama M, Kanamaru R, Oguro M, Takagi T, Konda C, Saitoh T, Nakao I, Harashima S, Ohhashi Y, Sakai Y, Sasaki T, Ohno R, Katoh Y, Yamada K, Hirota Y, Takada T, Hoshino A, Ohara K, Kamiya O, Kojima T, Nagata K, Nakamura T, Sasada M, Yonezawa T, Tsubakio T, Kanayama Y, Kitani T, Taniguchi N, Yasunaga K, Okamoto Y, Fujitake H, Ohkubo A, Horiuchi A, Tsubaki K, Takubo T, Shibata H, Kawagoe H, Hirata M, Matsubuchi T, Nagai K, Fujita S. [Phase II study with methyl-6[[[2-chloroethyl) nitrosoamino] carbonyl] amino]-6-deoxy-alpha-D-glucopyranoside (MCNU) in hematological malignancies]. Gan To Kagaku Ryoho. 1983 Jun;10(6):1518-23. Japanese. PubMed PMID: 6347081.

212: Kato T, Ota K. [Comparative effect of administration schedules on the antitumor activities of 3 water-soluble nitrosoureas, ACNU, GANU and MCNU against L1210 leukemia]. Gan To Kagaku Ryoho. 1983 May;10(5):1354-62. Japanese. PubMed PMID: 6223585.

213: Wakui A. [Cancer chemotherapy with special reference to pharmacokinetics of nitrosoureas]. Gan To Kagaku Ryoho. 1982 Aug;9(8):1327-38. Review. Japanese. PubMed PMID: 6223595.

214: Nomura K, Shibui S, Watanabe T. [Application of flow cytometry to chemotherapy of malignant brain tumor]. Gan To Kagaku Ryoho. 1982 Jul;9(7):1151-63. Japanese. PubMed PMID: 6191709.

215: Katoh T, Ishige H, Takamizawa H, Tokita H, Tanaka N. [Effects of various agents on human choriocarcinoma transplanted to nude mice]. Gan To Kagaku Ryoho. 1982 May;9(5):843-8. Japanese. PubMed PMID: 6892200.

216: Tashiro T, Inaba M, Sakurai Y. Reduction of lethal toxicity of chloroethylnitrosoureas by sugar alcohols without loss of antitumor activity. Cancer Chemother Pharmacol. 1982;8(2):183-8. PubMed PMID: 6809355.

217: Fujimoto S, Ogawa M. A new nitrosourea derivative TA-077, 1-(2-chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1-nitrosourea. I. Comparative study on antitumor activity. Cancer Chemother Pharmacol. 1982;9(3):134-9. PubMed PMID: 6218931.

218: Harada K, Kiya K, Okamoto H, Uozumi T. [Comparative studies on anti-tumor effects of nitrosoureas, ACNU and MCNU, on experimental brain tumors (author's transl)]. Neurol Med Chir (Tokyo). 1981 Oct;21(10):1017-23. Japanese. PubMed PMID: 6172720.

219: Ogawa M, Fujimoto S. Current status of nitrosoureas under development in Japan. Recent Results Cancer Res. 1981;76:115-24. Review. PubMed PMID: 6453413.

220: Ogawa M. Phase I study of GANU and MCNU. Cancer Treat Rev. 1980 Dec;7(4):197-203. PubMed PMID: 6452200.

221: Inoue K, Fujimoto S, Ogawa M. Comparison of antitumor activities of nitrosourea derivatives against mammary breast carcinoma (MX-1) in nude mice. Gann. 1980 Oct;71(5):686-91. PubMed PMID: 7227717.

222: Tsukagoshi S. Review of experimental studies on nitrosourea derivatives in Japan. Recent Results Cancer Res. 1980;70:107-17. PubMed PMID: 7355242.

223: Sekido S, Ninomiya K, Iwasaki M. Biologic activity of MCNU: a new antitumor agent. Cancer Treat Rep. 1979 Jun;63(6):961-70. PubMed PMID: 466655.

224: Sakurai Y. Synthetic analogs of antitumor drugs under development in Japan. Recent Results Cancer Res. 1978;63:272-81. PubMed PMID: 705011.