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MedKoo product information:
Pentostatin
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MedKoo Code#: 100720
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Name:
Pentostatin
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CAS#: 53910-25-1
Synonym: 2'-deoxycoformycin;
co-vidarabine; deoxycoformycin; pentostatine. US
brand name: Nipent. Abbreviation: DCF. Code names:
CI-825; PD-81565. Chemical structure name:
(R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
IUPAC/Chemical name:
(R)-3-((2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
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Chemical structure:
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Theoretical analysis
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Chemical Formula: C11H16N4O4
Exact Mass: 268.11716
Molecular Weight: 268.27
m/z: 268.11716 (100.0%), 269.12051 (11.9%),
269.11419 (1.5%)
Elemental Analysis: C, 49.25; H, 6.01; N,
20.88; O, 23.86
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Availability and price:
This agent is
available. For quotation, question, and order, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer significant discount
for larger quantity order.
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Quality control
data:
Product will be shipped with
supporting analytical data.
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Information about this agent
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Pentostatin is a purine nucleotide analogue antibiotic isolated from
the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin,
pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme
essential to purine metabolism; ADA activity is greatest in cells of
the lymphoid system with T-cells having higher activity than B-cells
and T-cell malignancies higher ADA activity than B-cell
malignancies. Pentostatin inhibition of ADA appears to result in
elevated intracellular levels of dATP which may block DNA synthesis
through the inhibition of ribonucleotide reductase. This agent may
also inhibit RNA synthesis and may selectively deplete CD26+
lymphocytes. Check for
active clinical trials or
closed clinical trials using this agent. (NCI
Thesaurus).
Pentostatin is used to treat hairy cell leukemia. It is given by
intravenous infusion once every two weeks for three to six months.
Additionally, pentostatin has been used to treat steroid-refractory
acute and chronic graft-versus-host disease. Pentostatin is also
used in CLL patients who have relapsed.
1: Malfuson JV, Fagot T, Konopacki J,
Souleau B, Cremades S, de Revel T. Which role for rituximab in hairy
cell leukemia? Reflections on six cases. Acta Haematol.
2010;123(2):110-6. Epub 2009 Dec 24. Review. PubMed PMID: 20051682.
2: Dasanu CA, Ichim TE, Alexandrescu DT. Inherent and iatrogenic immune
defects in hairy cell leukemia: revisited. Expert Opin Drug Saf. 2010
Jan;9(1):55-64. Review. PubMed PMID: 20001754.
3: Dasanu CA, Alexandrescu DT. Risk of additional cancers in untreated
and treated hairy cell leukemia patients. Expert Opin Pharmacother. 2010
Jan;11(1):41-50. Review. PubMed PMID: 20001428.
4: Kreitman RJ, Fitzgerald DJ, Pastan I. Approach to the patient after
relapse of hairy cell leukemia. Leuk Lymphoma. 2009 Oct;50 Suppl 1:32-7.
Review. PubMed PMID: 19814696.
5: Grever MR, Zinzani PL. Long-term follow-up studies in hairy cell
leukemia. Leuk Lymphoma. 2009 Oct;50 Suppl 1:23-6. Review. PubMed PMID:
19814694.
6: Lauria F, Forconi F. Combination therapies to improve the long-term
outcome in hairy cell leukemia. Leuk Lymphoma. 2009 Oct;50 Suppl
1:18-22. Review. PubMed PMID: 19814693.
7: Huynh E, Sigal D, Saven A. Cladribine in the treatment of hairy cell
leukemia: initial and subsequent results. Leuk Lymphoma. 2009 Oct;50
Suppl 1:12-7. Review. PubMed PMID: 19814692.
8: Dearden CE. T-cell prolymphocytic leukemia. Clin Lymphoma Myeloma.
2009;9 Suppl 3:S239-43. Review. PubMed PMID: 19778847.
9: Lamanna N, Kay NE. Pentostatin treatment combinations in chronic
lymphocytic leukemia. Clin Adv Hematol Oncol. 2009 Jun;7(6):386-92.
Review. PubMed PMID: 19606074.
10: Wolff D, Steiner B, Hildebrandt G, Edinger M, Holler E.
Pharmaceutical and cellular strategies in prophylaxis and treatment of
graft-versus-host disease. Curr Pharm Des. 2009;15(17):1974-97. Review.
PubMed PMID: 19519437.
11: Robak T, Korycka A, Lech-Maranda E, Robak P. Current status of older
and new purine nucleoside analogues in the treatment of
lymphoproliferative diseases. Molecules. 2009 Mar 23;14(3):1183-226.
Review. PubMed PMID: 19325518.
12: Cannon T, Mobarek D, Wegge J, Tabbara IA. Hairy cell leukemia:
current concepts. Cancer Invest. 2008 Oct;26(8):860-5. Review. PubMed
PMID: 18798068.
13: Sauter C, Lamanna N, Weiss MA. Pentostatin in chronic lymphocytic
leukemia. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1217-22. Review.
PubMed PMID: 18721115.
14: Bolaños-Meade J, Vogelsang GB. Chronic graft-versus-host disease.
Curr Pharm Des. 2008;14(20):1974-86. Review. PubMed PMID: 18691108.
15: Christian BA, Lin TS. Antibody therapy for chronic lymphocytic
leukemia. Semin Hematol. 2008 Apr;45(2):95-103. Review. PubMed PMID:
18381104; PubMed Central PMCID: PMC2390995.
16: Fanta PT, Saven A. Hairy cell leukemia. Cancer Treat Res.
2008;142:193-209. Review. PubMed PMID: 18283787.
17: Robak T. Recent progress in the management of chronic lymphocytic
leukemia. Cancer Treat Rev. 2007 Dec;33(8):710-28. Epub 2007 Sep 27.
Review. PubMed PMID: 17904294.
18: Kim SS. Treatment options in steroid-refractory acute
graft-versus-host disease following hematopoietic stem cell
transplantation. Ann Pharmacother. 2007 Sep;41(9):1436-44. Epub 2007 Aug
7. Review. PubMed PMID: 17684033.
19: Robak T, Robak P. Current treatment options in prolymphocytic
leukemia. Med Sci Monit. 2007 Apr;13(4):RA69-80. Review. PubMed PMID:
17392661.
20: Ferrara JL. Novel strategies for the treatment and diagnosis of
graft-versus-host-disease. Best Pract Res Clin Haematol. 2007
Mar;20(1):91-7. Review. PubMed PMID: 17336259.
21: Kay NE, Rai KR, O'Brien S. Chronic lymphocytic leukemia: current and
emerging treatment approaches. Clin Adv Hematol Oncol. 2006 Nov;4(11
Suppl 22):1-10; quiz 11-2. Review. PubMed PMID: 17143256.
22: Grever MR. Pentostatin: impact on outcome in hairy cell leukemia.
Hematol Oncol Clin North Am. 2006 Oct;20(5):1099-108. Review. PubMed
PMID: 16990110.
23: Dearden C, Else M. Hairy cell leukemia. Curr Oncol Rep. 2006
Sep;8(5):337-42. Review. PubMed PMID: 16953542.
24: Blijlevens NM, Donnelly JP, de Pauw BE. Microbiologic consequences
of new approaches to managing hematologic malignancies. Rev Clin Exp
Hematol. 2005 Dec;9(2):E2. Review. PubMed PMID: 16864116.
25: Steurer M, Pall G, Richards S, Schwarzer G, Bohlius J, Greil R.
Purine antagonists for chronic lymphocytic leukaemia. Cochrane Database
Syst Rev. 2006 Jul 19;3:CD004270. Review. PubMed PMID: 16856041.
26: Osuji N, Matutes E, Tjonnfjord G, Grech H, Del Giudice I,
Wotherspoon A, Swansbury JG, Catovsky D. T-cell large granular
lymphocyte leukemia: A report on the treatment of 29 patients and a
review of the literature. Cancer. 2006 Aug 1;107(3):570-8. Review.
Erratum in: Cancer. 2006 Dec 1;107(11):2744. PubMed PMID: 16795070.
27: Steurer M, Pall G, Richards S, Schwarzer G, Bohlius J, Greil R;
Cochrane Haematologic Malignancies Group. Single-agent purine analogues
for the treatment of chronic lymphocytic leukaemia: a systematic review
and meta-analysis. Cancer Treat Rev. 2006 Aug;32(5):377-89. Epub 2006
Jun 21. Review. PubMed PMID: 16793209.
28: Pérez-Simón JA, Sánchez-Abarca I, Díez-Campelo M, Caballero D, San
Miguel J. Chronic graft-versus-host disease: Pathogenesis and clinical
management. Drugs. 2006;66(8):1041-57. Review. PubMed PMID: 16789791.
29: Robak T. Current treatment options in hairy cell leukemia and hairy
cell leukemia variant. Cancer Treat Rev. 2006 Aug;32(5):365-76. Epub
2006 Jun 15. Review. PubMed PMID: 16781083.
30: Ho AD, Hensel M. Pentostatin and purine analogs for indolent
lymphoid malignancies. Future Oncol. 2006 Apr;2(2):169-83. Review.
PubMed PMID: 16563086.
31: Kay NE. Purine analogue-based chemotherapy regimens for patients
with previously untreated B-chronic lymphocytic leukemia. Semin Hematol.
2006 Apr;43(2 Suppl 2):S50-4. Review. PubMed PMID: 16549115.
32: Lamanna N, Weiss MA. Purine analogue-based chemotherapy regimens for
second-line therapy in patients with chronic lymphocytic leukemia. Semin
Hematol. 2006 Apr;43(2 Suppl 2):S44-9. Review. PubMed PMID: 16549114.
33: Foss FM. The role of purine analogues in low-intensity regimens with
allogeneic hematopoietic stem cell transplantation. Semin Hematol. 2006
Apr;43(2 Suppl 2):S35-43. Review. PubMed PMID: 16549113.
34: Kurzrock R, Ravandi F. Purine analogues in advanced T-cell lymphoid
malignancies. Semin Hematol. 2006 Apr;43(2 Suppl 2):S27-34. Review.
PubMed PMID: 16549112.
35: Dearden CE. Role of single-agent purine analogues in therapy of
peripheral T-cell lymphomas. Semin Hematol. 2006 Apr;43(2 Suppl
2):S22-6. Review. PubMed PMID: 16549111.
36: Ho AD, Hensel M. Pentostatin for the treatment of indolent
lymphoproliferative disorders. Semin Hematol. 2006 Apr;43(2 Suppl
2):S2-10. Review. PubMed PMID: 16549110.
37: Bolaños-Meade J. Update on the management of acute graft-versus-host
disease. Curr Opin Oncol. 2006 Mar;18(2):120-5. Review. PubMed PMID:
16462179.
38: Robak T. Therapy of chronic lymphocytic leukaemia with purine
nucleoside analogues: facts and controversies. Drugs Aging.
2005;22(12):983-1012. Review. PubMed PMID: 16363884.
39: Hotta T. Treatment of T-Cell lymphoma. Hematology. 2005;10 Suppl
1:193-6. Review. PubMed PMID: 16188671.
40: Robak T, Korycka A, Kasznicki M, Wrzesien-Kus A, Smolewski P. Purine
nucleoside analogues for the treatment of hematological malignancies:
pharmacology and clinical applications. Curr Cancer Drug Targets. 2005
Sep;5(6):421-44. Review. PubMed PMID: 16178817.
41: Lamanna N. Advances in the treatment of chronic lymphocytic
leukemia. Curr Oncol Rep. 2005 Sep;7(5):333-8. Review. PubMed PMID:
16091193.
42: Absi A, Hsi E, Kalaycio M. Prolymphocytic leukemia. Curr Treat
Options Oncol. 2005 May;6(3):197-208. Review. PubMed PMID: 15869731.
43: Tallman MS, Zakarija A. Hairy cell leukemia: survival and relapse.
Long-term follow-up of purine analog-based therapy and approach for
relapsed disease. Transfus Apher Sci. 2005 Feb;32(1):99-103. Review.
PubMed PMID: 15737878.
44: Bolaños-Meade J, Vogelsang GB. Novel strategies for
steroid-refractory acute graft-versus-host disease. Curr Opin Hematol.
2005 Jan;12(1):40-4. Review. PubMed PMID: 15604890.
45: Higman M, Vogelsang GB, Chen A. Pentostatin - pharmacology,
immunology, and clinical effects in graft-versus-host disease. Expert
Opin Pharmacother. 2004 Dec;5(12):2605-13. Review. PubMed PMID:
15571477.
46: Lamanna N, Weiss M. Purine analogs in leukemia. Adv Pharmacol.
2004;51:107-25. Review. PubMed PMID: 15464907.
47: Lee SS, Robinson MR, Morris JC, Mirtsching BC, Shen D, Chan CC.
Conjunctival involvement with T-cell prolymphocytic leukemia: report of
a case and review of the literature. Surv Ophthalmol. 2004
Sep-Oct;49(5):525-36. Review. PubMed PMID: 15325197.
48: Foss F. Overview of cutaneous T-cell lymphoma: prognostic factors
and novel therapeutic approaches. Leuk Lymphoma. 2003;44 Suppl 3:S55-61.
Review. PubMed PMID: 15202526.
49: Lundin J, Osterborg A. Therapy for mycosis fungoides. Curr Treat
Options Oncol. 2004 Jun;5(3):203-14. Review. PubMed PMID: 15115649.
50: Robak T. Monoclonal antibodies in the treatment of chronic lymphoid
leukemias. Leuk Lymphoma. 2004 Feb;45(2):205-19. Review. PubMed PMID:
15101704.
51: Nabhan C, Gartenhaus RB, Tallman MS. Purine nucleoside analogues and
combination therapies in B-cell chronic lymphocytic leukemia: dawn of a
new era. Leuk Res. 2004 May;28(5):429-42. Review. PubMed PMID: 15068894.
52: Dillman RO. Pentostatin (Nipent) in the treatment of chronic
lymphocyte leukemia and hairy cell leukemia. Expert Rev Anticancer Ther.
2004 Feb;4(1):27-36. Review. PubMed PMID: 14748654.
53: Dearden CE, Foss FM. Peripheral T-cell lymphomas: diagnosis and
management. Hematol Oncol Clin North Am. 2003 Dec;17(6):1351-66. Review.
PubMed PMID: 14710889.
54: Jacobsohn DA. Emerging therapies for graft-versus-host disease.
Expert Opin Emerg Drugs. 2003 Nov;8(2):323-38. Review. PubMed PMID:
14661992.
55: Goodman GR, Bethel KJ, Saven A. Hairy cell leukemia: an update. Curr
Opin Hematol. 2003 Jul;10(4):258-66. Review. PubMed PMID: 12799530.
56: Pettitt AR. Mechanism of action of purine analogues in chronic
lymphocytic leukaemia. Br J Haematol. 2003 Jun;121(5):692-702. Review.
PubMed PMID: 12780783.
57: Robak T. Purine nucleoside analogues in the treatment of myleoid
leukemias. Leuk Lymphoma. 2003 Mar;44(3):391-409. Review. PubMed PMID:
12688309.
58: Goodman GR, Beutler E, Saven A. Cladribine in the treatment of
hairy-cell leukaemia. Best Pract Res Clin Haematol. 2003
Mar;16(1):101-16. Review. PubMed PMID: 12670469.
59: Grever MR, Doan CA, Kraut EH. Pentostatin in the treatment of
hairy-cell leukemia. Best Pract Res Clin Haematol. 2003 Mar;16(1):91-9.
Review. PubMed PMID: 12670468.
60: Ahmed S, Rai KR. Interferon in the treatment of hairy-cell leukemia.
Best Pract Res Clin Haematol. 2003 Mar;16(1):69-81. Review. PubMed PMID:
12670466.
61: Matutes E, Wotherspoon A, Catovsky D. The variant form of hairy-cell
leukaemia. Best Pract Res Clin Haematol. 2003 Mar;16(1):41-56. Review.
PubMed PMID: 12670464.
62: Cao TM, Coutre SE. T-cell prolymphocytic leukemia: update and focus
on alemtuzumab (Campath-1H). Hematology. 2003 Feb;8(1):1-6. Review.
PubMed PMID: 12623420.
63: Sato K, Dang NH. CD26: a novel treatment target for T-cell lymphoid
malignancies? (Review). Int J Oncol. 2003 Mar;22(3):481-97. Review.
PubMed PMID: 12579300.
64: Mey U, Strehl J, Gorschlüter M, Ziske C, Glasmacher A, Pralle H,
Schmidt-Wolf I. Advances in the treatment of hairy-cell leukaemia.
Lancet Oncol. 2003 Feb;4(2):86-94. Review. PubMed PMID: 12573350.
65: Zinzani PL. Non-Hodgkin's lymphoma: the evolving role of purine
analogues. Best Pract Res Clin Haematol. 2002 Sep;15(3):505-16. Review.
PubMed PMID: 12468402.
66: Hosmane RS. Ring-expanded ("Fat") nucleosides as broad-spectrum
anticancer and antiviral agents. Curr Top Med Chem. 2002
Oct;2(10):1093-109. Review. PubMed PMID: 12173969.
67: Todd SA, Morris TC, Alexander HD. Myelodysplasia terminating in
acute myeloid leukemia in a hairy cell leukemia patient treated with
2-deoxycoformycin. Leuk Lymphoma. 2002 Jun;43(6):1343-4. Review. PubMed
PMID: 12153007.
68: Giné E, Bosch F, Villamor N, Rozman M, Colomer D, López-Guillermo A,
Campo E, Montserrat E. Simultaneous diagnosis of hairy cell leukemia and
chronic lymphocytic leukemia/small lymphocytic lymphoma: a frequent
association? Leukemia. 2002 Aug;16(8):1454-9. Review. PubMed PMID:
12145685.
69: Itälä M, Remes K. [Nucleoside analogues--new drugs for the treatment
of lymphatic cancers]. Duodecim. 2001;117(2):162-9. Review. Finnish.
PubMed PMID: 12092367.
70: Savoie L, Johnston JB. Hairy cell leukemia. Curr Treat Options Oncol.
2001 Jun;2(3):217-24. Review. PubMed PMID: 12057121.
71: Apisarnthanarax N, Talpur R, Duvic M. Treatment of cutaneous T cell
lymphoma: current status and future directions. Am J Clin Dermatol.
2002;3(3):193-215. Review. PubMed PMID: 11978140.
72: Samonis G, Kontoyiannis DP. Infectious complications of purine
analog therapy. Curr Opin Infect Dis. 2001 Aug;14(4):409-13. Review.
PubMed PMID: 11964857.
73: Bashey A. Immunosuppression with limited toxicity: the
characteristics of nucleoside analogs and anti-lymphocyte antibodies
used in non-myeloablative hematopoietic cell transplantation. Cancer
Treat Res. 2002;110:39-49. Review. PubMed PMID: 11908199.
74: Owen RG. Treatment options in Waldenström's macroglobulinaemia: the
role of the purine analogues. Expert Opin Pharmacother. 2001
Jun;2(6):945-52. Review. PubMed PMID: 11585010.
75: Johnson SA. Nucleoside analogues in the treatment of haematological
malignancies. Expert Opin Pharmacother. 2001 Jun;2(6):929-43. Review.
PubMed PMID: 11585009.
76: Andrey J, Saven A. Therapeutic advances in the treatment of hairy
cell leukemia. Leuk Res. 2001 May;25(5):361-8. Review. PubMed PMID:
11301103.
77: Weiss MA. Novel treatment strategies in chronic lymphocytic
leukemia. Curr Oncol Rep. 2001 May;3(3):217-22. Review. PubMed PMID:
11296131.
78: Kintzel PE. Anticancer drug-induced kidney disorders. Drug Saf. 2001
Jan;24(1):19-38. Review. PubMed PMID: 11219485.
79: Au WY, Kwong YL, Ma SK, Mak YK, Wong KF, Lei KI, Ng MH, Chan JC, Lin
SY, Lee KK, Liang R. Hairy cell leukemia in Hong Kong Chinese: a 12-year
retrospective survey. Hematol Oncol. 2000 Dec;18(4):155-159. Review.
PubMed PMID: 11135356.
80: Johnson SA, Thomas W. Therapeutic potential of purine analogue
combinations in the treatment of lymphoid malignancies. Hematol Oncol.
2000 Dec;18(4):141-153. Review. PubMed PMID: 11135355.
81: Arai S, Vogelsang GB. Management of graft-versus-host disease. Blood
Rev. 2000 Dec;14(4):190-204. Review. PubMed PMID: 11124107.
82: Honma Y, Niitsu N. Vidarabine and 2-deoxycoformycin as antileukemic
agents against monocytic leukemia. Leuk Lymphoma. 2000
Sep;39(1-2):57-66. Review. PubMed PMID: 10975384.
83: Johnson SA. Clinical pharmacokinetics of nucleoside analogues: focus
on haematological malignancies. Clin Pharmacokinet. 2000 Jul;39(1):5-26.
Review. PubMed PMID: 10926348.
84: Foss FM. Combination therapy with purine nucleoside analogs.
Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):31-5. Review. PubMed
PMID: 10887642.
85: Verstovsek S, Cabanillas F, Dang NH. CD26 in T-cell lymphomas: a
potential clinical role? Oncology (Williston Park). 2000 Jun;14(6 Suppl
2):17-23. Review. PubMed PMID: 10887640.
86: Cabanillas F. Purine nucleoside analogs in indolent non-Hodgkin's
lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
Review. PubMed PMID: 10887639.
87: Margolis J, Vogelsang G. An old drug for a new disease: pentostatin
(Nipent) in acute graft-versus-host disease. Semin Oncol. 2000 Apr;27(2
Suppl 5):72-7. Review. PubMed PMID: 10877057.
88: Waselenko JK, Grever MR, Beer M, Lucas MA, Byrd JC. Pentostatin (Nipent)
and chlorambucil with granulocyte-macrophage colony-stimulating factor
support for patients with previously untreated, treated, and fludarabine-refractory
B-cell chronic lymphocytic leukemia. Semin Oncol. 2000 Apr;27(2 Suppl
5):44-51. Review. PubMed PMID: 10877052.
89: Margolis J, Grever MR. Pentostatin (Nipent): a review of potential
toxicity and its management. Semin Oncol. 2000 Apr;27(2 Suppl 5):9-14.
Review. PubMed PMID: 10877045.
90: Heald P. Future directions for pentostatin (Nipent) usage in
dermatology. Semin Oncol. 2000 Apr;27(2 Suppl 5):3-8. Review. PubMed
PMID: 10877044.
91: Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents:
incidence, treatment and prevention. Drug Saf. 2000 Apr;22(4):263-302.
Review. PubMed PMID: 10789823.
92: Vogelsang GB. Advances in the treatment of graft-versus-host
disease. Leukemia. 2000 Mar;14(3):509-10. Review. PubMed PMID: 10720152.
93: Maloisel F, Andrès E, Troussard X, Herbrecht R, Dufour P.
[Therapeutic aspects in the management of hairy cell leukemia]. Presse
Med. 1999 Nov 6;28(34):1887-94. Review. French. PubMed PMID: 10587727.
94: Weitzman S, Wayne AS, Arceci R, Lipton JM, Whitlock JA. Nucleoside
analogues in the therapy of Langerhans cell histiocytosis: a survey of
members of the histiocyte society and review of the literature. Med
Pediatr Oncol. 1999 Nov;33(5):476-81. Review. PubMed PMID: 10531572.
95: Niitsu N, Honma Y. Adenosine analogs as possible
differentiation-inducing agents against acute myeloid leukemia. Leuk
Lymphoma. 1999 Jul;34(3-4):261-71. Review. PubMed PMID: 10439363.
96: Tallman MS, Peterson LC, Hakimian D, Gillis S, Polliack A. Treatment
of hairy-cell leukemia: current views. Semin Hematol. 1999
Apr;36(2):155-63. Review. PubMed PMID: 10319384.
97: Rucińska M, Machaczka M, Załuska A, Skotnicki AB. [Hairy cell
leukemia--a potentially curable malignancy. Selected aspects of purine
analog therapy]. Przegl Lek. 1998;55(7-8):400-6. Review. Polish. PubMed
PMID: 10021885.
98: Foss FM, Kuzel TM. Novel treatment approaches for cutaneous T-cell
lymphoma. Cancer Treat Res. 1999;99:227-40. Review. PubMed PMID:
9891869.
99: Ohnishi K, Ohno R. [New antitumor drugs for non-Hodgkin's lymphoma].
Gan To Kagaku Ryoho. 1998 Dec;25(14):2223-8. Review. Japanese. PubMed
PMID: 9881079.
100: Troussard X, Maloisel F, Flandrin G. Hairy cell leukemia. What is
new forty years after the first description? Hematol Cell Ther. 1998
Aug;40(4):139-48. Review. PubMed PMID: 9766918.
101: Cheson BD. Therapy for previously untreated chronic lymphocytic
leukemia: a reevaluation. Semin Hematol. 1998 Jul;35(3 Suppl 3):14-21.
Review. PubMed PMID: 9685175.
102: Polliack A. Hairy cell leukemia and allied chronic lymphoid
leukemias: current knowledge and new therapeutic options. Leuk Lymphoma.
1997 Dec;26 Suppl 1:41-51. Review. PubMed PMID: 9570679.
103: Bergmann L. Present status of purine analogs in the therapy of
chronic lymphocytic leukemias. Leukemia. 1997 Apr;11 Suppl 2:S29-34.
Review. PubMed PMID: 9178835.
104: Cheson BD. Perspectives on purine analogues. Hematol Cell Ther.
1996 Dec;38 Suppl 2:S109-16. Review. PubMed PMID: 9137964.
105: Catovsky D. Clinical experience with 2'-deoxycoformycin. Hematol
Cell Ther. 1996 Dec;38 Suppl 2:S103-7. Review. PubMed PMID: 9137963.
106: Dighiero G. Adverse and beneficial immunological effects of purine
nucleoside analogues. Hematol Cell Ther. 1996 Dec;38 Suppl 2:S75-81.
Review. PubMed PMID: 9137960.
107: Plunkett W, Gandhi V. Pharmacology of purine nucleoside analogues.
Hematol Cell Ther. 1996 Dec;38 Suppl 2:S67-74. Review. PubMed PMID:
9137959.
108: Adam Z, Vorlícek J, Hejlová N. [Treatment of chronic lymphatic
leukemia]. Vnitr Lek. 1996 Aug;42(8):573-8. Review. Czech. PubMed PMID:
8967031.
109: Fabianowska-Majewska K, Wyczechowska D. 2-Chloro-2'-deoxyadenosine
(2CdA) biochemical aspects of antileukemic efficacy. Acta Pol Pharm.
1996 Jul-Aug;53(4):231-9. Review. PubMed PMID: 9415193.
110: Spiers AS. Deoxycoformycin (pentostatin): clinical pharmacology,
role in the chemotherapy of cancer, and use in other diseases.
Haematologia (Budap). 1996;27(2):55-84. Review. PubMed PMID: 14651224.
111: Saven A, Piro LD. 2-Chlorodeoxyadenosine treatment of lymphoma.
Cancer Treat Res. 1996;85:15-26. Review. PubMed PMID: 9043772.
112: Johnson SA. Purine analogues in the management of
lymphoproliferative diseases. Clin Oncol (R Coll Radiol).
1996;8(5):289-96. Review. PubMed PMID: 8934048.
113: Volkova MA, Lepkov SV, Nechipaĭ AN, Probatova NA, Tupitsin NN,
Sholokhova EN, Lebedeva NV, Frenkel' MA. [Hairy cell leukemia with
specific omental involvement]. Ter Arkh. 1996;68(7):79-82. Review.
Russian. PubMed PMID: 8928079.
114: Paitel JF, Guerci A, Lederlin P. [Hairy cell leukemia: therapeutic
approaches]. Rev Med Interne. 1996;17(5):399-406. Review. French. PubMed
PMID: 8763100.
115: Tallman MS, Hakimian D. Purine nucleoside analogs: emerging roles
in indolent lymphoproliferative disorders. Blood. 1995 Oct
1;86(7):2463-74. Review. Erratum in: Blood 1996 Mar 1;87(5):2093. PubMed
PMID: 7670093.
116: Hamblin TJ. Chronic lymphocytic leukaemia--new drugs and
management. J R Coll Physicians Lond. 1995 Sep-Oct;29(5):419-21. Review.
PubMed PMID: 8847686.
117: Cheson BD. Infectious and immunosuppressive complications of purine
analog therapy. J Clin Oncol. 1995 Sep;13(9):2431-48. Review. PubMed
PMID: 7666104.
118: Gollard R, Lee TC, Piro LD, Saven A. The optimal management of
hairy cell leukaemia. Drugs. 1995 Jun;49(6):921-31. Review. PubMed PMID:
7543840.
119: Pott-Hoeck C, Hiddemann W. Purine analogs in the treatment of
low-grade lymphomas and chronic lymphocytic leukemias. Ann Oncol. 1995
May;6(5):421-33. Review. PubMed PMID: 7669706.
120: Lazarus HM. Bone marrow transplantation in low-grade non-Hodgkin's
lymphoma. Leuk Lymphoma. 1995 Apr;17(3-4):199-210. Review. PubMed PMID:
8580788.
121: Molica S, De Rossi G, Luciani M, Levato D. Prognostic features and
therapeutical approaches in B-cell chronic lymphocytic leukemia: an
update. Haematologica. 1995 Mar-Apr;80(2):176-93. Review. PubMed PMID:
7628755.
122: Pawelski S. [Hairy cell leukemia and its treatment with
2-chlorodeoxyadenosine (2-CdA)]. Acta Haematol Pol. 1995;26(2):139-43.
Review. Polish. PubMed PMID: 7653218.
123: Taguchi H. [Treatment of adult T-cell leukemia]. Gan To Kagaku
Ryoho. 1995 Jan;22(1):16-22. Review. Japanese. PubMed PMID: 7529979.
124: Cheson BD, Vena DA, Foss FM, Sorensen JM. Neurotoxicity of purine
analogs: a review. J Clin Oncol. 1994 Oct;12(10):2216-28. Review. PubMed
PMID: 7931492.
125: Cheson BD. Chronic lymphocytic leukemia and hairy-cell leukemia.
Curr Opin Hematol. 1994 Jul;1(4):268-77. Review. PubMed PMID: 9371293.
126: Saven A, Piro L. Newer purine analogues for the treatment of
hairy-cell leukemia. N Engl J Med. 1994 Mar 10;330(10):691-7. Review.
Erratum in: N Engl J Med 1994 Apr 28;330(17):1247. PubMed PMID: 7906385.
127: Dillman RO. A new chemotherapeutic agent: deoxycoformycin (pentostatin).
Semin Hematol. 1994 Jan;31(1):16-27. Review. PubMed PMID: 8122134.
128: Volkova MA, Lepkov SV, Frenkel' MA, Lebedeva NB, Tupitsyn NN.
[Hairy-cell leukemia (a review of the literature and the authors' own
data)]. Ter Arkh. 1994;66(7):43-9. Review. Russian. PubMed PMID:
7985128.
129: Gallagher KP, McClanahan TB, Martin BJ, Saganek LJ, Ignasiak DP,
Mertz TE, Van Wylen DG, Vinten-Johansen J. Does adenosine deaminase
inhibition protect ischemic myocardium? Adv Exp Med Biol.
1994;370:291-4. Review. PubMed PMID: 7660911.
130: Dighiero G. Potential immunological action of purine nucleoside
analogues. Drugs. 1994;47 Suppl 6:57-62. Review. PubMed PMID: 7525190.
131: Juliusson G. Immunological and genetic abnormalities in chronic
lymphocytic leukaemia. Impact of the purine analogues. Drugs. 1994;47
Suppl 6:19-29. Review. PubMed PMID: 7525186.
132: Yamaguchi K, Takatsuki K. Adult T cell leukaemia-lymphoma.
Baillieres Clin Haematol. 1993 Dec;6(4):899-915. Review. PubMed PMID:
8038496.
133: Platanias LC, Golomb HM. Hairy cell leukaemia. Baillieres Clin
Haematol. 1993 Dec;6(4):887-98. Review. PubMed PMID: 7913637.
134: Saven A, Piro LD. The newer purine analogs. Significant therapeutic
advance in the management of lymphoid malignancies. Cancer. 1993 Dec
1;72(11 Suppl):3470-83. Review. PubMed PMID: 7902205.
135: Bryson HM, Sorkin EM. Cladribine. A review of its pharmacodynamic
and pharmacokinetic properties and therapeutic potential in
haematological malignancies. Drugs. 1993 Nov;46(5):872-94. Review.
PubMed PMID: 7507037.
136: Saven A. Comparative efficacy of the newer nucleosides (fludarabine,
2'-deoxycoformycin, and 2-chlorodeoxyadenosine) in the treatment of
indolent lymphoid malignancies. Semin Hematol. 1993 Oct;30(4 Suppl
6):31-3. Review. PubMed PMID: 7908757.
137: Brogden RN, Sorkin EM. Pentostatin. A review of its pharmacodynamic
and pharmacokinetic properties, and therapeutic potential in
lymphoproliferative disorders. Drugs. 1993 Oct;46(4):652-77. Review.
PubMed PMID: 7506651.
138: Jaiyesimi IA, Kantarjian HM, Estey EH. Advances in therapy for
hairy cell leukemia. A review. Cancer. 1993 Jul 1;72(1):5-16. Review.
PubMed PMID: 7685243.
139: Flandrin G. [Interferon-alpha in the treatment of hairy cell
leukemia. New perspectives]. Presse Med. 1993 Jan 2-16;22(1):9-12.
Review. French. PubMed PMID: 8097039.
140: Knobler R. [Interferon-alpha in cutaneous T-cell lymphoma]. Wien
Med Wochenschr. 1993;143(16-17):435-7. Review. German. PubMed PMID:
8273368.
141: Keating MJ, O'Brien S, Kantarjian H, Robertson LB, Koller C, Beran
M, Estey E. Nucleoside analogs in treatment of chronic lymphocytic
leukemia. Leuk Lymphoma. 1993;10 Suppl:139-45. Review. PubMed PMID:
8097653.
142: Cheson BD. Purine analogs in lymphoproliferative disorders. Leuk
Lymphoma. 1993;11 Suppl 2:153-9. Review. PubMed PMID: 7907252.
143: Saven A, Piro LD, Carrera CJ, Carson DA, Beutler E. Hairy cell
leukemia: new understanding of biology and treatment. Cancer Treat Res.
1993;64:15-34. Review. PubMed PMID: 7680875.
144: Klohs WD, Kraker AJ. Pentostatin: future directions. Pharmacol Rev.
1992 Dec;44(4):459-77. Review. PubMed PMID: 1480666.
145: Cheson BD. New antimetabolites in the treatment of human
malignancies. Semin Oncol. 1992 Dec;19(6):695-706. Review. PubMed PMID:
1361080.
146: Spielberger RT, Golomb HM. Hairy cell leukemia 1992. Leukemia. 1992
Nov;6 Suppl 4:142-6. Review. PubMed PMID: 1279327.
147: Weiss RB. Hypersensitivity reactions. Semin Oncol. 1992
Oct;19(5):458-77. Review. PubMed PMID: 1384149.
148: Kane BJ, Kuhn JG, Roush MK. Pentostatin: an adenosine deaminase
inhibitor for the treatment of hairy cell leukemia. Ann Pharmacother.
1992 Jul-Aug;26(7-8):939-47. Review. PubMed PMID: 1504408.
149: Tefferi A, Phyliky RL. A clinical update on chronic lymphocytic
leukemia. II. Critical analysis of current chemotherapeutic modalities.
Mayo Clin Proc. 1992 May;67(5):457-61. Review. PubMed PMID: 1405771.
150: Golomb HM, Ratain MJ, Mick R, Daly K. The treatment of hairy cell
leukemia: an update. Leukemia. 1992;6 Suppl 2:24-7. Review. PubMed PMID:
1349662.
151: Schiffer CA. Interferon studies in the treatment of patients with
leukemia. Semin Oncol. 1991 Oct;18(5 Suppl 7):1-6. Review. PubMed PMID:
1948122.
152: Cheson BD. New chemotherapeutic agents for non-Hodgkin's lymphomas.
Hematol Oncol Clin North Am. 1991 Oct;5(5):1027-51. Review. PubMed PMID:
1718938.
153: Kurzrock R, Talpaz M, Gutterman JU. Hairy cell leukaemia: review of
treatment. Br J Haematol. 1991 Oct;79 Suppl 1:17-20. Review. PubMed
PMID: 1718389.
154: Cheson BD. Chronic lymphocytic leukemia and hairy-cell leukemia.
Curr Opin Oncol. 1991 Feb;3(1):54-62. Review. PubMed PMID: 1710506.
155: Ho AD. Chemotherapy of chronic haematological malignancies.
Baillieres Clin Haematol. 1991 Jan;4(1):197-221. Review. PubMed PMID:
2039859.
156: Hinterberger W. [Chronic lymphatic leukemia]. Wien Med Wochenschr.
1991;141(9-10):198-201. Review. German. PubMed PMID: 1949842.
157: Belić A, Pejin D. [Present possibilities of treatment of chronic
B-cell lymphocytic leukemia]. Med Pregl. 1991;44(9-10):423-8. Review.
Croatian. PubMed PMID: 1806799.
158: Platanias LC, Ratain MJ. Hairy cell leukaemia: the role of alpha
interferon. Eur J Cancer. 1991;27 Suppl 4:S53-7. Review. PubMed PMID:
1799481.
159: Brown TD, Burris HA, Havlin KA, O'Rourke TJ, Rodriguez GI, Wall JG,
Weiss GR. New anticancer agents. Cancer Chemother Biol Response Modif.
1991;12:111-46. Review. PubMed PMID: 1718374.
160: Gribbin TE. New purine analogues for the treatment of chronic
B-cell malignancies. Henry Ford Hosp Med J. 1991;39(2):98-102. Review.
PubMed PMID: 1679757.
161: Lill MC, Golde DW. Treatment of hairy-cell leukemia. Blood Rev.
1990 Dec;4(4):238-44. Review. PubMed PMID: 1706207.
162: Ho AD, Pezzutto A, Hunstein W. [The therapy of hairy-cell
leukemia]. Dtsch Med Wochenschr. 1990 Oct 12;115(41):1556-9. Review.
German. PubMed PMID: 2209445.
163: Foon KA, Rai KR, Gale RP. Chronic lymphocytic leukemia: new
insights into biology and therapy. Ann Intern Med. 1990 Oct
1;113(7):525-39. Review. PubMed PMID: 2203293.
164: Dutcher JP, Salva KM, Wiernik PH. Successful treatment of hair cell
leukemia with 2'-deoxycoformycin after failure of interferons alpha or
beta. Am J Clin Oncol. 1990 Aug;13(4):290-3. Review. PubMed PMID:
2198792.
165: Treatment of hairy cell leukaemia. Lancet. 1990 Jul
21;336(8708):149-50. Review. PubMed PMID: 1973476.
166: Robak T. [Clinical pharmacology of pentostatin]. Pol Tyg Lek. 1990
May 21-28;45(21-22):435-8. Review. Polish. PubMed PMID: 2267194.
167: Black DJ, Livingston RB. Antineoplastic drugs in 1990. A review
(Part I). Drugs. 1990 Apr;39(4):489-501. Review. PubMed PMID: 2190792.
168: Doane LL, Ratain MJ, Golomb HM. Hairy cell leukemia. Current
management. Hematol Oncol Clin North Am. 1990 Apr;4(2):489-502. Review.
PubMed PMID: 2182604.
169: Riscoe MK, Brouns MC, Fitchen JH. Purine metabolism as a target for
leukemia chemotherapy. Blood Rev. 1989 Sep;3(3):162-73. Review. PubMed
PMID: 2676034.
170: Grek V, Hay F, Beguin Y, Andrien F, Dokekias A, Fillet G. [Hairy
cell leukemia: 30 years later]. Rev Med Liege. 1989 May
15;44(10):358-64. Review. French. PubMed PMID: 2664964.
171: Damasio EE, Pagnucco G, Federico M, Annino L, Chisesi T, Lamparelli
T, Lauria F, Castoldi G, Resegotti L. Hairy cell leukemia. A
therapeutical update. Haematologica. 1989 Mar-Apr;74(2):205-18. Review.
PubMed PMID: 2473014.
172: Rosa F, Casciaro S, Gatti AM, Boccaccio P, Ghio R. [Therapeutic
aspects of hairy cell leukemia]. Recenti Prog Med. 1989 Jan;80(1):37-44.
Review. Italian. PubMed PMID: 2469113.
173: O'Dwyer PJ, Cheson BD, Leyland-Jones B, King SA, Hoth DF.
Deoxycoformycin: an active new drug for indolent lymphomas and hairy
cell leukemia. Oncology (Williston Park). 1988 Jun;2(6):17-23, 26-7.
Review. PubMed PMID: 3079330.
174: Ho AD, Ganeshaguru K. Enzymes of purine metabolism in lymphoid
neoplasms, clinical relevance for treatment with enzyme inhibitors. Klin
Wochenschr. 1988 Jun 1;66(11):467-74. Review. PubMed PMID: 2841534.
175: Lazarus HM, Berger NA. Chemotherapy of malignant disease: an
update. Compr Ther. 1988 May;14(5):56-63. Review. PubMed PMID: 3292138.
176: O'Dwyer PJ, Wagner B, Leyland-Jones B, Wittes RE, Cheson BD, Hoth
DF. 2'-Deoxycoformycin (pentostatin) for lymphoid malignancies. Rational
development of an active new drug. Ann Intern Med. 1988
May;108(5):733-43. Review. PubMed PMID: 3282467.
177: Weiss GR, Arteaga CL, Brown TD, Craig JB, Harman GS, Havlin KA,
Koeller JM, Kuhn JG, Von Hoff DD. New anticancer agents. Cancer
Chemother Biol Response Modif. 1988;10:85-116. Review. PubMed PMID:
2484323.
178: Galton DA, Brito-Babapulle F. The management of myelomatosis. Eur J
Haematol. 1987 Nov;39(5):385-98. Review. PubMed PMID: 2446915.
179: Debusscher L, Stryckmans P. Perspectives in the treatment of hairy
cell leukemia. Eur J Cancer Clin Oncol. 1987 Aug;23(8):1095-7. Review.
PubMed PMID: 3308481.
180: Cheson BD, Martin A. Clinical trials in hairy cell leukemia.
Current status and future directions. Ann Intern Med. 1987
Jun;106(6):871-8. Review. Erratum in: Ann Intern Med 1987
Oct;107(4):604. PubMed PMID: 3555204.
181: Spiers AS. The role of pentostatin (2'-deoxycoformycin, dCF) in the
management of lymphoproliferative malignancies. Blood Rev. 1987
Jun;1(2):106-10. Review. PubMed PMID: 3332090.
182: Catovsky D, Quesada JR, Golomb HM. Guidelines for the treatment of
hairy cell leukemia. Leukemia. 1987 Apr;1(4):405-6. Review. PubMed PMID:
3312840.
183: Glaspy JA, Jacobs AD, Golde DW. Evolving therapy of hairy cell
leukemia. Cancer. 1987 Feb 1;59(3 Suppl):652-7. Review. PubMed PMID:
10822465.
184: Weiss GR, Arteaga CL, Brown TD, Craig JB, Harman GS, Koeller JM,
Kuhn JG, Von Hoff DD. New anticancer agents. Cancer Chemother Biol
Response Modif. 1987;9:93-120. Review. PubMed PMID: 2484330.
185: Lembersky BC, Golomb HM. Hairy cell leukemia: clinical features and
therapeutic advances. Cancer Metastasis Rev. 1987;6(3):283-300. Review.
PubMed PMID: 2446791.
186: Golde DW, Jacobs AD, Glaspy JA, Champlin RE. Hairy-cell leukemia:
biology and treatment. Semin Hematol. 1986 Jul;23(3 Suppl 1):3-9.
Review. PubMed PMID: 3526560.
187: Radulovacki M. Role of adenosine in sleep in rats. Rev Clin Basic
Pharm. 1985 Jul-Dec;5(3-4):327-39. Review. PubMed PMID: 3916307.
188: Doll DC, Weiss RB. Hemolytic anemia associated with antineoplastic
agents. Cancer Treat Rep. 1985 Jul-Aug;69(7-8):777-82. Review. PubMed
PMID: 3160460.
189: Seegmiller JE. Overview of possible relation of defects in purine
metabolism to immune deficiency. Ann N Y Acad Sci. 1985;451:9-19.
Review. PubMed PMID: 3935028.
190: Hirschhorn R, Ratech H. Genetic deficiencies of adenosine deaminase
and purine nucleoside phosphorylase and their implications for therapy
of leukemias. Curr Top Hematol. 1983;4:1-35. Review. PubMed PMID:
6413135.
191: Parkinson DR, Mier JW. T-lymphocyte malignancies: recent advances
in the understanding of their biology, diagnosis and treatment. Clin
Immunol Rev. 1983;2(1):59-121. Review. PubMed PMID: 6349892.
192: Agarwal RP. Inhibitors of adenosine deaminase. Pharmacol Ther.
1982;17(3):399-429. Review. PubMed PMID: 6187032.
193: Poster DS, Penta JS, Bruno S, Macdonald JS. 2'-deoxycoformycin. A
new anticancer agent. Cancer Clin Trials. 1981;4(2):209-13. Review.
PubMed PMID: 7018725.
194: Mitchell BS, Kelley WN. Purinogenic immunodeficiency diseases:
clinical features and molecular mechanisms. Ann Intern Med. 1980
Jun;92(6):826-31. Review. PubMed PMID: 6247948.
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