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 Nimustine

Nimustine is a nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). 

1: Watanabe S, Sato S, Nagase S, Ohkuma S. Chemotherapeutic choice of ranimustine or nimustine on the basis of regional polyamine levels in rat brain. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):115-20. PubMed PMID: 18560626.

2: Batista LF, Roos WP, Christmann M, Menck CF, Kaina B. Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. Cancer Res. 2007 Dec 15;67(24):11886-95. PubMed PMID: 18089819.

3: Seya T, Tanaka N, Shinji S, Shinji E, Yokoi K, Horiba K, Kanazawa Y, Yamada T, Oaki Y, Tajiri T. Case of rectal malignant melanoma showing immunohistochemical variability in a tumor. J Nippon Med Sch. 2007 Oct;74(5):377-81. PubMed PMID: 17965534.

4: Hoshida Y, Moriyama M, Otsuka M, Kato N, Taniguchi H, Shiratori Y, Seki N, Omata M. Gene expressions associated with chemosensitivity in human hepatoma cells. Hepatogastroenterology. 2007 Mar;54(74):489-92. PubMed PMID: 17523305.

5: Ono A, Kanno H, Hayashi A, Nishimura S, Kyuma Y, Sato H, Ito S, Shimizu N, Chang CC, Gondo G, Yamamoto I, Sasaki T, Tanaka M. Collagen gel matrix assay as an in vitro chemosensitivity test for malignant astrocytic tumors. Int J Clin Oncol. 2007 Apr;12(2):125-30. Epub 2007 Apr 27. PubMed PMID: 17443280.

6: Iwadate Y, Sakaida T, Saegusa T, Hiwasa T, Takiguchi M, Fujimoto S, Yamaura A. Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. Int J Oncol. 2005 Apr;26(4):993-8. PubMed PMID: 15753994.

7: Fleischhack G, Jaehde U, Bode U. Pharmacokinetics following intraventricular administration of chemotherapy in patients with neoplastic meningitis. Clin Pharmacokinet. 2005;44(1):1-31. Review. PubMed PMID: 15634030.

8: Koike M, Fujita F, Komori K, Katoh F, Sugimoto T, Sakamoto Y, Matsuda M, Fujita M. Dependence of chemotherapy response on p53 mutation status in a panel of human cancer lines maintained in nude mice. Cancer Sci. 2004 Jun;95(6):541-6. PubMed PMID: 15182437.

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10: Kono K, Ueba T, Takahashi JA, Murai N, Hashimoto N, Myoumoto A, Itoh N, Fukumoto M. In vitro growth suppression of human glioma cells by a 16-mer oligopeptide: a potential new treatment modality for malignant glioma. J Neurooncol. 2003 Jun;63(2):163-71. Erratum in: J Neurooncol. 2003 Sep;64(3):283. PubMed PMID: 12825820.

11: Moriyama M, Hoshida Y, Otsuka M, Nishimura S, Kato N, Goto T, Taniguchi H, Shiratori Y, Seki N, Omata M. Relevance network between chemosensitivity and transcriptome in human hepatoma cells. Mol Cancer Ther. 2003 Feb;2(2):199-205. PubMed PMID: 12589037.

12: Morikawa N, Mori T, Kawashima H, Takeyama M, Abe T, Kobayashi H. Pharmacokinetics of nimustine, cytosine arabinoside, and methotrexate in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy. Biol Pharm Bull. 2001 Apr;24(4):436-8. PubMed PMID: 11305611.

13: Ikeda J. [Roles of p53 in chemotherapy of glioblastoma]. Hokkaido Igaku Zasshi. 2000 Sep;75(5):299-314. Japanese. PubMed PMID: 11070791.

14: Morikawa N, Mori T, Abe T, Kawashima H, Takeyama M, Hori S. Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy. Biol Pharm Bull. 2000 Jun;23(6):784-7. PubMed PMID: 10864038.

15: Nio Y, Tamura K, Kan N, Inamoto T, Ohgaki K, Kodama H. Anticancer chemosensitivity profiles of human breast cancer cells assessed by in vitro DNA synthesis inhibition assay. Anticancer Res. 2000 Mar-Apr;20(2B):1237-44. PubMed PMID: 10810427.

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17: Horikoshi T, Naganuma H, Ohashi Y, Ueno T, Nukui H. Enhancing effect of electric stimulation on cytotoxicity of anticancer agents against rat and human glioma cells. Brain Res Bull. 2000 Mar 15;51(5):371-8. PubMed PMID: 10715556.

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20: Abe T, Mori T, Wakabayashi Y, Nakagawa M, Cole SP, Koike K, Kuwano M, Hori S. Expression of multidrug resistance protein gene in patients with glioma after chemotherapy. J Neurooncol. 1998 Oct;40(1):11-8. PubMed PMID: 9874181.

21: Morikawa N, Mori T, Kawashima H, Takeyama M, Hori S. Pharmacokinetics of anticancer drugs in cerebrospinal fluid. Ann Pharmacother. 1998 Oct;32(10):1008-12. PubMed PMID: 9793590.

22: Morikawa N, Mori T, Kawashima H, Fujiki M, Abe T, Kaku T, Konisi Y, Takeyama M, Hori S. Pharmacokinetics of nimustine, methotrexate, and cytosine arabinoside during cerebrospinal fluid perfusion chemotherapy in patients with disseminated brain tumors. Eur J Clin Pharmacol. 1998 Jul;54(5):415-20. PubMed PMID: 9754986.

23: Noda Y, Hayatsu H, Kawazoe Y. Effects of treatment with nimustine (ACNU), a bifunctional alkylating anticancer agent, on cultured resting L1210 cells. Biol Pharm Bull. 1998 Apr;21(4):414-7. PubMed PMID: 9586585.

24: Wang LH, Okaichi K, Ihara M, Okumura Y. Sensitivity of anticancer drugs in Saos-2 cells transfected with mutant p53 varied with mutation point. Anticancer Res. 1998 Jan-Feb;18(1A):321-5. PubMed PMID: 9568097.

25: Aoki H, Ohnishi K, Wang X, Takahashi A, Ohnishi T, Nakamura M, Sakaki T. p53-independent WAF1 induction by ACNU in human glioblastoma cells. Mol Carcinog. 1998 Mar;21(3):171-6. PubMed PMID: 9537648.

26: Mizushima Y, Li H, Sassa K, Fujishita T, Oosaki R, Kobayashi M. Grouping of anticancer drugs based on administration method-related toxicity patterns in rats. Anticancer Res. 1997 Nov-Dec;17(6D):4611-4. PubMed PMID: 9494577.

27: Hiwasa T, Tokita H, Sakiyama S, Nakagaware A. Enhancement of chemosensitivity toward anticancer drugs by high expression of caspase-1 in NIH 3T3 cells. Anticancer Drugs. 1998 Jan;9(1):82-7. PubMed PMID: 9491796.

28: Reber U, Wüllner U, Trepel M, Baumgart J, Seyfried J, Klockgether T, Dichgans J, Weller M. Potentiation of treosulfan toxicity by the glutathione-depleting agent buthionine sulfoximine in human malignant glioma cells: the role of bcl-2. Biochem Pharmacol. 1998 Feb 1;55(3):349-59. PubMed PMID: 9484802.

29: Suzuki M, Sugimoto Y, Tsukahara S, Okochi E, Gottesman MM, Tsuruo T. Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy. Clin Cancer Res. 1997 Jun;3(6):947-54. PubMed PMID: 9815770.

30: Fujii T. Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring. Cancer Causes Control. 1997 May;8(3):524-8. PubMed PMID: 9498910.

31: Iwadate Y, Fujimoto S, Sueyoshi K, Namba H, Tagawa M, Yamaura A. Prediction of drug cytotoxicity in 9L rat brain tumor by using flow cytometry with a deoxyribonucleic acid-binding dye. Neurosurgery. 1997 Apr;40(4):782-7; discussion 787-8. PubMed PMID: 9092852.

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33: Jeremic B, Shibamoto Y, Abe M. Assessment of micronucleus induction in murine SCCVII cells treated with various anticancer agents. Chemotherapy. 1996 Jul-Aug;42(4):266-72. PubMed PMID: 8804794.

34: Hiwasa T, Tokita H, Ike Y. Differential chemosensitivity in oncogene-transformed cells. J Exp Ther Oncol. 1996 May;1(3):162-70. PubMed PMID: 9414400.

35: Gao XS, Asaumi J, Kawasaki S, Nishikawa K, Kuroda M, Takeda Y, Hiraki Y, Ihara M, Ohnishi T. Sensitivity of anticancer drugs in NIH3T3' cells transfected with oncogenes accompanied by pSV2neo vector. Anticancer Res. 1995 Sep-Oct;15(5B):1911-4. PubMed PMID: 8572577.

36: Kabuto M, Kubota T, Kobayashi H, Nakagawa T, Arai Y, Kitai R. Experimental study of intraoperative local chemotherapy with fibrin glue containing nitrosourea for malignant gliomas. Surg Neurol. 1995 Aug;44(2):151-6; discussion 156-7. PubMed PMID: 7502205.

37: Yamanaka T, Hishinuma A. [Different effects of anticancer drugs on two human thyroid cell lines with different stages of differentiation]. Nippon Naibunpi Gakkai Zasshi. 1995 Jan 20;71(1):73-86. Japanese. PubMed PMID: 7895867.

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39: Numa Y, Kasai H, Imahori T, Tsuchida T, Kawamoto K. [Effective measures against side effects by increasing ACNU dose for malignant glioma: effects on digestive organs]. Gan To Kagaku Ryoho. 1994 Sep;21(12):2029-33. Japanese. PubMed PMID: 7522001.

40: Ikenaga M. [Cytotoxic action of alkylating agents in human tumor cells and its relationship to apoptosis]. Gan To Kagaku Ryoho. 1994 Apr;21(5):596-601. Review. Japanese. PubMed PMID: 8154884.

41: Kobayashi T, Tominaga T, Yoshimoto T. Cell death due to ACNU-induced DNA fragmentation: inhibition by cycloheximide. J Neurooncol. 1994;22(1):23-31. PubMed PMID: 7714548.

42: Kuroda R, Akai F, Iwasaki H, Nakatani J, Uchiyama T, Ioku M, Kaetsu I. Interstitial chemotherapy with biodegradable ACNU pellet for glioblastoma. Stereotact Funct Neurosurg. 1994;63(1-4):154-9. PubMed PMID: 7624627.

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44: Mizushima Y, Kashii T, Nakagawa K, Monno S, Yano S. Effects of granulocyte colony-stimulating factor, interleukin-1 alpha, and interleukin-6 on prolonged myelosuppression induced by nimustine hydrochloride in rats. J Immunother (1991). 1992 Aug;12(2):98-104. PubMed PMID: 1380297.

45: Otaki S, Kaneko H, Fukuma E, Yamakawa T. [Experimental study on the effect of injection with anticancer agent-oil suspension]. Gan To Kagaku Ryoho. 1992 Aug;19(10 Suppl):1587-9. Japanese. PubMed PMID: 1326923.

46: Yoshizumi Y, Sugiura Y, Morisaki Y, Shima S, Tanaka S. [Mitomycin-C-sensitive carcinoid tumor of the gallbladder: report of a case]. Gan To Kagaku Ryoho. 1992 Jun;19(6):893-6. Japanese. PubMed PMID: 1605667.

47: Nagane M, Asai A, Shibui S, Nomura K, Matsutani M, Kuchino Y. Expression of O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea resistance of human brain tumors. Jpn J Clin Oncol. 1992 Jun;22(3):143-9. PubMed PMID: 1518162.

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53: Nakamura O, Matsutani M, Nomura K, Takakura K. [Drug sensitivity test against malignant gliomas]. Gan To Kagaku Ryoho. 1990 Jun;17(6):1151-6. Japanese. PubMed PMID: 1693488.

54: Mizushima Y, Morikage T, Yano S. Differences in in vitro proliferative responsiveness to granulocyte colony-stimulating factor and interleukin 2 of bone marrow cells from mice treated with chemotherapeutic drugs. Cancer Res. 1990 Mar 15;50(6):1847-52. PubMed PMID: 1689612.

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58: Yamada K, Takahama H, Nakai O, Takanashi T, Hosoya T. [Intra-arterial chemotherapy of malignant glioma after osmotic blood-brain barrier disruption]. Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2692-6. Japanese. PubMed PMID: 2506817.

59: Ozawa S, Iwata K, Kubodera A, Inaba M. Intracellular glutathione levels in human colon cancer cells naturally resistant to cross-linking agents. J Pharmacobiodyn. 1989 Jul;12(7):378-83. PubMed PMID: 2593079.

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62: Miyagawa S, Kirby ML. Pathogenesis of persistent truncus arteriosus induced by nimustine hydrochloride in chick embryos. Teratology. 1989 Mar;39(3):287-94. PubMed PMID: 2727936.

63: Mizushima Y, Morikage T, Sasaki K, Yano S. [Experimental studies of anticancer drugs more appropriate for high-dose chemotherapy in bone marrow transplantation and their administration methods]. Gan To Kagaku Ryoho. 1989 Jan;16(1):59-66. Japanese. PubMed PMID: 2643394.

64: Miyagawa S, Ando M, Takao A. Cardiovascular anomalies produced by nimustine hydrochloride in the rat fetus. Teratology. 1988 Dec;38(6):553-8. PubMed PMID: 3238611.

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