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 Mitobronitol

Mitobronitol (1,6-dibromo-1,6-dideoxy-D-mannitol) is a brominated analog of mannitol. It is an anticancer drug that is classified as an alkylating agent. Pharmacological action: antineoplastic agent, alkylating.   

  1: Tanaka Y, Nagai Y, Mori M, Fujita H, Togami K, Kurata M, Matsushita A, Maeda A, Nagai K, Tanaka K, Takahashi T. Multiple granulocytic sarcomas in essential thrombocythemia. Int J Hematol. 2006 Dec;84(5):413-6. PubMed PMID: 17189221.

2: Barta A, Dénes R, Masszi T, Reményi P, Bátai A, Torbágyi E, Sipos A, Lengyel L, Jakab K, Gyódi E, Réti M, Földi J, Páldi-Haris P, Avalos M, Pálóczi K, Fekete S, Török J, Hoffer I, Jakab J, Váradi G, Kelemen E, Petrányi G. Remarkably reduced transplant-related complications by dibromomannitol non-myeloablative conditioning before allogeneic bone marrow transplantation in chronic myeloid leukemia. Acta Haematol. 2001;105(2):64-70. PubMed PMID: 11408706.

3: Windrum P, Hull DR, Morris TC. Herb-drug interactions. Lancet. 2000 Mar 18;355(9208):1019-20. PubMed PMID: 10768466.

4: Barta A, Bátai A, Kelemen E, Lengyel L, Reményi P, Sipos A, Torbágyi E, Avalos M, Fekete E, Földi J, Páldi-Haris P, Tamáska J, Gyódi E, Rajczy K, Hoffer I, Jakab J, Petrányi GG, Pálóczi K. Immunological importance of chimerism in transplantation: new conditioning protocol in BMT and the development of chimeric state. Hum Immunol. 2000 Feb;61(2):101-10. Review. PubMed PMID: 10717801.

5: Masszi T, Reményi P, Kriván G, Goda V, Réti M. Allogeneic bone marrow transplantation for acute leukemia in adults. Bone Marrow Transplant. 1998 Dec;22 Suppl 4:S77-9. PubMed PMID: 9916643.

6: Barta A, Batai A, Torbagyi E, Sipos A, Lengyel L, Petranyi GG, Paloczi K, Kelemen E. Haemopoietic cell transplantation activity and results: a single institution experience. Bone Marrow Transplant. 1998 Dec;22 Suppl 4:S60-2. PubMed PMID: 9916638.

7: Kelemen E, Dénes R, Barta A, Masszi T, Reményi P, Pálóczi K, Bátai A, Torbágyo E, Sipos A, Lengyel L, Jakab K, Gyódi E, Réti M, Földi J, Páldi-Haris P, Manuel A, Fekete S, Török J, Hoffer I, Jakab J, Váradi G, Petrányi G. [A new radiation-free conditioning in bone marrow transplantation and dibromo-mannitol therapy in chronic myeloid leukemia]. Orv Hetil. 1998 Aug 23;139(34):2003-1; discussion 2011-2. Review. Hungarian. PubMed PMID: 9745304.

8: Kelemen E, Masszi T, Reményi P, Barta A, Pálóczi K. Reduction in the frequency of transplant-related complications in patients with chronic myeloid leukemia undergoing BMT preconditioned with a new, non-myeloablative drug combination. Bone Marrow Transplant. 1998 Apr;21(8):747-9. PubMed PMID: 9603396.

9: Szebeni J, Barna K, Uher F, Milosevits J, Pálóczi K, Gaál D, Petrányi GG, Kelemen E. Comparison of the lymphoid toxicities of mitobronitol and busulphan in mice: reduced B cell toxicity and improved thymic recovery as possible contributors to the reduced risk for complications following BMT with mitobronitol preconditioning. Leukemia. 1997 Oct;11(10):1769-74. PubMed PMID: 9324299.

10: Tsuji T. Erythemas associated with essential thrombocythemia. J Dermatol. 1995 Oct;22(10):788-94. PubMed PMID: 8586763.

11: Milosevits J, Dénes R, Poros A, Reményi P, Bátai A, Barta A, Masszi T, Lengyel L, Jakab K, Földi J, et al. Lymphocyte subset reconstitution after allogeneic bone marrow transplantation using radiation-free conditioning regimen for patients with chronic granulocytic leukemia. Int J Hematol. 1995 Jul;62(1):27-33. PubMed PMID: 7670005.

12: Cserháti T. Charge-transfer chromatographic study of the complex formation of some anticancer drugs with gamma-cyclodextrin. Anal Biochem. 1995 Mar 1;225(2):328-32. PubMed PMID: 7762799.

13: Takeyama H, Shimokawa T, Yamada H, Watanabe E. [A clinical study of sixteen polycythemia vera cases--acute myeloblastic leukemia in patients with polycythemia vera]. Gan To Kagaku Ryoho. 1994 Dec;21(16):2833-7. Japanese. PubMed PMID: 7993124.

14: Watanabe E, Shimokawa T, Yamada H, Takeyama H, Natsume S, Satake T. [A case of essential thrombocythemia with clonal evolution in the terminal phase]. Gan To Kagaku Ryoho. 1994 Mar;21(4):539-42. Japanese. PubMed PMID: 8129397.

15: Kelemen E, Jakab K, Váradi G, Jánossa M, Földi J, Dénes R. Non-supralethal mitobronitol/cytarabine/cyclophosphamide conditioning without irradiation before bone marrow transplantation for accelerated chronic granulocytic leukemia: apparent absence of acute graft-versus-host disease. Leukemia. 1993 Jul;7(7):939-45. PubMed PMID: 8321045.

16: Kovács P, Hernádi F, Institóris L, Benkö I. Early regeneration of colony forming units in culture (CFUc) of murine bone marrow after moderate doses of dibromomannitol. Acta Physiol Hung. 1990;75 Suppl:183-4. PubMed PMID: 2115228.

17: Zhu XQ, Qian JW, Dai LY. [Effect of dibromomannitol in the treatment of chronic myelogenous leukemia: report of 22 cases]. Zhonghua Nei Ke Za Zhi. 1988 Mar;27(3):157-8, 197. Chinese. PubMed PMID: 3146485.

18: Burger T, Schmelczer M, Molnár L, Pajor L, Koszorus S. Course and transformation of polycythaemia vera in relation to therapy. Acta Med Hung. 1988;45(1):97-113. PubMed PMID: 3412864.

19: Silver RT, Mick R, Cooper R, Ellison RR, Levy R, Brunner K, Schwartz JM, Holland JF. A comparative study of dibromomannitol and busulfan in the treatment of chronic myeloid leukemia. A study of cancer and leukemia group B. Cancer. 1987 Oct 1;60(7):1442-8. PubMed PMID: 3113712.

20: Kelemen E, Tura S, Burger T. Decreasing risk of leukaemia during prolonged follow-up after mitobronitol therapy for polycythaemia vera. Lancet. 1987 Sep 12;2(8559):625. PubMed PMID: 2887907.

21: Pozzato G, Terpin MM, Rinaldi C, Frezza M. [Clinical case. Primary thrombocythemia]. G Clin Med. 1987 Feb;68(2):121-3. Italian. PubMed PMID: 3609602.

22: Kamei T, Iwasa S, Okuda K, Izeki T, Kanazawa S, Kondo H, Okuda K, Yonemitsu H. [Polycythemia vera associated with marked pancytopenia in transition from the polycythemic stage to leukemia--a case report]. Rinsho Ketsueki. 1987 Feb;28(2):239-43. Japanese. PubMed PMID: 3573341.

23: Kovaleva LG, Kho PI. [Effectiveness of cytostatic therapy of polycythemia vera]. Gematol Transfuziol. 1986 Jul;31(7):42-6. Russian. PubMed PMID: 3744014.

24: Sokal JE, Baccarani M, Tura S, Fiacchini M, Cervantes F, Rozman C, Gomez GA, Galton DA, Canellos GP, Braun TJ, et al. Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation. Blood. 1985 Dec;66(6):1352-7. PubMed PMID: 3904870.

25: Kelemen E, Tura S. Mitobronitol: an alkylating agent that does not induce extra leukemia cases if applied as pulse therapy for polycythemia vera. Ann N Y Acad Sci. 1985;459:335. PubMed PMID: 3938195.

26: Gulya E, Kelemen E, Holló I. Inhibition of late splenic extra-colony formation by mitobronitol. Ann N Y Acad Sci. 1985;459:334. PubMed PMID: 3938194.

27: Kelemen E, Jánossa M, Triska E, Szalay F, Váradi A, Magyar T, Sellyei M. Bone marrow transplantation in accelerated chronic granulocytic leukaemia using dibromomannitol-preconditioning instead of total-body irradiation. Leuk Res. 1985;9(8):1009-15. PubMed PMID: 3930887.

28: Nevskaia TP. [15 years experience in treating chronic myeloleukemia patients at a polyclinic]. Gematol Transfuziol. 1984 Nov;29(11):12-5. Russian. PubMed PMID: 6597780.

29: Garciá-Conde J, Alberola V, Lluch A, Escrig V. [Conventional and aggressive chemo-radiotherapy of chronic granulocytic leukemia in its different phases. Other therapeutic problems]. Sangre (Barc). 1984;29(4-B):577-97. Review. Spanish. PubMed PMID: 6393383.

30: Davey P, Tudhope GR. Anticancer chemotherapy. Br Med J (Clin Res Ed). 1983 Jul 9;287(6385):110-3. PubMed PMID: 6407699; PubMed Central PMCID: PMC1548379.

31: Jaworkowsky L, Blumenthal R, Udris O, Sihle M, Terebkowa S. [Results and perspectives of therapy of chronic myelosis]. Z Gesamte Inn Med. 1983 Jun 1;38(11):307-9. German. PubMed PMID: 6351448.

32: Kelemen E. [Short-term massive myelobromol therapy in polycythemia vera: a 12-years' experience. Model for a clinical trial of cytostatic drugs]. Orv Hetil. 1983 Jan 2;124(1):3-13. Hungarian. PubMed PMID: 6402751.

33: Horváth IP, Somfai-Relle S, Hegedüs L, Jarman M. Toxicity, antitumour and haematological effects of 1,2-anhydro-6-bromogalactitol and d-mannitol: a comparison with the related dibromo- and dianhydro-derivatives. Eur J Cancer Clin Oncol. 1982 Jun;18(6):573-7. PubMed PMID: 6811281.

34: Kerpel-Fronius S. Hungarian anticancer drugs (antineoplastics). Ther Hung. 1982;30(3):110-21. Review. PubMed PMID: 6095482.

35: Griffin JD, Garnick MB. Eye toxicity of cancer chemotherapy: a review of the literature. Cancer. 1981 Oct 1;48(7):1539-49. Review. PubMed PMID: 7026021.

36: Chiuten DF, Rozencweig M, Von Hoff DD, Muggia FM. Clinical trials with the hexitol derivatives in the U.S. Cancer. 1981 Feb 1;47(3):442-51. Review. PubMed PMID: 6784907.

37: Herrmann R. [Recent developments in the treatment of chronic myeloid leukemia]. Med Klin. 1980 Aug 29;75(18):645-9. Review. German. PubMed PMID: 6106883.

38: Yonemitsu H, Kanazawa S, Kondo H, Yamaguchi K, Okuda K, Shigeta H. [Treatment of polycythemia vera with dibromomannitol (author's transl)]. Rinsho Ketsueki. 1980 May;21(5):587-91. Japanese. PubMed PMID: 6774132.

39: Fleischer J. [Splenectomy and polychemotherapy in chronic myelosis]. Z Gesamte Inn Med. 1979 Jun 15;34(12):148-9. German. PubMed PMID: 292262.

40: Vadnay I, Bereczky J, Szalóky P, Haraszti A. [Venous occlusive disease]. Orv Hetil. 1979 Mar 18;120(11):655-6. Hungarian. PubMed PMID: 431928.

41: Kitajima K. [Problems on the treatment of chronic myelogenous leukemia (CML)--from the point of the blast crisis (author's transl)]. Rinsho Ketsueki. 1978 Apr;19(4):386-91. Japanese. PubMed PMID: 279725.

42: Osechenskaia GV, Krasiukova LI. [Current aspects of the treatment of polycythemia vera under polyclinical conditions]. Probl Gematol Pereliv Krovi. 1978 Jan;23(1):21-4. Russian. PubMed PMID: 628661.

43: Misawa S, Sawai K, Ide T, Sonoda Y, Takemura S. [Incidence of the Philadelphia chromosome before and after DCMP-therapy during the chronic phase of chronic myelocytic leukemia (author's transl)]. Rinsho Ketsueki. 1977 Sep 30;18(9):1121-7. Japanese. PubMed PMID: 271250.

44: Klimova NF. [10-years experience with myelobromol treatment of myelofibrosis]. Haematologia (Budap). 1977;11(1-2):57-72. Russian. PubMed PMID: 615089.

45: Demidova AV, Sysoeva NA. [Tactics of cytostatic therapy of primary and secondary (post-erythremic) myelofibrosis]. Probl Gematol Pereliv Krovi. 1976 Jul;21(7):23-7. Russian. PubMed PMID: 1071792.

46: Tomov C, Avramova D, Ghenova V, Gigova D, Georgiev Z. Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol). Ther Hung. 1976;24(2):56-9. PubMed PMID: 1068542.

47: Eckhardt S. Clinical pharmacology of carbohydrate derivatives with cytostatic potency. Adv Enzyme Regul. 1976;14:297-311. Review. PubMed PMID: 788476.

48: Schwartz JH, Cannellos GP. Hydroxyurea in the management of the hematologic complications of chronic granulocytic leukemia. Blood. 1975 Jul;46(1):11-6. PubMed PMID: 1055610.

49: Kitajima K. [Leukemia planning of chemotherapy]. Nippon Rinsho. 1975 May 10;33(5):1840-6. Japanese. PubMed PMID: 125354.

50: Fuzy M, Lelieveld P, Van Putten LM. The effect of cytostatic hexitol derivatives on haematopoietic stem cells, the L1210 leukaemia and C22LR osteosarcoma. Eur J Cancer. 1975 Mar;11(3):169-73. PubMed PMID: 165939.

51: Nagy G, Léhi M. Cytostatic treatment of polycythaemia rubra vera. Comparison of the effects of some cytostatics in 100 patients in a period of five years. Haematologia (Budap). 1975;9(3-4):283-6. PubMed PMID: 181298.

52: Weisburger JH, Griswold DP, Prejean JD, Casey AE, Wood HB, Weisburger EK. The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy. Recent Results Cancer Res. 1975;(52):1-17. PubMed PMID: 138176.