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MedKoo product information:
Methylisoindigotin
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MedKoo Code#: 100622
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Name:
Methylisoindigotin
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CAS#: 97207-47-1
Synonym: Methyl isoindigotin.
IUPAC/Chemical name:
(E)-1,1'-dimethyl-[3,3'-biindolinylidene]-2,2'-dione
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Chemical structure:
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Theoretical analysis
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Chemical Formula: C18H14N2O2
Exact Mass: 290.10553
Molecular Weight: 290.31
m/z: 290.10553 (100.0%), 291.10888 (19.5%),
292.11224 (1.8%)
Elemental Analysis: C, 74.47; H, 4.86; N,
9.65; O, 11.02
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Availability and price:
For quotation, question, and order, please send email to
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for larger quantity order.
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Quality control
data:
Product will be shipped with
supporting analytical data.
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Information about this agent
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Methyl isoindigotin was
approved for treating cancers in China.
Methyl isoindigotin is an
orally bioavailable anticancer drug, which belongs to
anti-metabolite drugs.
1: Huang M, Lee YS, Ho PC. Identification of
circulatory and excretory metabolites of meisoindigo in rat plasma,
urine and feces by high-performance liquid chromatography coupled with
positive electrospray ionization tandem mass spectrometry. Rapid Commun
Mass Spectrom. 2010 Mar;24(6):729-41. PubMed PMID: 20169560.
2: Chen F, Li L, Ma D, Yan S, Sun J, Zhang M, Ji C, Hou M. Imatinib
achieved complete cytogenetic response in a CML patient received 32-year
indirubin and its derivative treatment. Leuk Res. 2010 Feb;34(2):e75-7.
Epub 2009 Sep 20. PubMed PMID: 19773083.
3: Huang M, Ho PC. Identification of metabolites of meisoindigo in rat,
pig and human liver microsomes by UFLC-MS/MS. Biochem Pharmacol. 2009
Apr 15;77(8):1418-28. Epub 2009 Jan 29. PubMed PMID: 19426681.
4: Liu BC, Xiao ZJ. [Effect on bcr-abl signaling pathway and the
mechanisms of apoptosis induction by meisoindigo in K562 cells].
Zhonghua Xue Ye Xue Za Zhi. 2008 Dec;29(12):815-8. Chinese. PubMed PMID:
19176035.
5: Mingxin Z, Yan L, Hongbo W, Jianhua Z, Hongyan L, He L, Hongqi X, Sen
Z, Xiaoguang C. The antitumor activity of meisoindigo against human
colorectal cancer HT-29 cells in vitro and in vivo. J Chemother. 2008
Dec;20(6):728-33. PubMed PMID: 19129071.
6: Huang M, Choo LW, Ho PC. Characterization of metabolites of
meisoindigo in male and female rat kidney microsomes by high-performance
liquid chromatography coupled with positive electrospray ionization
tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008
Dec;22(23):3835-45. PubMed PMID: 18980268.
7: Huang M, Goh LT, Ho PC. Identification of stereoisomeric metabolites
of meisoindigo in rat liver microsomes by achiral and chiral liquid
chromatography/tandem mass spectrometry. Drug Metab Dispos. 2008
Nov;36(11):2171-84. Epub 2008 Aug 18. PubMed PMID: 18710897.
8: Wang Y, Zhu XF, Xiao ZJ, Wang HH, Zhou JM, Mei YP, Deng R, Jiang WQ,
Liu ZC. [Inducement effect of Meisoindigo on apoptosis of leukemia cell
line HL-60 and its mechanism]. Ai Zheng. 2005 Dec;24(12):1464-8.
Chinese. PubMed PMID: 16351793.
9: Xiao Z, Wang Y, Lu L, Li Z, Peng Z, Han Z, Hao Y. Anti-angiogenesis
effects of meisoindigo on chronic myelogenous leukemia in vitro. Leuk
Res. 2006 Jan;30(1):54-9. Epub 2005 Jun 27. PubMed PMID: 15982734.
10: Meng Z, Li WY, Hou LY, Xue HM, Xia Y, Guo HX, Deng QL. [Effects of
meisoindigo on the expression of globin gene in vitro]. Zhonghua Er Ke
Za Zhi. 2004 Mar;42(3):184-7. Chinese. PubMed PMID: 15144711.
11: Xiao Z, Hao Y, Liu B, Qian L. Indirubin and meisoindigo in the
treatment of chronic myelogenous leukemia in China. Leuk Lymphoma. 2002
Sep;43(9):1763-8. Review. PubMed PMID: 12685829.
12: Song L, Qian L. [Apoptosis inducing effect of meisoindigo on K562
cells]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Jun;19(6):353-5.
Chinese. PubMed PMID: 11783201.
13: Xiao Z, Qian L, Liu B, Hao Y. Meisoindigo for the treatment of
chronic myelogenous leukaemia. Br J Haematol. 2000 Nov;111(2):711-2.
PubMed PMID: 11122126.
14: Liu XM, Wang LG, Li HY, Ji XJ. Induction of differentiation and
down-regulation of c-myb gene expression in ML-1 human myeloblastic
leukemia cells by the clinically effective anti-leukemia agent
meisoindigo. Biochem Pharmacol. 1996 Jun 14;51(11):1545-51. PubMed PMID:
8630096.
15: Ji XJ, Liu XM, Li K, Chen RH, Wang LG. Pharmacological studies of
meisoindigo: absorption and mechanism of action. Biomed Environ Sci.
1991 Sep;4(3):332-7. PubMed PMID: 1764225.
16: Peng Y, Wang MZ. [Screening for in vitro metabolites of meisoindigo
using RP-HPLC-DAD with gradient elution]. Yao Xue Xue Bao.
1990;25(3):208-14. Chinese. PubMed PMID: 2239336.
17: Ji XJ, Zhang FR, Liu Y, Gu QM. [Studies on the antineoplastic action
of N-methylisoindigotin]. Yao Xue Xue Bao. 1985 Apr;20(4):247-51.
Chinese. PubMed PMID: 4072694.
18: Liu JZ, Wu GY, Gao BH. [Studies on the mechanism of antitumor action
of Dian III]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1984 Dec;6(6):402-4.
Chinese. PubMed PMID: 6242539.
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